A5004308174- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Acute Myocardial Infarction Research
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Aortic aneurysm repair treatments
- Ultrasound in Clinical Applications
- Medical Imaging Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac tumors and thrombi
- Cardiovascular Effects of Exercise
- Aortic Thrombus and Embolism
- Cardiac Arrhythmias and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- Congenital Heart Disease Studies
University of Edinburgh
2018-2025
British Heart Foundation
2019-2025
Edinburgh Royal Infirmary
2018-2024
Edinburgh College
2020
British Heart Foundation Centre for Cardiovascular Science
2020
The Queen's Medical Research Institute
2019
Concord Repatriation General Hospital
2014-2018
The University of Sydney
2014-2016
Stanford Medicine
2015
Tianjin University
2009
Abstract Aims To describe the cardiac abnormalities in patients with COVID-19 and identify characteristics of who would benefit most from echocardiography. Methods results In a prospective international survey, we captured echocardiography findings presumed or confirmed between 3 20 April 2020. Patient characteristics, indications, findings, impact on management were recorded. Multivariable logistic regression identified predictors echocardiographic abnormalities. A total 1216 [62 (52–71)...
Valvular calcification is central to the pathogenesis and progression of aortic stenosis, with preclinical observational studies suggesting that bone turnover osteoblastic differentiation valvular interstitial cells are important contributory mechanisms. We aimed establish whether inhibition these pathways denosumab or alendronic acid could reduce disease in stenosis.
Despite improvements in management, infective endocarditis remains associated with high mortality and morbidity. We describe temporal changes the incidence, microbiology, outcomes of effect national antibiotic prophylaxis guidelines on incident endocarditis.Using a Scotland-wide, individual-level linkage approach, all patients hospitalized from 1990 to 2014 were identified linked prescribing, morbidity datasets. Linked data used evaluate trends crude age- sex-adjusted incidence...
Within the SCOT-HEART (Scottish COmputed Tomography of HEART Trial) trial patients with stable chest pain, use coronary computed tomography angiography (CTA) reduced rate death from heart disease or nonfatal myocardial infarction (primary endpoint). This study sought to assess consistency and mechanisms 5-year reduction in this endpoint. In open-label trial, 4,146 participants were randomized standard care alone plus CTA. explored primary endpoint by symptoms, diagnosis, revascularizations,...
The optimal timing of aortic valve replacement in asymptomatic patients with stenosis is uncertain. Replacement fibrosis, as assessed by midwall (nonischemic) late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging, an irreversible marker left ventricular decompensation stenosis. Once established, it progresses rapidly and associated poor long-term prognosis a dose-dependent manner.The objective this multicenter prospective randomized controlled trial to determine...
Objectives Non-contrast CT aortic valve calcium scoring ignores the contribution of valvular fibrosis in stenosis. We assessed calcific and non-calcific disease using contrast-enhanced CT. Methods This was a post hoc analysis 164 patients (median age 71 (IQR 66–77) years, 78% male) with stenosis (41 mild, 89 moderate, 34 severe; 7% bicuspid) who underwent echocardiography as part imaging studies. Calcific (fibrosis) tissue volumes were quantified indexed to annulus area, Hounsfield unit...
Myocardial fibrosis is the heart's common healing response to injury. While initially seeking optimize strength of diseased tissue, can become maladaptive, producing stiff poorly functioning and pro-arrhythmic myocardium. Different patterns are associated with different myocardial disease states, but presence quantity largely confer adverse prognosis. Current imaging techniques assess extent pattern scarring, lack specificity detect established when window modify this process may have ended....
Importance Myocardial fibrosis in aortic stenosis (AS) may exhibit sex differences. However, its prognostic significance women with AS remains unclear. Objective To investigate differences myocardial assessed by cardiovascular magnetic resonance (CMR) and evaluate value men AS. Design, Setting, Participants Patients severe who underwent CMR before valve replacement (AVR) were prospectively enrolled from 13 international sites between March 2011 September 2021. was evaluated using...
Background Positron emission tomography (PET) using 18 F-sodium fluoride ( F-fluoride) to detect microcalcification may provide insight into disease activity in coronary atherosclerosis. This study aimed investigate the relationship between F-fluoride uptake and progression of calcification patients with clinically stable artery disease. Methods Patients established multivessel atherosclerosis underwent PET-computed angiography computed calcium scoring, repeat scoring at one year. Coronary...
Recent European guidance supports a diminished role for exercise electrocardiography (ECG) in the assessment of suspected stable angina.To evaluate utility ECG contemporary practice and assess value combined functional anatomical testing.This is post hoc analysis Scottish Computed Tomography Heart (SCOT-HEART) open-label randomized clinical trial, conducted 12 cardiology chest pain clinics across Scotland patients with angina secondary to coronary heart disease. Between November 18, 2010,...
Major uncertainties remain regarding disease activity within the retained native aortic valve, and bioprosthetic valve durability, after transcatheter implantation (TAVI). We aimed to assess durability in patients with TAVI comparison subjects surgical replacement (SAVR).In a multicenter cross-sectional observational cohort study, or SAVR underwent baseline echocardiography, computed tomography angiography, 18F-sodium fluoride (18F-NaF) positron emission tomography. Participants (n=47) were...
Aortic atherosclerosis represents an important contributor to ischemic stroke risk. Identifying patients with high-risk aortic atheroma could improve preventative treatment strategies for future stroke.The purpose of this study was investigate whether thoracic 18F-sodium fluoride positron emission tomography (PET) the identification at highest risk stroke.In a post hoc observational cohort study, we quantified and coronary activity in 461 stable cardiovascular disease undergoing PET combined...
Background Important disparities in the treatment and outcomes of women men with atrial fibrillation (AF) are well recognized. Whether introduction direct oral anticoagulants has reduced is uncertain. Methods Results All patients who had an incident hospitalization from 2010 to 2019 nonvalvular AF Scotland were included present cohort study. Community drug dispensing data used determine prescribed anticoagulation therapy comorbidity status. Logistic regression modeling was evaluate patient...
Aortic stenosis (AS) is characterized by calcification and fibrosis. The ability to quantify these processes simultaneously has been limited with previous imaging methods. purpose of this study was evaluate the aortic valve fibrocalcific volume computed tomography (CT) angiography in patients AS, particular, assess its reproducibility, association histology disease severity, predict/track progression. In 136 calculated on CT angiograms at baseline after 1 year. attenuation distributions were...
Background: Coronary 18 F-fluoride positron emission tomography identifies ruptured and high-risk atherosclerotic plaque. The optimal method to identify, quantify, categorize increased coronary uptake determine its reproducibility has yet be established. This study aimed optimize the identification, quantification, categorization, scan-rescan of activity in Methods: In a prospective observational study, patients with multi-vessel artery disease underwent serial tomography. was visually...