A5028993103- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Advanced MRI Techniques and Applications
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Cardiac, Anesthesia and Surgical Outcomes
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Vascular Procedures and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Pulmonary Hypertension Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
Vrije Universiteit Amsterdam
2011-2025
Amsterdam University Medical Centers
2018-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2016-2025
University of Amsterdam
2020-2025
Amsterdam Neuroscience
2020-2024
All India Institute of Medical Sciences
2024
Amsterdam UMC Location University of Amsterdam
2011-2023
George Washington University
2023
Minneapolis Heart Institute Foundation
2023
Seoul National University Hospital
2023
At present, the choice of noninvasive testing for a diagnosis significant coronary artery disease (CAD) is ambiguous, but nuclear myocardial perfusion imaging with single-photon emission tomography (SPECT) or positron (PET) and computed angiography (CCTA) predominantly used this purpose. However, to date, prospective head-to-head studies are lacking regarding diagnostic accuracy these modalities. Furthermore, combination anatomical functional assessments configuring hybrid approach may yield...
Imaging-guided percutaneous coronary intervention (PCI) is associated with better clinical outcomes than angiography-guided PCI. Whether routine optical coherence tomography (OCT) guidance in PCI of lesions involving coronary-artery branch points (bifurcations) improves as compared angiographic uncertain. Download a PDF the Research Summary. We conducted multicenter, randomized, open-label trial at 38 centers Europe. Patients indication for and complex bifurcation lesion identified by means...
Clinical reads of coronary computed tomography angiography (CTA), especially by less experienced readers, may result in overestimation artery disease stenosis severity compared with expert interpretation. Artificial intelligence (AI)-based solutions applied to CTA overcome these limitations.This study the performance for detection and grading stenoses using artificial intelligence-enabled quantitative (AI-QCT) analyses core lab-interpreted CTA, lab (QCA), invasive fractional flow reserve...
Abstract Aims Current risk scores do not accurately identify patients at highest of recurrent atherosclerotic cardiovascular disease (ASCVD) in need more intensive therapeutic interventions. Advances high-throughput plasma proteomics, analysed with machine learning techniques, may offer new opportunities to further improve stratification these patients. Methods and results Targeted proteomics was performed two secondary prevention cohorts: the Second Manifestations ARTerial (SMART) cohort (n...
The aim of this study was to compare Doppler flow velocity and thermodilution-derived indexes determine the optimal thermodilution-based diagnostic thresholds for coronary reserve (CFR). majority clinical data flow-based are derived from measurements, correspondence with indices remain unclear. An international multicenter registry conducted among patients who had measurements using both thermodilution techniques in same vessel during procedure. Physiological 250 vessels (in 149 patients)...
Background: Coronary microvascular dysfunction (CMD) is an important contributor to angina syndromes.Recently, two distinct endotypes were identified using combined assessment of coronary flow reserve (CFR) and minimal resistance (MR), termed structural functional CMD. Aims:We aimed assess the relevance CFR MR in patients with no obstructive arteries.Methods: Patients chronic syndromes (CCS) non-obstructive artery disease (fractional [FFR] ≥0.80) selected (N=1,102).Functional CMD was defined...
The microvascular resistance reserve (MRR) was introduced as a means to characterize the vasodilator capacity of coronary microcirculation while accounting for influence concomitant epicardial disease and impact administration potent vasodilators on aortic pressure. This study aimed evaluate diagnostic prognostic performance MRR.A total 1481 patients with stable symptoms clinical indication angiography were included from global ILIAS Registry. MRR derived function flow (CFR) divided by...
The recent development of artificial intelligence–guided quantitative coronary computed tomography angiography (CCTA) analysis (AI-QCT) has enabled rapid atherosclerotic plaque burden and characteristics. This study set out to investigate the 10-year prognostic value derived from AI-QCT compare spectrum manually assessed CCTA, artery calcium scoring (CACS), clinical risk was a long-term follow-up 536 patients referred for suspected disease. CCTA scans were analyzed with classified staging...
Lack of gadolinium-contrast wash-in on first-pass perfusion imaging, early gadolinium-enhanced or late (LGE) cardiovascular magnetic resonance (CMR) imaging after revascularized ST-elevation myocardial infarction (STEMI) is commonly referred to as microvascular obstruction (MVO). Additionally, T2-weighted allows for the visualization infarct-related oedema and intramyocardial haemorrhage (IMH) within infarction. However, exact histopathological correlate contrast-devoid core its relation IMH...
Parametric imaging of absolute myocardial blood flow (MBF) using [(15)O]H(2)O enables determination MBF with high spatial resolution. The aim this study was to develop a method for generating reproducible, high-quality and quantitative parametric images minimal user intervention.Nineteen patients referred evaluation underwent rest adenosine stress positron emission tomography (PET) scans. Ascending aorta right ventricular (RV) cavity volumes interest (VOIs) were used as input functions....
Our understanding of human coronary physiological behaviour is derived from animal models. We sought to describe across a large collection invasive pressure and flow velocity measurements, provide better the relationships between these parameters evaluate rationale for resting stenosis assessment.Five hundred sixty-seven simultaneous intracoronary assessments 301 patients were analysed velocity, trans-stenotic gradient (TG), microvascular resistance (MVR). Measurements made during baseline...
<h3>Objective</h3> Sudden cardiac death is a major cause of mortality in patients with ischaemic cardiomyopathy. Risk stratification remains challenging. Currently, there growing interest scar characteristic assessment as predictor sudden using magnetic resonance imaging (CMR). Standard analysis methods are lacking. The present study evaluated previously validated by CMR late gadolinium enhancement (LGE) their ability to predict ventricular tachyarrhythmias. <h3>Methods</h3> Patients...