Sang‐Eun Lee
A5100755142- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Agriculture, Soil, Plant Science
- Cardiovascular Health and Disease Prevention
- Lipoproteins and Cardiovascular Health
- Medical Imaging Techniques and Applications
- Parasitic Infections and Diagnostics
- Herpesvirus Infections and Treatments
- Radiation Dose and Imaging
- Nutrition, Health and Food Behavior
- Technology and Data Analysis
- Toxoplasma gondii Research Studies
- Korean Urban and Social Studies
- Blood Pressure and Hypertension Studies
- Consumer Perception and Purchasing Behavior
- Cultural and Historical Studies
- Pulmonary Hypertension Research and Treatments
- Prostate Cancer Diagnosis and Treatment
Ewha Womans University
2008-2025
Yonsei University
2013-2024
University of Illinois Chicago
2024
University of Ulsan
2023-2024
Asan Medical Center
2023-2024
Ulsan College
2023-2024
Seoul National University
2006-2024
Seoul St. Mary's Hospital
2024
Andong National University
2023
University College London
2023
The density of atherosclerotic plaque forms the basis for categorizing calcified and noncalcified morphology plaques.To assess whether alterations in across a range measurements provide more detailed understanding disease progression.This cohort study enrolled 857 patients who underwent serial coronary computed tomography angiography 2 or years apart had quantitative plaques throughout entire artery tree. was conducted from 2013 to 2016 at 13 sites 7 countries.The main outcome progression...
<h3>Importance</h3> Plaque morphologic measures on coronary computed tomography angiography (CCTA) have been associated with future acute syndrome (ACS). However, the evolution of calcified plaques by noninvasive imaging is not known. <h3>Objective</h3> To ascertain whether increasing density in plaque risk for ACS. <h3>Design, Setting, and Participants</h3> This multicenter case-control cohort study included individuals enrolled ICONIC (Incident Coronary Syndromes Identified Computed...
Background: Diagnosis of coronary artery disease and management strategies have relied solely on the presence diameter stenosis ≥50%. We assessed whether direct quantification plaque burden (PB) characteristics by computed tomography angiography could provide additional value in terms predicting rapid progression. Methods Results: From a 13-center, 7-country prospective observational registry, 1345 patients (60.4±9.4 years old; 57.1% male) who underwent repeated >2 apart were enrolled....
Insulin resistance (IR) is an important risk factor for subclinical atherosclerosis. This study evaluated the relationship between triglyceride glucose (TyG) index, which a simple and reliable surrogate marker IR, arterial stiffness.This included 2560 Korean subjects without previous history of coronary artery disease, stroke, malignancies who participated in community-based cohort study. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV).All participants were...
Abstract Aims Coronary artery calcium score (CACS) is a strong predictor of major adverse cardiac events (MACE). Conversely, statins, which markedly reduce MACE risk, increase CACS. We explored whether CACS progression represents compositional plaque volume (PV) differently according to statin use. Methods and results From prospective multinational registry consecutive patients (n = 2252) who underwent serial coronary computed tomography angiography (CCTA) at ≥ 2-year interval, 654 (61 ± 10...
Background Rapid coronary plaque progression (RPP) is associated with incident cardiovascular events. To date, no method exists for the identification of individuals at risk RPP a single point in time. This study integrated computed tomography angiography-determined qualitative and quantitative features within machine learning (ML) framework to determine its performance predicting RPP. Methods Results Qualitative angiography characterization was performed 1083 patients who underwent serial...
We aimed to investigate whether long-term exposure particulate matter with an aerodynamic diameter <2.5 μm (PM2.5) in the ambient air is related development or growth of coronary plaques.This study involved 364 residents Seoul, Korea, who underwent serial computed tomographic angiography (CCTA) at interval ≥2 years. Each participant's average concentration residential PM2.5 between two CCTAs was calculated. Primary endpoint high-risk plaque (HRP), defined as a low attenuation, spotty...
In patients with stable coronary artery disease (CAD) and high-risk plaques (HRPs) on computed tomography angiography (CTA), we sought to define qualitative quantitative CTA predictors of abnormal 18F-sodium fluoride uptake (18F-NaF) by positron emission (PET).Patients undergoing were screened for HRP. Those who presented ≥3 adverse plaque features (APFs) including positive remodelling; low attenuation (LAP, <30 HU), spotty calcification; obstructive stenosis ≥50%; volume >100 mm3 recruited...
We assessed whether combinations of cardiometabolic risk factors independently predict coronary plaque progression (PP) and major adverse cardiovascular events in patients with stable artery disease.
We tested the hypothesis that chronic treatment with sildenafil attenuates left ventricular (LV) remodeling and prevents exercise intolerance in mitral regurgitation (MR).MR was created Sprague-Dawley rats by making a hole on leaflet. Two weeks after MR creation, LV dilatation were confirmed echocardiography, randomly assigned to (MR+sildenafil group; 50 mg/kg PO twice day; n=16) or normal saline only (MR continued for 4 months. Sixteen sham compared rats. After months, size smaller...
High mobility group box-1 (HMGB1), a proinflammatory cytokine, plays pivotal role in tissue remodeling and angiogenesis, both of which are crucial for the pathogenesis pulmonary arterial hypertension. In this study, we explored relationship between HMGB1 hypertension whether glycyrrhizin, an inhibitor HMGB1, attenuates disease progression animal model induced by monocrotaline sodium (MCT).After inducing through single subcutaneous injection MCT (60 mg/kg) to Sprague-Dawley rats, administered...
<h3>Background</h3> Apical hypertrophic cardiomyopathy (ApHCM) is considered a 'benign' form of cardiomyopathy, with limited data on the long-term outcome. However, clinical impact atrial fibrillation (AF) in ApHCM largely unknown. The hypothesis was that AF common and has prognostic implication ApHCM. <h3>Methods</h3> occurrence outcome assessed 306 consecutive patients (68% male, 62±11 years). <h3>Results</h3> occurred 77 (prevalence, 25.2%; annual incidence, 4.6%/year) independently...
The inhibitors of CD26 (dipeptidyl peptidase-4; DPP4) have been widely prescribed to control glucose level in diabetic patients. DPP4-inhibitors, however, accumulate stromal cell-derived factor-1α (SDF-1α), a well-known inducer vascular leakage and angiogenesis both which are fundamental pathophysiology retinopathy. aim this study was investigate the effects DPP4-inhibitors on permeability DPP4-inhibitor (diprotin A or sitagliptin) increased phosphorylation Src endothelial-cadherin...