A5031579667- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- Long-Term Effects of COVID-19
- Angiogenesis and VEGF in Cancer
- Air Quality Monitoring and Forecasting
- Venous Thromboembolism Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- COVID-19 Clinical Research Studies
- Cardiovascular Disease and Adiposity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cerebrovascular and Carotid Artery Diseases
- Vehicle emissions and performance
- Energy and Environment Impacts
- Cardiac Arrest and Resuscitation
- Cardiac Health and Mental Health
- Cardiovascular Effects of Exercise
University of Edinburgh
2016-2025
British Heart Foundation
2016-2025
NHS Lothian
2012-2025
Institute of Population and Public Health
2025
Edinburgh Royal Infirmary
2013-2024
Health Data Research UK
2020-2024
St Vincent’s Private Hospital Sydney
2024
The Queen's Medical Research Institute
2011-2024
Edinburgh College
2020-2024
Wayne State University
2022-2024
The use of non-invasive imaging to identify ruptured or high-risk coronary atherosclerotic plaques would represent a major clinical advance for prevention and treatment artery disease. We used combined PET CT using the radioactive tracers (18)F-sodium fluoride ((18)F-NaF) (18)F-fluorodeoxyglucose ((18)F-FDG).In this prospective trial, patients with myocardial infarction (n=40) stable angina underwent (18)F-NaF (18)F-FDG PET-CT, invasive angiography. uptake was compared histology in carotid...
Air pollution has wide-ranging and deleterious effects on human health is a major issue for the global community. The Global Burden of Disease study described worldwide impact air with as many 3.1 million 52.8 all-cause all-age deaths being attributable to ambient in year 2010.1 Moreover, ranked ninth among modifiable disease risk factors, listed above other commonly recognized such low physical activity, high-sodium diet, high cholesterol, drug use. Finally, accounts 3.1%...
Exposure to air pollution from traffic is associated with adverse cardiovascular events. The mechanisms for this association are unknown. We conducted a controlled exposure dilute diesel exhaust in patients stable coronary heart disease determine the direct effect of on myocardial, vascular, and fibrinolytic function.
Background— Although the mechanisms are unknown, it has been suggested that transient exposure to traffic-derived air pollution may be a trigger for acute myocardial infarction. The study aim was investigate effects of diesel exhaust inhalation on vascular and endothelial function in humans. Methods Results— In double-blind, randomized, cross-over study, 30 healthy men were exposed diluted (300 μg/m 3 particulate concentration) or 1 hour during intermittent exercise. Bilateral forearm blood...
Abstract Although myocarditis and pericarditis were not observed as adverse events in coronavirus disease 2019 (COVID-19) vaccine trials, there have been numerous reports of suspected cases following vaccination the general population. We undertook a self-controlled case series study people aged 16 or older vaccinated for COVID-19 England between 1 December 2020 24 August 2021 to investigate hospital admission death from myocarditis, cardiac arrhythmias 1–28 days adenovirus (ChAdOx1, n =...
The development of engineered nanomaterials is growing exponentially, despite concerns over their potential similarities to environmental nanoparticles that are associated with significant cardiorespiratory morbidity and mortality. mechanisms through which inhalation could trigger acute cardiovascular events emerging, but a fundamental unanswered question remains: Do inhaled translocate from the lung in man directly contribute pathogenesis disease? In complementary clinical experimental...
The future risk of myocardial infarction is commonly assessed using cardiovascular scores, coronary artery calcium score, or stenosis severity. We whether noncalcified low-attenuation plaque burden on CT angiography (CCTA) might be a better predictor the infarction.
Suspected acute coronary syndrome is the commonest reason for emergency admission to hospital and a large burden on health-care resources. Strategies identify low-risk patients suitable immediate discharge would have major benefits.We did prospective cohort study of 6304 consecutively enrolled with suspected presenting four secondary tertiary care hospitals in Scotland. We measured plasma troponin concentrations at presentation using high-sensitivity cardiac I assay. In derivation validation...
Abstract Aims To describe the cardiac abnormalities in patients with COVID-19 and identify characteristics of who would benefit most from echocardiography. Methods results In a prospective international survey, we captured echocardiography findings presumed or confirmed between 3 20 April 2020. Patient characteristics, indications, findings, impact on management were recorded. Multivariable logistic regression identified predictors echocardiographic abnormalities. A total 1216 [62 (52–71)...
<b>Objective</b> To evaluate the diagnosis of myocardial infarction using a high sensitivity troponin I assay and sex specific diagnostic thresholds in men women with suspected acute coronary syndrome. <b>Design</b> Prospective cohort study. <b>Setting</b> Regional cardiac centre, United Kingdom. <b>Participants</b> Consecutive patients syndrome (n=1126, 46% women). Two cardiologists independently adjudicated by (men 34 ng/L, 16 ng/L) compared current practice where contemporary (50 single...
Exposure to combustion-derived air pollution is associated with an early (1-2 h) and sustained (24 rise in cardiovascular morbidity mortality. We have previously demonstrated that inhalation of diesel exhaust causes immediate (within 2 impairment vascular endothelial function humans.To investigate the systemic effects humans 24 hours after inhalation.Fifteen healthy men were exposed (particulate concentration, 300 microg/m(3)) or filtered for 1 hour a double-blind, randomized, crossover...
High-sensitivity cardiac troponin assays permit use of lower thresholds for the diagnosis myocardial infarction, but whether this improves clinical outcomes is unknown. We aimed to determine introduction a high-sensitivity I (hs-cTnI) assay with sex-specific 99th centile diagnostic threshold would reduce subsequent infarction or cardiovascular death in patients suspected acute coronary syndrome.In stepped-wedge, cluster-randomised controlled trial across ten secondary tertiary care hospitals...
Although troponin assays have become increasingly more sensitive, it is unclear whether further reductions in the threshold of detection for plasma concentrations will improve clinical outcomes patients with suspected acute coronary syndrome (ACS).To determine lowering diagnostic myocardial infarction (MI) a sensitive assay could outcomes.All consecutive admitted ACS to Royal Infirmary Edinburgh, Scotland, before (n = 1038; February 1-July 31, 2008, during validation phase) and after 1054;...
Type 2 myocardial infarction and injury are common in clinical practice, but long-term consequences uncertain. We aimed to define outcomes explore risk stratification patients with type injury.
Although the mechanism is unclear, exposure to traffic-derived air pollution a trigger for acute myocardial infarction (MI). The aim of this study investigate effect diesel exhaust inhalation on platelet activation and thrombus formation in men.In double-blind randomized crossover study, 20 healthy volunteers were exposed dilute (350 microg/m(3)) filtered air. Thrombus formation, coagulation, activation, inflammatory markers measured at 2 6 h following exposure. was using Badimon ex vivo...
Data regarding high-sensitivity troponin concentrations in patients presenting to the emergency department with symptoms suggestive of myocardial infarction may be useful determining probability and subsequent 30-day outcomes.