A5062437739- Emergency and Acute Care Studies
- Sepsis Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumonia and Respiratory Infections
- Heart Failure Treatment and Management
- Electrolyte and hormonal disorders
- Respiratory Support and Mechanisms
- Acute Myocardial Infarction Research
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Hip and Femur Fractures
- SARS-CoV-2 and COVID-19 Research
- Clinical Reasoning and Diagnostic Skills
- Healthcare Policy and Management
- Intensive Care Unit Cognitive Disorders
- Venous Thromboembolism Diagnosis and Management
- Nosocomial Infections in ICU
- Healthcare cost, quality, practices
- Ultrasound in Clinical Applications
- Frailty in Older Adults
- COVID-19 and healthcare impacts
- Asthma and respiratory diseases
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
University Hospital of Basel
2016-2025
University of Basel
2015-2024
Hospital Base
2010-2024
OLVG
2018
Kantonsspital Aarau
2010-2015
Kantonsschule Olten
2015
Hospital Clínic de Barcelona
2015
Hospital Del Mar
2015
Luzerner Kantonsspital
2014
Spitalzentrum Centre hospitalier Biel- Bienne
2014
We conducted a multicenter study to examine the diagnostic accuracy of new, sensitive cardiac troponin assays performed on blood samples obtained in emergency department from 718 consecutive patients who presented with symptoms suggestive acute myocardial infarction. Cardiac levels were determined blinded fashion use four (Abbott–Architect Troponin I, Roche High-Sensitive T, and Siemens I Ultra) standard assay (Roche T). The final diagnosis was adjudicated by two independent cardiologists.
Rationale: In patients with community-acquired pneumonia, guidelines recommend antibiotic treatment for 7 to 21 d. Procalcitonin is elevated in bacterial infections, and its dynamics have prognostic implications.Objective: To assess procalcitonin guidance the initiation duration of therapy pneumonia.Methods: a randomized intervention trial, 302 consecutive suspected pneumonia were included. Data assessed at baseline, after 4, 6, 8 d, 6 wk.The control group (n = 151) received antibiotics...
Nitric oxide (NO) has been invoked as an important pathogenic factor in a wide range of immunologically mediated diseases. The present study demonstrates that macrophage-derived NO may conversely function to fine tune T cell-mediated inflammation via reversible dephosphorylation intracellular signaling molecules, which are involved the control cell proliferation. Thus, cells activated presence alveolar macrophages unable proliferate despite expression IL-2R and secretion IL-2. This process...
The purpose of this study was to examine the incremental value copeptin for rapid rule out acute myocardial infarction (AMI). and reliable exclusion AMI is a major unmet clinical need. Copeptin, C-terminal part vasopressin prohormone, as marker endogenous stress may be useful in setting. In 487 consecutive patients presenting emergency department with symptoms suggestive AMI, we measured levels at presentation, using novel sandwich immunoluminometric assay blinded fashion. final diagnosis...
Abstract Background Community-acquired pneumonia (CAP) is the most frequent infection-related cause of death. The reference standard to diagnose CAP a new infiltrate on chest radiograph in presence recently acquired respiratory signs and symptoms. This study aims evaluate diagnostic prognostic accuracy clinical symptoms laboratory biomarkers for CAP. Methods 545 patients with suspected lower tract infection, admitted emergency department university hospital were included pre-planned post-hoc...
<h3>Importance</h3>International guidelines advocate a 7- to 14-day course of systemic glucocorticoid therapy in acute exacerbations chronic obstructive pulmonary disease (COPD). However, the optimal dose and duration are unknown.<h3>Objective</h3>To investigate whether short-term (5 days) treatment patients with COPD exacerbation is noninferior conventional (14 clinical outcome it decreases exposure steroids.<h3>Design, Setting, Patients</h3>REDUCE (Reduction Use Corticosteroids Exacerbated...
<h3>Background:</h3> We aimed to prospectively validate a novel 1-hour algorithm using high-sensitivity cardiac troponin T measurement for early rule-out and rule-in of acute myocardial infarction (MI). <h3>Methods:</h3> In multicentre study, we enrolled 1320 patients presenting the emergency department with suspected MI. The algorithm, incorporating baseline values as well absolute changes within first hour, was validated against final diagnosis. diagnosis then adjudicated by 2 independent...
Rationale: High cortisol levels are of prognostic value in sepsis. The predictive pneumonia is unknown. Routinely available assays measure serum total (TC) and not free (FC). Whether FC concentrations better reflect outcome uncertain.Objectives: To investigate the TC community-acquired (CAP).Methods: Preplanned subanalysis a prospective intervention study 278 patients presenting to emergency department with CAP.Measurements Main Results: TC, FC, procalcitonin, C-reactive protein, leukocytes,...
Early prediction of outcome in patients with ischemic stroke is important. Vasopressin a stress hormone. Its production rate mirrored circulating levels copeptin, fragment provasopressin. We evaluated the prognostic value copeptin acute patients.In prospective observational study, was measured using new sandwich immunoassay on admission plasma 362 consecutive an stroke. The to predict functional (defined as modified Rankin Scale score <or=2 or >or=3), mortality within 90 days, compared...
Abstract Introduction Pro-adrenomedullin (proADM) is helpful for individual risk assessment and outcome prediction in sepsis. A major cause of sepsis community-acquired pneumonia (CAP). The aim this study was to investigate the value proADM levels severity CAP. Methods Data from 302 patients admitted emergency department with CAP were included a prospective observational study. Procalcitonin, C-reactive protein levels, leukocyte count, clinical variables index (PSI) measured. ProADM measured...
Abstract Background Vasopressin has haemodynamic as well osmoregulatory effects, and reflects the individual stress response. Copeptin is cosynthesized with vasopressin, directly mirroring vasopressin levels, but more stable in plasma serum. Both levels are increased patients septic shock. Lower respiratory tract infections (LRTI) a precursor of sepsis. Thus, we investigated circulating prognostic use copeptin for severity outcome LRTI. Materials methods Five hundred forty‐five consecutive...
Patient management in emergency departments (EDs) is often based on protocols developed for specific complaints like dyspnea, chest pain, or syncope. To the best of our knowledge, to date no exist patients with nonspecific (NSCs) such as "weakness,""dizziness," "feeling unwell." The objectives this study were provide a framework research and description NSCs presenting EDs.Nonspecific defined entity not part set which evidence-based physicians (EPs) exist. "Serious conditions" potentially...
The World Health Organization (WHO) declared the COVID-19 outbreak a “Public Emergency of International Concern” on 30 January 2020, after rapid spread from few initial cases to thousands across China and introductions into several other countries. On 11 March WHO classified as pandemic. first in Switzerland, Basel-Stadt, Basel-Landschaft were confirmed 25 February, 27 February 28 2020. As 22 April there are 28,154 including 933 811 Cantons Basel-Stadt Basel-Landschaft, respectively....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China as the cause of disease 2019 December and reached Europe by late January 2020, when community-acquired viruses (CARVs) are at their annual peak. We validated World Health Organization (WHO)-recommended SARS-CoV-2 assay analyzed epidemiology CARVs.Nasopharyngeal/oropharyngeal swabs (NOPS) from 7663 patients were prospectively tested Basel S-gene WHO-based E-gene (Roche) assays parallel using N-gene for confirmation....