Ivo Strebel
A5019052043- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrhythmias and Treatments
- ECG Monitoring and Analysis
- Coronary Interventions and Diagnostics
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Hemodynamic Monitoring and Therapy
- Emergency and Acute Care Studies
- Cardiac Health and Mental Health
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Aortic aneurysm repair treatments
- Hip and Femur Fractures
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Advanced MRI Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Chronic Disease Management Strategies
University Hospital of Basel
2017-2025
University of Basel
2017-2024
Cardiovascular Institute Hospital
2017-2024
Hospital Base
2018-2024
University Hospital of Bern
2019-2021
Kantonsspital Aarau
2020
ETH Zurich
2015
École Polytechnique Fédérale de Lausanne
2014
Perioperative myocardial injury (PMI) seems to be a contributor mortality after noncardiac surgery. Because the vast majority of PMIs are asymptomatic, PMI usually is missed in absence systematic screening. We performed prospective diagnostic study enrolling consecutive patients undergoing surgery who had planned postoperative stay ≥24 hours and were considered at increased cardiovascular risk. All received screening using serial measurements high-sensitivity cardiac troponin T clinical...
Abstract Aims Perioperative myocardial infarction/injury (PMI) following non-cardiac surgery is a frequent cardiac complication. Better understanding of the underlying aetiologies and outcomes urgently needed. Methods results Aetiologies PMIs detected within an active surveillance response programme were centrally adjudicated by two independent physicians based on all information obtained during clinically indicated PMI work-up including imaging among consecutive high-risk patients...
The European Society of Cardiology recommends a 0/1-hour algorithm for rapid rule-out and rule-in non-ST-segment elevation myocardial infarction using high-sensitivity cardiac troponin (hs-cTn) concentrations irrespective renal function. Because patients with dysfunction (RD) frequently present increased hs-cTn even in the absence infarction, concern has been raised regarding performance RD. In prospective multicenter diagnostic study enrolling unselected presenting suspected to emergency...
Until now, high-sensitivity cardiac troponin (hs-cTn) assays were mainly developed for large central laboratory platforms. This study aimed to assess the clinical performance of a point-of-care (POC)-hs-cTnI assay in patients with suspected myocardial infarction (MI). enrolled presenting emergency department symptoms suggestive MI. Two cardiologists centrally adjudicated final diagnosis using all data including imaging. The primary objective was directly compare diagnostic accuracy...
We aimed to evaluate the impact of age on performance European Society Cardiology (ESC) 0/1h-algorithms and derive externally validate alternative cut-offs specific older patients.We prospectively enrolled patients presenting emergency department (ED) with symptoms suggestive acute myocardial infarction in three large diagnostic studies. Final diagnoses were adjudicated by two independent cardiologists. High-sensitivity cardiac troponin (hs-cTn) T I concentrations measured at presentation...
Major adverse cardiac events (MACE) triggered by non-cardiac surgery are prognostically important perioperative complications. However, due to often asymptomatic presentation, the incidence and timing of postoperative MACE incompletely understood.
The aim of this study was to validate the clinical performance Beckman Access high-sensitivity cardiac troponin I (hs-cTnI) assay.We enrolled patients presenting emergency department with symptoms suggestive acute myocardial infarction (AMI). Final diagnoses were centrally adjudicated by 2 independent cardiologists all information including imaging twice: first, using serial hs-cTnT (Elecsys, primary analysis), and second, hs-cTnI (Architect, secondary analysis) measurements in addition...
Cardiac troponin (cTn) T and cTnI are considered cardiac specific equivalent in the diagnosis of acute myocardial infarction. Previous studies suggested rare skeletal myopathies as a noncardiac source cTnT. We aimed to confirm reliability/cardiac specificity cTnT patients with various muscle disorders (SMDs).We prospectively enrolled presenting muscular complaints (≥2 weeks) for elective evaluation 4 hospitals 2 countries. After workup, were adjudicated into 3 predefined disease categories....
Collaboration for the Diagnosis and Evaluation of Acute Coronary Syndrome (CoDE-ACS) is a validated clinical decision support tool that uses machine learning with or without serial cardiac troponin measurements at flexible time point to calculate probability myocardial infarction (MI). How CoDE-ACS performs different points measurement compares guideline-recommended diagnostic pathways rely on fixed thresholds uncertain.
Background: Combining 2 signals of cardiomyocyte injury, cardiac troponin I (cTnI) and T (cTnT), might overcome some individual pathophysiological analytical limitations thereby increase diagnostic accuracy for acute myocardial infarction with a single blood draw. We aimed to evaluate the performance combinations high-sensitivity (hs) cTnI hs-cTnT early diagnosis infarction. Methods: The combining hs-cTnI (Architect, Abbott) (Elecsys, Roche) concentrations (sum, product, ratio, combination...
Abstract BACKGROUND We aimed to validate the clinical performance of high-sensitivity cardiac troponin I [VITROS® Immunodiagnostic Products hs Troponin (hs-cTnI-VITROS)] assay. METHODS enrolled patients presenting emergency department with symptoms suggestive acute myocardial infarction (AMI). Final diagnoses were centrally adjudicated by 2 independent cardiologists considering all information, including imaging: first, using serial hs-cTnT-Elecsys (primary analysis) and, second,...
Background: The utility of BNP (B-type natriuretic peptide), NT-proBNP (N-terminal proBNP), and hs-cTn (high-sensitivity cardiac troponin) concentrations for diagnosis risk-stratification syncope is incompletely understood. Methods: We evaluated the diagnostic prognostic accuracy BNP, NT-proBNP, hs-cTnT, hs-cTnI concentrations, alone against those clinical assessments, in patients >45-years old presenting with to emergency department a prospective multicenter study. hs-cTnT were measured...
Background: The MEESSI-AHF (Multiple Estimation of risk based on the Emergency department Spanish Score In patients with AHF) score was developed to predict 30-day mortality in presenting acute heart failure (AHF) emergency departments (EDs) Spain. Whether it performs well other countries is unknown. Objective: To externally validate another country. Design: Prospective cohort study. (ClinicalTrials.gov: NCT01831115). Setting: Multicenter recruitment dyspneic ED. Participants: external...
Background: The non–ST-segment–elevation myocardial infarction (NSTEMI) guidelines of the European Society Cardiology (ESC) recommend a 3h cardiac troponin determination in patients triaged to observe-zone ESC 0/1h-algorithm; however, no specific cutoff for further triage is endorsed. Recently, 0/3h high-sensitivity T (hs-cTnT) change (7 ng/L) was proposed, warranting external validation. Methods: Patients presenting with acute chest discomfort emergency department were prospectively...
IMPORTANCEIn contrast to type 1 myocardial infarction (T1MI) caused by atherothrombosis, characteristics and outcomes of 2 (T2MI) supply-demand mismatch are incompletely understood.OBJECTIVE To explore the patients with T2MI compared those T1MI. DESIGN, SETTING, AND PARTICIPANTSIn a prospective, international, multicenter cohort study including 12 emergency departments (EDs) in 5 European countries, unselected presenting acute chest discomfort were enrolled from April 2006 2018.Follow-up was...
Abstract Functionally relevant coronary artery disease (fCAD) can result in premature death or nonfatal acute myocardial infarction. Its early detection is a fundamentally important task medicine. Classical approaches suffer from limited diagnostic accuracy expose patients to possibly harmful radiation. Here we show how machine learning (ML) outperform cardiologists predicting the presence of stress-induced fCAD terms area under receiver operating characteristic (AUROC: 0.71 vs. 0.64, p =...
Abstract Introduction Pulmonary transit time (PTT) is the it takes blood to pass from right ventricle left via pulmonary circulation, making a potentially useful marker for heart failure. We assessed association of PTT with diastolic dysfunction and mitral valve regurgitation. Methods evaluated routine stress perfusion cardiovascular magnetic resonance (CMR) scans in 83 patients including assessment simultaneously available echocardiographic assessment. Relevant (DD) regurgitation (MVR) were...