Alexander R. van Rosendael
A5040287240- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Advanced X-ray and CT Imaging
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Cardiac Arrhythmias and Treatments
- Coronary Artery Anomalies
- Cardiac electrophysiology and arrhythmias
- Blood Pressure and Hypertension Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Imaging Techniques and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Health and Risk Factors
- Radiation Dose and Imaging
- Acute Ischemic Stroke Management
- Atherosclerosis and Cardiovascular Diseases
- Peripheral Artery Disease Management
Leiden University Medical Center
2016-2025
Leiden University
2018-2022
NewYork–Presbyterian Hospital
2018-2022
Cornell University
2018-2022
Weill Cornell Medicine
2018-2022
Presbyterian Hospital
2018-2022
New York Hospital Queens
2018-2022
Netherlands Heart Institute
2015-2017
Turku PET Centre
2017
Liverpool Hospital
2017
Symptom-based pretest probability scores that estimate the likelihood of obstructive coronary artery disease (CAD) in stable chest pain have moderate accuracy. We sought to develop a machine learning (ML) model, utilizing clinical factors and calcium score (CACS), predict presence CAD on computed tomography angiography (CCTA).
The density of atherosclerotic plaque forms the basis for categorizing calcified and noncalcified morphology plaques.To assess whether alterations in across a range measurements provide more detailed understanding disease progression.This cohort study enrolled 857 patients who underwent serial coronary computed tomography angiography 2 or years apart had quantitative plaques throughout entire artery tree. was conducted from 2013 to 2016 at 13 sites 7 countries.The main outcome progression...
<h3>Importance</h3> Plaque morphologic measures on coronary computed tomography angiography (CCTA) have been associated with future acute syndrome (ACS). However, the evolution of calcified plaques by noninvasive imaging is not known. <h3>Objective</h3> To ascertain whether increasing density in plaque risk for ACS. <h3>Design, Setting, and Participants</h3> This multicenter case-control cohort study included individuals enrolled ICONIC (Incident Coronary Syndromes Identified Computed...
Percutaneous transcatheter tricuspid valve therapy is an evolving treatment option for patients with significant regurgitation (TR) deemed too fragile open heart surgery. The present study proposes comprehensive anatomical evaluation of the valve, right ventricle (RV), and vena cavae its spatial relationships coronary artery (RCA) using computed tomography (CT) investigates implications suitability current technologies. A total 250 (mean age 80 ± 7.2 years, 52.4% men) undergoing CT were...
Background The ability to accurately predict the occurrence of in-hospital death after percutaneous coronary intervention is important for clinical decision-making. We sought utilize New York Percutaneous Coronary Intervention Reporting System in order elucidate determinants mortality patients undergoing across State. Methods and Results examined 479 804 between 2004 2012, utilizing traditional advanced machine learning algorithms determine most significant predictors mortality. entire data...
Background Rapid coronary plaque progression (RPP) is associated with incident cardiovascular events. To date, no method exists for the identification of individuals at risk RPP a single point in time. This study integrated computed tomography angiography-determined qualitative and quantitative features within machine learning (ML) framework to determine its performance predicting RPP. Methods Results Qualitative angiography characterization was performed 1083 patients who underwent serial...
Pericoronary adipose tissue (PCAT) attenuation has been associated with coronary inflammation and can be evaluated computed tomography angiography. The aims of this study were to compare the PCAT across precursors culprit nonculprit lesions patients acute syndrome versus stable artery disease (CAD).In case-control study, suspected CAD who underwent angiography included. Patients developed an within 2 years after scan identified, (defined as any plaque ≥30% luminal diameter stenosis) 1:2...
Importance Lipoprotein(a) (Lp[a]) is a causal risk factor for cardiovascular disease; however, long-term effects on coronary atherosclerotic plaque phenotype, high-risk formation, and pericoronary adipose tissue inflammation remain unknown. Objective To investigate the association of Lp(a) levels with artery progression, plaque, inflammation. Design, Setting, Participants This single-center prospective cohort study included 299 patients suspected disease (CAD) who underwent per-protocol...
Noninvasive stress testing is commonly used for detection of coronary ischemia but possesses variable accuracy and may result in excessive health care costs. This study aimed to derive validate an artificial intelligence-guided quantitative computed tomography angiography (AI-QCT) model the diagnosis that integrates atherosclerosis vascular morphology measures (AI-QCTISCHEMIA) evaluate its prognostic utility major adverse cardiovascular events (MACE). A post hoc analysis CREDENCE (Computed...
Stress imaging has been the standard for diagnosing functionally significant coronary artery disease. It is unknown whether novel, atherosclerotic plaque measures improve accuracy beyond stenosis invasive fractional flow reserve (FFR) measurement.To compare diagnostic of comprehensive anatomic (obstructive and nonobstructive plaque) vs functional estimating vessel-specific FFR.Controlled clinical trial with a multicenter derivation-validation cohort patients referred nonemergent angiography....
Abstract Aims In patients without obstructive coronary artery disease (CAD), we examined the prognostic value of risk factors and atherosclerotic extent. Methods results Patients from long-term CONFIRM registry prior CAD (≥50%) stenosis were included. Within groups normal computed tomography angiography (CCTA) (N = 1849) non-obstructive 1698), traditional clinical extent (segment involvement score, SIS) was assessed with Cox models. Major adverse cardiac events (MACE) defined as all-cause...
Background Progression of coronary artery disease using serial computed tomography angiography (CTA) is clinical interest. Our primary aim was to prospectively assess the impact characteristics and statin use on quantitatively assessed plaque progression in a low-risk study population during long-term follow-up. Methods Patients who previously underwent CTA for suspected were included undergo follow-up CTA. The end point progression, defined as absolute annual increase total, calcified,...
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Abstract Aims High-risk plaque (HRP) and non-obstructive coronary artery disease independently predict adverse events, but their importance to future culprit lesions has not been resolved. We sought determine in patients prior confirmed acute syndrome (ACS) the association between lesion percent diameter stenosis (%DS), absolute number prevalence of HRP. The secondary objective was examine relative HRP lesions. Methods results Within ICONIC study, a nested case–control study undergoing...
Left atrial (LA) volume and LA epicardial fat are both substrates for fibrillation (AF), but may relate with AF at different (early vs. late) stages in the disease process. We evaluated associations between patients sinus rhythm (SR), paroxysmal (PAF), persistent/permanent AF.In total, 300 (100 SR, 100 PAF, AF) who underwent cardiac computed tomography angiography (CTA) were included. The mass posterior to quantified from CTA compared AF. Furthermore, four groups created by classifying into...
Epicardial adipose tissue located close to the atrial wall can change electric conduction of left atrium, potentially leading fibrillation (AF). The aim this study was assess whether an increased mass posterior atrium is related AF independent demographical and cardiovascular risk factors.Two hundred patients with 200 without who underwent computed tomographic angiography were included. quantified on images as Hounsfield Units between -195 -45. significantly larger in compared sinus rhythm:...