A5057108840- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Advanced X-ray and CT Imaging
- Venous Thromboembolism Diagnosis and Management
- Viral Infections and Immunology Research
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Imaging Techniques and Applications
- Pericarditis and Cardiac Tamponade
- Cardiomyopathy and Myosin Studies
- Coronary Artery Anomalies
- Cardiovascular Disease and Adiposity
- Infective Endocarditis Diagnosis and Management
- Congenital Heart Disease Studies
- Cardiovascular Effects of Exercise
- Cardiac tumors and thrombi
- Takotsubo Cardiomyopathy and Associated Phenomena
University Hospital of Basel
2016-2025
University of Basel
2012-2025
Cardiovascular Institute Hospital
2025
Siemens Healthcare (Germany)
2024
Hospital Base
2021-2024
Hôpital de Morges
2021
University Hospital of Lausanne
2021
University of Lausanne
2021
Hirslanden Klinik Im Park
2021
Luzerner Kantonsspital
2021
High-sensitivity cardiac troponin (hs-cTn) assays seem to improve the early diagnosis of acute myocardial infarction (AMI), but it is unknown how best use them in clinical practice. Our objective was develop and validate an algorithm for rapid rule-out rule-in AMI.A prospective multicenter study enrolling 872 unselected patients with chest pain presenting emergency department. T (hs-cTnT) measured a blinded fashion at presentation after 1 hour. The final adjudicated by 2 independent...
Background— Current guidelines for the diagnosis of acute myocardial infarction (AMI), among other criteria, also require a rise and/or fall in cardiac troponin (cTn) levels. It is unknown whether absolute or relative changes cTn have higher diagnostic accuracy and should therefore be preferred. Methods Results— In prospective, observational, multicenter study, we analyzed (Δ) (Δ%) 836 patients presenting to emergency department with symptoms suggestive AMI. Blood samples determination...
Abstract
AimsTo examine the diagnostic accuracy of sensitive cardiac troponin (cTn) assays in elderly patients, since elevated levels with cTn were reported 20% patients without acute myocardial infarction (AMI).
<h3>Background:</h3> We aimed to prospectively validate a novel 1-hour algorithm using high-sensitivity cardiac troponin T measurement for early rule-out and rule-in of acute myocardial infarction (MI). <h3>Methods:</h3> In multicentre study, we enrolled 1320 patients presenting the emergency department with suspected MI. The algorithm, incorporating baseline values as well absolute changes within first hour, was validated against final diagnosis. diagnosis then adjudicated by 2 independent...
It is unknown whether cardiac troponin (cTn) I or cTnT the preferred biomarker in early diagnosis of acute myocardial infarction without ST segment elevation (NSTEMI).In a prospective multicentre study, we measured cTnI and using clinically available high-sensitivity assays (hs-cTnI Abbott hs-cTnT Roche) compared their diagnostic prognostic accuracies consecutive patients presenting to emergency department with chest pain. The final was adjudicated by two independent cardiologists all...
We hypothesized that high-sensitivity cardiac troponin (hs-cTn) and its early change are useful in distinguishing acute myocardial infarction (AMI) from noncoronary artery disease.In a prospective, international multicenter study, hs-cTn was measured with 3 assays (hs-cTnT, Roche Diagnostics; hs-cTnI, Beckman-Coulter; hs-cTnI Siemens) blinded fashion at presentation serially thereafter 887 unselected patients chest pain. Accuracy of the combination values serial changes compared against...
Whether sex-specific chest pain characteristics (CPCs) would allow physicians in the emergency department to differentiate women with acute myocardial infarction (AMI) from other causes of more accurately remains unknown. OBJECTIVE To improve management suspected AMI by exploring CPCs.From April 21, 2006, through August 12, 2012, we enrolled 2475 consecutive patients (796 and 1679 men) presenting 9 departments a prospective multicenter study. The final diagnosis was adjudicated 2 independent...
Abstract Objectives To address the diagnostic value of circulating micro RNA s (mi s) in patients presenting with acute chest pain. Design In a prospective, international, multicentre study, six mi (miR‐133a, miR‐208b, miR‐223, miR‐320a, miR‐451 and miR‐499) were simultaneously measured blinded fashion 1155 unselected pain to emergency department. The final diagnosis was adjudicated by two independent cardiologists. clinical follow‐up period 2 years. Results Acute myocardial infarction ( AMI...
Background— Misdiagnosis of acute myocardial infarction (AMI) may significantly harm patients and result from inappropriate clinical decision values (CDVs) for cardiac troponin (cTn) owing to limitations in the current regulatory process. Methods Results— In an international, prospective, multicenter study, we quantified incidence inconsistencies diagnosis AMI using fully characterized clinically available high-sensitivity (hs) cTn assays (hs-cTnI, Abbott; hs-cTnT, Roche) among 2300...
Cardiac troponin (cTn) T and cTnI are considered cardiac specific equivalent in the diagnosis of acute myocardial infarction. Previous studies suggested rare skeletal myopathies as a noncardiac source cTnT. We aimed to confirm reliability/cardiac specificity cTnT patients with various muscle disorders (SMDs).We prospectively enrolled presenting muscular complaints (≥2 weeks) for elective evaluation 4 hospitals 2 countries. After workup, were adjudicated into 3 predefined disease categories....
To explore the incidence and potential mechanisms of oligosymptomatic myocardial injury following COVID-19 mRNA booster vaccination.Hospital employees scheduled to undergo mRNA-1273 vaccination were assessed for vaccination-associated injury, defined as acute dynamic increase in high-sensitivity cardiac troponin T (hs-cTnT) concentration above sex-specific upper limit normal on day 3 (48-96 h) after without evidence an alternative cause. possible mechanisms, antibodies against interleukin-1...
We sought to examine the diagnostic and prognostic utility of sensitive cardiac troponin (cTn) assays in patients with pre-existing coronary artery disease (CAD). conducted a multicentre study accuracy one high-sensitive two cTn 1098 consecutive presenting symptoms suggestive acute myocardial infarction (AMI), whom 401 (37%) had CAD. Measurements Roche cTnT (hs-cTnT), Siemens cTnI-Ultra, Abbott-Architect cTnI standard assay (Roche cTnT) were performed blinded fashion. The final diagnosis was...
Several high-sensitivity cardiac troponin (hs-cTn) assays have recently been developed. It is unknown which hs-cTn provides the most accurate prognostic information and to what extent early changes in predict mortality. In a prospective, international multicentre study, cTn was simultaneously measured with three novel [high-sensitivity Troponin T (hs-cTnT), Roche Diagnostics; hs-cTnI, Beckman-Coulter; Siemens] conventional assay (cTnT, Diagnostics) blinded fashion 1117 unselected patients...