A5012900736- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Advanced X-ray and CT Imaging
- Cardiovascular Disease and Adiposity
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Vasculitis and related conditions
- Ultrasound in Clinical Applications
- Eosinophilic Disorders and Syndromes
- Phonocardiography and Auscultation Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Urologic and reproductive health conditions
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Effects of Exercise
- Lipoproteins and Cardiovascular Health
- Health and Well-being Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac tumors and thrombi
- Aortic Thrombus and Embolism
- Cardiovascular Health and Disease Prevention
- Genetic and rare skin diseases.
Icahn School of Medicine at Mount Sinai
2015-2025
University of Duisburg-Essen
2025
Ferdowsi University of Mashhad
2025
Mount Sinai Hospital
2017-2024
University of Ottawa
2023
Iran University of Medical Sciences
2022
University of British Columbia
2009-2021
Mount Sinai Hospital
2016-2021
St. Paul's Hospital
2018-2021
University of Social Welfare and Rehabilitation Sciences
2016-2020
AimsCoronary plaque characteristics are associated with ischaemia. Differences in volumes and composition may explain the discordance between coronary stenosis severity We evaluated association severity, characteristics, computed tomography angiography (CTA)-derived fractional flow reserve (FFRCT), lesion-specific ischaemia identified by FFR a substudy of NXT trial (Analysis Coronary Blood Flow Using CT Angiography: Next Steps).
Obstructive coronary lesions with reduced luminal dimensions may result in abnormal regional myocardial blood flow as assessed by stress-induced perfusion imaging or a significant fall distal pressure hyperemia-induced vasodilatation (fractional reserve [FFR] ≤0.80). An FFR has been demonstrated to identify high-risk benefitting from percutaneous intervention while safely allowing revascularization be deferred low-risk lesions, resulting decrease the number of procedures well substantially...
Within the SCOT-HEART (Scottish COmputed Tomography of HEART Trial) trial patients with stable chest pain, use coronary computed tomography angiography (CTA) reduced rate death from heart disease or nonfatal myocardial infarction (primary endpoint). This study sought to assess consistency and mechanisms 5-year reduction in this endpoint. In open-label trial, 4,146 participants were randomized standard care alone plus CTA. explored primary endpoint by symptoms, diagnosis, revascularizations,...
Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond components remains unknown. This study compared the prevalence, severity coronary artery (CAD), prognosis patients to those individual components. The cohort consisted 27125 consecutive individuals who underwent ≥64-detector row CT angiography (CCTA) at 12 centers from 2003 2009. Metabolic was defined as per NCEP/ATP III criteria. (n=690) were matched 1:1:1 1...
BACKGROUND: Luminal stenosis, computed tomography–derived fractional-flow reserve (FFR CT ), and high-risk plaque features on coronary tomography angiography are all known to be associated with adverse clinical outcomes. The interactions between these variables, patient outcomes, quantitative volumes have not been previously described. METHODS: Patients (n=4430) one-year outcome data from the international ADVANCE (Assessing Diagnostic Value of Noninvasive FFR in Coronary Care) registry...
Coronary computed tomography angiography provides non-invasive assessment of coronary stenosis severity and flow impairment. Automated artificial intelligence (AI) analysis may assist in precise quantification characterization atherosclerosis, enabling patient-specific risk determination management strategies. This multicentre international study compared an automated deep learning-based method for segmenting atherosclerosis (CCTA) against the reference standard intravascular ultrasound (IVUS).
Background— Age-adjusted coronary artery disease (CAD) burden identified on computed tomography angiography predicts major adverse cardiovascular event (MACE) risk; however, it seldom contributes to clinical decision making because of a lack nomographic data. We aimed develop clinically pragmatic age- and sex-specific nomograms CAD using validate their prognostic use. Methods Results— Patients prospectively enrolled in phase I the CONFIRM registry (Coronary CT Angiography Evaluation for...
We hypothesize that in patients with suspected coronary artery disease (CAD), lower values of the ratio total epicardial arterial lumen volume to left ventricular myocardial mass (V/M) result fractional flow reserve (FFR).V/M was computed 238 from NXT trial who underwent tomography angiography (CTA), quantitative (QCA) and FFR measurement 438 vessels. Nitroglycerin administered prior CT, QCA acquisition. The V/M quantified on a patient-level CT image data by segmenting (V) (M). Calcified...
Post-stroke early activation of neutrophils contributes to intensive neuroinflammation and worsens disease outcomes. Other pre-existing patient conditions can modify the extent their during disease, especially hypercholesterolemia. However, whether how increased circulating cholesterol amounts change neutrophil responses very after stroke has not been studied. In this study, we investigated effect high-fat diet (HFD) induced hypercholesterolemia on outcome. Mice were fed with HFD or normal...
To determine the clinical outcomes of women and men with nonobstructive coronary artery disease ( CAD ) computed tomographic (CT) angiography data in patients who were similar terms risk factors, angina typicality, extent distribution.