A5072723216- Cancer survivorship and care
- Health Systems, Economic Evaluations, Quality of Life
- Clinical practice guidelines implementation
- Palliative Care and End-of-Life Issues
- Breast Cancer Treatment Studies
- Patient-Provider Communication in Healthcare
- Health and Medical Studies
- Head and Neck Cancer Studies
- Insurance and Financial Risk Management
- Colorectal Cancer Surgical Treatments
- Cancer Treatment and Pharmacology
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Lung Cancer Treatments and Mutations
- Hearing, Cochlea, Tinnitus, Genetics
- Childhood Cancer Survivors' Quality of Life
- Global Cancer Incidence and Screening
- Cutaneous Melanoma Detection and Management
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Medical Practices and Rehabilitation
- Frailty in Older Adults
- Skin Protection and Aging
- Nonmelanoma Skin Cancer Studies
University Hospital Regensburg
2016-2025
Medical University of Graz
2023-2025
University of Regensburg
2012-2024
Kinderklinik Regensburg
2024
Klinik und Poliklinik für Kinder- und Jugendmedizin
2024
Regensburg University of Applied Sciences
2024
TU Wien
2019-2023
Hôpital Beau-Séjour
2023
Financial Research (Hungary)
2023
Center for Clinical Studies
2009-2023
Clinical decision-making often relies on a subject's absolute risk of disease event interest. However, in frail population, competing events may preclude the occurrence We review competing-risk regression models with view toward predictive modeling. show how measures prognostic performance (such as calibration and discrimination) can be adapted to competing-risks setting. An example coronary heart (CHD) prediction women aged 55-90 years Rotterdam study is used illustrate proposed methods,...
The proliferation marker Ki-67 is one of the most controversially discussed parameters for treatment decisions in breast cancer patients. purpose this study was to evaluate routine use and value as a prognostic marker, analyze associations between common histopathological clinical setting. Data from registry Regensburg (Bavaria, Germany) were analyzed. Within total data pool 4,692 female patients, who had been diagnosed 2005 2011, 3,658 cases routinely determined. Thus, patients with...
Life expectancy has dramatically increased in industrialized nations over the last 200 hundred years. The aging of populations carries to clinical research and leads an increasing representation elderly multimorbid individuals study populations. Clinical these is complicated by fact that are likely experience several potential disease endpoints prevent some disease‐specific endpoint interest from occurrence. Large developments competing risks methodology have been achieved decades, but we...
Studies in cardiology often record the time to multiple disease events such as death, myocardial infarction, or hospitalization. Competing risks methods allow for analysis of first observed event and type event. They are also relevant if a specific is primary interest but competing may preclude its occurrence greatly alter chances observe it. We give non-technical overview concepts descriptive regression analyses. For statistics, cumulative incidence function most important tool. modelling,...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic challenges national health systems and the global economy. Monitoring of infection rates seroprevalence can guide public measures to combat pandemic. This depends on reliable tests active former infections. Here, we set out develop validate a specific sensitive enzyme linked immunosorbent assay (ELISA) for detection anti-SARS-CoV-2 antibody levels.In our ELISA, used SARS-CoV-2 receptor-binding domain (RBD) stabilized...
After infection of B cells, Epstein-Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity drive immune dysregulation lymphomagenesis. We found EBV protein EBNA2 initiates nicotinamide adenine dinucleotide (NAD) de novo biosynthesis by driving expression metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) in infected cells. Virus-enforced NAD production sustained mitochondrial complex I activity, match adenosine...
The number of operations to reach a plateau phase in colorectal laparoscopic surgery is still under debate. There are few publications reporting on multidimensional assessment the learning curve, including operation time and complication conversion rates. purpose this study was define curve for sigmoid resection performed by two surgeons with experience surgery.Between 1993 2001 from total 715 procedures, self-educated 338 resections. Demographic data, indications surgery, procedure...
Objective To determine the minimum change of Tinnitus Handicap Inventory (THI) score that could be considered clinically relevant, authors compared absolute THI with Clinical Global Impression–Improvement (CGI‐I) score. Study Design International studies register standardized data collection. Setting Research Initiative (TRI). Subjects and Methods Two hundred ten patients TRI database were eligible for this study. In first analysis, CGI‐I ratings equipercentile linking. a second categorized...
Radiopeptide therapy is commonly performed with a single radioisotope. We aimed to compare the effectiveness of somatostatin-based radiopeptide versus combination radioisotopes.In cohort study, patients metastasized neuroendocrine cancer were treated repeated cycles (90)yttrium-labeled tetraazacyclododecane-tetraacetic acid modified Tyr-octreotide ([(90)Y-DOTA]-TOC) or alternating between [(90)Y-DOTA]-TOC and (177)lutetium-labeled DOTA-TOC ([(177)Lu-DOTA]-TOC) until tumor progression...
Patient management in emergency departments (EDs) is often based on protocols developed for specific complaints like dyspnea, chest pain, or syncope. To the best of our knowledge, to date no exist patients with nonspecific (NSCs) such as "weakness,""dizziness," "feeling unwell." The objectives this study were provide a framework research and description NSCs presenting EDs.Nonspecific defined entity not part set which evidence-based physicians (EPs) exist. "Serious conditions" potentially...
Tissue engineering is a promising approach for the treatment of tissue defects. Mesenchymal stem cells are potential use as source repair or important growth factors engineering. The purpose this study was to examine role mesenchymal in meniscal repair. This tested using several cell and biomaterial-based options defects avascular zone rabbit menisci. Circular punch (2 mm) were created menisci left empty filled with hyaluronan-collagen composite matrices without cells, loaded platelet-rich...
The concordance probability is a widely used measure to assess discrimination of prognostic models with binary and survival endpoints. We formally define the for model absolute risk an event interest in presence competing risks relate it recently proposed time-dependent area under receiver operating characteristic curve measures. For right-censored data, we investigate inverse censoring weighted (IPCW) estimates truncated index based on working distribution. demonstrate consistency...
Optimal control of Battery Energy Storage Systems (BESSs) is challenging because it needs to consider benefits arising in power system operation as well cost induced from BESS commitment. The presented approach relies on the methodology Model Predictive Control (MPC) for optimal operation. Variable and strongly usage dependent battery degradation costs constitute bulk marginal usually modeled with nonlinear functional dependencies or an implicit cycle counting unsuited MPC implementation. In...
Tinnitus, the phantom perception of sound, is a frequent disorder that causes significant morbidity and treatment elusive. A large variety different options have been proposed from most them some patients benefit. However, particular helps one patient may fail for others. This suggests there are forms tinnitus which differ in their pathophysiology response to specific treatments. Therefore, it major challenge identify promising therapy patient. published clinical studies enrolled only...