A5039146544- Cardiac Imaging and Diagnostics
- Anesthesia and Pain Management
- Coronary Interventions and Diagnostics
- Cardiac Ischemia and Reperfusion
- Nausea and vomiting management
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Acute Myocardial Infarction Research
- Anesthesia and Neurotoxicity Research
- Advanced X-ray and CT Imaging
- Sarcoma Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Ion Channels and Receptors
- Cerebrovascular and Carotid Artery Diseases
- Neurofibromatosis and Schwannoma Cases
- Cardiac tumors and thrombi
- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Intensive Care Unit Cognitive Disorders
- COVID-19 and healthcare impacts
Central South University
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Renji Hospital
2021-2025
Shanghai Jiao Tong University
2021-2025
Peking University First Hospital
2025
Peking University
2025
Anhui Medical University
2015-2024
First Affiliated Hospital of Anhui Medical University
2009-2024
Yale University
2024
Xuzhou Medical College
2020-2024
Symptom-based pretest probability scores that estimate the likelihood of obstructive coronary artery disease (CAD) in stable chest pain have moderate accuracy. We sought to develop a machine learning (ML) model, utilizing clinical factors and calcium score (CACS), predict presence CAD on computed tomography angiography (CCTA).
The density of atherosclerotic plaque forms the basis for categorizing calcified and noncalcified morphology plaques.To assess whether alterations in across a range measurements provide more detailed understanding disease progression.This cohort study enrolled 857 patients who underwent serial coronary computed tomography angiography 2 or years apart had quantitative plaques throughout entire artery tree. was conducted from 2013 to 2016 at 13 sites 7 countries.The main outcome progression...
Abstract Objective To test the hypothesis that a freeze-all strategy would increase chance of live birth compared with fresh embryo transfer in women low prognosis for vitro fertilisation (IVF) treatment. Design Pragmatic, multicentre, randomised controlled trial. Setting Nine academic fertility centres China. Participants 838 IVF treatment defined by ≤9 oocytes retrieved or poor ovarian reserve (antral follicle count <5 serum anti-Müllerian hormone level <8.6 pmol/L). Interventions...
<h3>Importance</h3> Plaque morphologic measures on coronary computed tomography angiography (CCTA) have been associated with future acute syndrome (ACS). However, the evolution of calcified plaques by noninvasive imaging is not known. <h3>Objective</h3> To ascertain whether increasing density in plaque risk for ACS. <h3>Design, Setting, and Participants</h3> This multicenter case-control cohort study included individuals enrolled ICONIC (Incident Coronary Syndromes Identified Computed...
Stress imaging has been the standard for diagnosing functionally significant coronary artery disease. It is unknown whether novel, atherosclerotic plaque measures improve accuracy beyond stenosis invasive fractional flow reserve (FFR) measurement.To compare diagnostic of comprehensive anatomic (obstructive and nonobstructive plaque) vs functional estimating vessel-specific FFR.Controlled clinical trial with a multicenter derivation-validation cohort patients referred nonemergent angiography....
There are no known effective medical treatments for refractory MPNST. Inactivation of the NF1 tumor suppressor in MPNST results upregulation mTOR (mammalian target rapamycin) signaling and angiogenesis, which contributes to disease progression. We conducted a phase II study patients (pts) with combining everolimus (10 mg PO once daily) bevacizumab mg/kg IV every 2 weeks) determine clinical benefit rate (CBR) (complete response, partial response (PR), or stable (SD) ≥ 4 months).Patients ≥18...
Abstract Aims In patients without obstructive coronary artery disease (CAD), we examined the prognostic value of risk factors and atherosclerotic extent. Methods results Patients from long-term CONFIRM registry prior CAD (≥50%) stenosis were included. Within groups normal computed tomography angiography (CCTA) (N = 1849) non-obstructive 1698), traditional clinical extent (segment involvement score, SIS) was assessed with Cox models. Major adverse cardiac events (MACE) defined as all-cause...
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas. Combining Hsp90 inhibitors to enhance endoplasmic reticulum stress with mTOR inhibition results in dramatic MPNST shrinkage a genetically engineered mouse model. Ganetespib is an injectable potent small molecule inhibitor of Hsp90. Sirolimus oral inhibitor. We sought determine the safety, tolerability, and recommended dose ganetespib sirolimus patients refractory sarcomas assess clinical benefits...
The extent to which health care systems have adapted the COVID-19 pandemic provide necessary cardiac diagnostic services is unknown. aim of this study was determine impact on testing practices, volumes and types services, perceived psychological stress providers worldwide. International Atomic Energy Agency conducted a worldwide survey assessing alterations from baseline in cardiovascular at pandemic's onset 1 year later. Multivariable regression used factors associated with procedure volume...
Respiring mitochondria drive the electrophoretic uptake of K+ and other cations. In presence permeant acids this transport leads to mitochondrial swelling if it is not compensated by electroneutral K+/H+ exchange mediated antiporter. The mechanism influx has yet be established; however, evidence accumulating that in addition leak pathways a specific channel or uniporter may involved. We examine some properties uniport which are consistent with existence ATP-regulated channel. contrast...
The transient receptor potential vanilloid 1 (TRPV1) mediates cellular responses to pain, heat, or noxious stimuli by calcium influx; however, the localization and function of TRPV1 in cardiomyocyte is largely unknown. We studied whether myocardial injury regulated we could mitigate reperfusion limiting calcineurin interaction with TRPV1.In primary cardiomyocytes, confocal electron microscopy demonstrates that localized mitochondria. Capsaicin, specific agonist, dose-dependently reduced...
Abstract Aims High-risk plaque (HRP) and non-obstructive coronary artery disease independently predict adverse events, but their importance to future culprit lesions has not been resolved. We sought determine in patients prior confirmed acute syndrome (ACS) the association between lesion percent diameter stenosis (%DS), absolute number prevalence of HRP. The secondary objective was examine relative HRP lesions. Methods results Within ICONIC study, a nested case–control study undergoing...