A5065258380- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Cardiovascular Function and Risk Factors
- Dementia and Cognitive Impairment Research
- Drug Transport and Resistance Mechanisms
- Advanced X-ray and CT Imaging
- Alzheimer's disease research and treatments
- Lung Cancer Treatments and Mutations
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- Neuroscience and Neuropharmacology Research
- Lanthanide and Transition Metal Complexes
- Coronary Interventions and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiomyopathy and Myosin Studies
- Functional Brain Connectivity Studies
- Cardiovascular Disease and Adiposity
- S100 Proteins and Annexins
- Cerebrovascular and Carotid Artery Diseases
- Rheumatoid Arthritis Research and Therapies
Amsterdam UMC Location Vrije Universiteit Amsterdam
2015-2025
University of Groningen
2021-2025
University Medical Center Groningen
2020-2025
Amsterdam University Medical Centers
2009-2024
Vrije Universiteit Amsterdam
2013-2024
Amsterdam Neuroscience
2014-2023
Copenhagen University Hospital
2022-2023
Amyloidosis Foundation
2023
Society of Nuclear Medicine and Molecular Imaging
2021
University College London
1984-2020
The aim of this guideline is to provide a minimum standard for the acquisition and interpretation PET PET/CT scans with [18F]-fluorodeoxyglucose (FDG). This will therefore address general information about[18F]-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) provided help physician physicist assist carrying out,interpret, document quantitative FDG examinations,but concentrate on optimisation diagnostic quality information.
Regional cerebral blood flow (CBF), oxygen extraction ratio (OER), utilization (CMRO2) and volume (CBV) were measured in a group of 34 healthy volunteers (age range 22-82 yrs) using the 15O steady-state inhalation method positron emission tomography. Between subjects CBF correlated positively with CMRO2, although interindividual variability values was large. OER not dependent on but highly negatively CBF. CBV When considering all regions interest within single subject, strict coupling...
In order to localize cerebral cognitive or sensorimotor function, activation paradigms are being used in conjunction with PET measures of activity (e.g., rCBF). The changes local have two components: a global, region independent change and regional change. As the first step localizing effects an activation, global variance must be removed by normalization procedure. A simple procedure is division values whole brain mean. This requires dependence on one proportionality. shown not case....
Five different methods for the estimation of binding potential, a measure B max /K d , [ 11 C]raclopride in human striatum were compared using data from dose ranging study neuroleptic CP-88,059-01. Binding potential was estimated indirectly, distribution volumes and cerebellum, both single- two-tissue compartment models with metabolite-corrected plasma curve as input function. The model also used direct estimate potential. In addition, obtained reference tissue cerebellum indirect Finally,...
At present, the choice of noninvasive testing for a diagnosis significant coronary artery disease (CAD) is ambiguous, but nuclear myocardial perfusion imaging with single-photon emission tomography (SPECT) or positron (PET) and computed angiography (CCTA) predominantly used this purpose. However, to date, prospective head-to-head studies are lacking regarding diagnostic accuracy these modalities. Furthermore, combination anatomical functional assessments configuring hybrid approach may yield...
The ECAT high resolution research tomograph (HRRT) is a dedicated brain and small animal PET scanner, with design features that enable image spatial combined sensitivity. HRRT the first commercially available scanner utilizes double layer of LSO/LYSO crystals to achieve photon detection depth-of-interaction information. In this study, performance commercial was characterized, using NEMA protocol as guideline. Besides measurement resolution, energy sensitivity, scatter fraction, count rate...
Current strategies combining anti-angiogenic drugs with chemotherapy provide clinical benefit in cancer patients. It is assumed that drugs, such as bevacizumab, transiently normalize abnormal tumor vasculature and contribute to improved delivery of subsequent chemotherapy. To investigate this concept, a study was performed non-small cell lung (NSCLC) patients using positron emission tomography (PET) radiolabeled docetaxel ([11C]docetaxel). In NSCLC, bevacizumab reduced both perfusion net...
A major pathological hallmark of Alzheimer's disease is accumulation amyloid-β in senile plaques the brain. Evidence accumulating that decreased clearance from brain may lead to these elevated levels. One pathways transport across blood–brain barrier via efflux transporters. P-glycoprotein, an pump highly expressed at endothelial cells barrier, has been shown amyloid-β. P-glycoprotein function can be assessed vivo using (R)-[11C]verapamil and positron emission tomography. The aim this study...
Abstract Purpose This joint practice guideline or procedure standard was developed collaboratively by the European Association of Nuclear Medicine (EANM) and Society Molecular Imaging (SNMMI). The goal this is to assist nuclear medicine practitioners in recommending, performing, interpreting, reporting results dopaminergic imaging parkinsonian syndromes. Methods Currently investigations can assess both presynaptic postsynaptic function synapses. To date EANM SNMMI have published procedural...
The present procedural guidelines summarize the current views of EANM Neuro-Imaging Committee (NIC). purpose these is to assist nuclear medicine practitioners in making recommendations, performing, interpreting, and reporting results [18F]FDG-PET imaging brain. aim help achieve a high-quality standard [18F]FDG brain further increase diagnostic impact this technique neurological, neurosurgical, psychiatric practice. document replaces former version that have been published 2009. These new...
PURPOSE: Variable uptake of the glucose analog 18 fluorodeoxyglucose (FDG) has been noticed in positron emission tomography (PET) studies breast cancer patients, with low occurring especially lobular cancer. At present, no satisfactory biologic explanation exists for this phenomenon. This study compared FDG vivo biomarkers expected to be involved underlying mechanisms. PATIENTS AND METHODS: Preoperative FDG-PET scans were performed 55 patients. activity was assessed visually by three...
The oxygen-15 steady-state inhalation technique provides quantitative values of regional cerebral blood flow, fractional oxygen extraction, and utilisation. These last two, however, have been found to be higher than those reported using arteriovenous difference techniques. On theoretical grounds, this overestimation is due the signal from nonextracted intravascular oxygen-15. In paper, a method presented correct for component utilising measurement volume. statistical penalty imposed as...