A5020699194- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Transcranial Magnetic Stimulation Studies
- Multisensory perception and integration
- Ear Surgery and Otitis Media
- Cerebral Venous Sinus Thrombosis
- Medical Practices and Rehabilitation
- RNA regulation and disease
- Neuroscience of respiration and sleep
- Olfactory and Sensory Function Studies
- Head and Neck Surgical Oncology
- Facial Nerve Paralysis Treatment and Research
- Ion channel regulation and function
- Heat shock proteins research
- Neural dynamics and brain function
- Biochemical Analysis and Sensing Techniques
- Sinusitis and nasal conditions
- Biomedical and Chemical Research
- Psychosomatic Disorders and Their Treatments
- Noise Effects and Management
- EEG and Brain-Computer Interfaces
- Biotin and Related Studies
- Sympathectomy and Hyperhidrosis Treatments
- Tactile and Sensory Interactions
University of Zurich
2016-2025
University Hospital of Zurich
2016-2025
Medical University of Vienna
2014-2023
ETH Zurich
2022
University of Regensburg
2007-2021
Klein Buendel (United States)
2013
University of Neuchâtel
2011
New York Proton Center
2011
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2004-2010
University Hospital Regensburg
2002-2010
Activation-dependent brain plasticity in humans on a structural level has been demonstrated adults after 3 months of training visio-motor skill. The exact timescale usage-dependent changes, whether days, months, or years, is, however, still debated. A better understanding the temporal parameters may help elucidate to what extent this type cortical contributes fast adapting processes that be relevant learning and effects treatments. Using voxel-based morphometry, we are able show repetitive...
OBJECTIVES: The pathophysiologic mechanisms of idiopathic tinnitus remain unclear. Recent studies demonstrated focal brain activation in the auditory cortex patients with chronic tinnitus. Low‐frequency repetitive transcranial magnetic stimulation (rTMS) is able to reduce cortical hyperexcitability. STUDY DESIGN: Fusing individual PET‐scan structural MRI‐scan (T1, MPRAGE) allowed us identify exactly area increased metabolic activity With use a neuronavigational system, this target was...
Objective To determine the minimum change of Tinnitus Handicap Inventory (THI) score that could be considered clinically relevant, authors compared absolute THI with Clinical Global Impression–Improvement (CGI‐I) score. Study Design International studies register standardized data collection. Setting Research Initiative (TRI). Subjects and Methods Two hundred ten patients TRI database were eligible for this study. In first analysis, CGI‐I ratings equipercentile linking. a second categorized...
Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the temporal cortex has been proposed as a new treatment strategy for patients with chronic tinnitus. However, functional abnormalities in tinnitus also involve brain structures used attentional and emotional processing, such dorsolateral prefrontal cortex. Therefore, we have developed rTMS that consists combination high-frequency low-frequency rTMS.A total 32 received either or rTMS. Treatment effects were assessed...
Abstract Cerebral 18 F‐deoxyglucose positron emission tomography (FDG‐PET) has shown altered auditory pathway activity in tinnitus. However, the corresponding studies involved only small samples and analyses were restricted to cortex most studies. Evidence is growing that also limbic, frontal, parietal areas are pathophysiology of chronic These regions considered mediate perceptual, attentional, emotional processes. Thus, aim present study was systematic evaluation metabolic brain a large...
Background Different mechanisms have been proposed to be involved in tinnitus generation, among them reduced lateral inhibition and homeostatic plasticity. On a perceptual level these different should reflected by the relationship between individual audiometric slope perceived pitch. Whereas some studies found pitch corresponding maximum hearing loss, others stressed relevance of edge frequency. This study investigates large sample. Methodology retrospective observational analyzed 286...
Evidence-based medicine (EBM) is generally accepted as the gold standard for high-quality and, thus, managing patients with tinnitus. EBM integrates best available scientific information clinical experience and patient values to guide decision-making about management. To help health care providers clinicians, evidence commonly translated into medical or guidelines based on a consensus. These involve systematic review of literature meta-analytic aggregation research findings followed by...
Abstract Tinnitus, the perception of sound without a corresponding external source, and tinnitus disorder, which is with associated suffering, present multifaceted clinical challenge due to its heterogeneity incompletely understood pathophysiology especially limited therapeutic options. In this narrative review, we give an overview on various aspects including heterogeneity, contributing factors, comorbidities pathways specific emphasis implications for future research directions. Tinnitus...
Unilaterally increased metabolic activity within the primary auditory cortex (PAC) represents a robust finding in tinnitus patients. Targeting these hyperactive areas with image-guided low frequency repetitive transcranial magnetic stimulation (rTMS) results subjective reduction. More pronounced activation of PAC predicted higher resistance to rTMS.[18F]deoxyglucose (FDG)-positron emission tomography (PET) was used assess central system tinnitus. The study investigated whether patterns...
Objectives Chronic tinnitus is associated with hyperactivity of the central auditory system. Low‐frequency repetitive transcra‐nial magnetic stimulation (rTMS) temporal cortex has been proposed as a treatment for chronic tinnitus. This study determined factors that predict beneficial outcome rTMS treatment. Study Design Forty‐five patients underwent 10 sessions low‐frequency to their left cortex. The was assessed questionnaire. Therapeutic success related patients' clinical characteristics....
Objectives. Tinnitus is related to alterations in neuronal activity of auditory and nonauditory brain areas. Targeted modulation these areas by repetitive transcranial magnetic stimulation (rTMS) has been proposed as a new therapeutic approach for chronic tinnitus. Methods. Two randomized, double-blind, parallel-group, controlled clinical trials were performed subsequently pooled analysis. A total 192 tinnitus patients randomly allocated receive 10 sessions either sham rTMS, PET-based...