A5049513985- CAR-T cell therapy research
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Cancer Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- Colorectal Cancer Treatments and Studies
- Health Systems, Economic Evaluations, Quality of Life
- Estrogen and related hormone effects
- Advances in Oncology and Radiotherapy
- Clinical practice guidelines implementation
- Radiomics and Machine Learning in Medical Imaging
- Bladder and Urothelial Cancer Treatments
- Drug Transport and Resistance Mechanisms
- Chemotherapy-related skin toxicity
- Cancer, Hypoxia, and Metabolism
- Hair Growth and Disorders
- HER2/EGFR in Cancer Research
- Diet and metabolism studies
- Radiopharmaceutical Chemistry and Applications
Radboud University Medical Center
2016-2023
Leiden University Medical Center
2013-2023
Radboud University Nijmegen
2016-2023
Hartwig Medical Foundation
2020-2023
Netherlands Comprehensive Cancer Organisation
2022
University Medical Center
2020
Leiden University
2016-2019
Medisch Centrum Alkmaar
2009-2015
Amsterdam UMC Location University of Amsterdam
2013
Ziekenhuis Amstelland
2004-2008
Abstract Short-term fasting protects tumor-bearing mice against the toxic effects of chemotherapy while enhancing therapeutic efficacy. We randomized 131 patients with HER2-negative stage II/III breast cancer, without diabetes and a BMI over 18 kg m −2 , to receive either mimicking diet (FMD) or their regular for 3 days prior during neoadjuvant chemotherapy. Here we show that there was no difference in toxicity between both groups, despite fact dexamethasone omitted FMD group. A...
PURPOSE: Variable uptake of the glucose analog 18 fluorodeoxyglucose (FDG) has been noticed in positron emission tomography (PET) studies breast cancer patients, with low occurring especially lobular cancer. At present, no satisfactory biologic explanation exists for this phenomenon. This study compared FDG vivo biomarkers expected to be involved underlying mechanisms. PATIENTS AND METHODS: Preoperative FDG-PET scans were performed 55 patients. activity was assessed visually by three...
Purpose Patients with adenocarcinoma of unknown primary origin (ACUP) constitute approximately 4% all malignancies. For effective treatment these patients, it is considered optimal to identify the tumor origins. Currently, success rate diagnostic work-up only 20% 30%. Our goal was evaluate contribution gene expression profiling for routine clinical practice in patients ACUP. and Methods Formalin-fixed, paraffin-embedded (FFPE) samples were obtained from 84 a known 38 An extensive...
There are no universally monitored outcomes relevant to men with advanced prostate cancer, making it challenging compare health between populations. We sought develop a standard set of cancer follow during routine clinical care. The International Consortium for Health Outcomes Measurement assembled multidisciplinary working group the set. used modified Delphi method achieve consensus regarding outcomes, measures, and case mix factors included. 25 members international represented academic...
Whole genome sequencing (WGS) using fresh-frozen tissue and matched blood samples from cancer patients may become the most complete genetic tumor test. With increasing availability of small biopsies need to screen more number biomarkers, use a single all-inclusive test is preferable over multiple consecutive assays. To meet high-quality diagnostics standards, we optimized clinically validated WGS sample data processing procedures, resulting in technical success rate 95.6% for with sufficient...
To prospectively evaluate the effect of adding whole-body (18)F-2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) to conventional screening for distant metastases in patients with locally advanced breast cancer (LABC).All women LABC referred participation Spinoza trial were considered eligible this study. Patients included if chest x-ray, bone scan, liver ultrasound, or computed scan performed by referring physician failed reveal metastases. They underwent FDG PET scanning...
Docetaxel is an important chemotherapeutic agent used for the treatment of several cancer types. As radiolabelled anticancer agents provide a potential means personalized planning, docetaxel was labelled with positron emitter 11C. Non-invasive measurements [11C]docetaxel uptake in organs and tumours may additional information on pharmacokinetics pharmacodynamics drug docetaxel. The purpose present study to determine biodistribution radiation absorbed dose humans. Biodistribution measured...
Mammalian target of rapamycin (mTOR) upregulation has been reported to be involved in the pathogenesis thyroid tumors, and treatment with mTOR inhibitor everolimus shown promising results endocrine tumors. We conducted a prospective phase II clinical trial determine efficacy safety patients advanced follicular-derived cancer. Twenty-eight progressive metastatic or locally radioactive refractory differentiated cancer 7 anaplastic were included received 10 mg orally once daily. The primary...
// Eveline M. Dijkgraaf 1 , Saskia J.A.M. Santegoets An K.L. Reyners 2 Renske Goedemans Hans W. Nijman 3 Mariëtte I.E. van Poelgeest 4 Arien R. Erkel 5 Vincent T.H.B.M. Smit 6 Toos A.H.H. Daemen 7 Jacobus J.M. der Hoeven Cornelis Melief 8 Marij J.P. Welters Judith Kroep 1, * Sjoerd H. Burg Department of Medical Oncology, Leiden University Center, 2333 ZA, Leiden, The Netherlands Clinical Center Groningen, 9713 GZ, Gynecologic Gynecology, Radiology, Pathology, Microbiology, Immunohematology...
Abstract Purpose In the phase II DIRECT study a fasting mimicking diet (FMD) improved clinical response to neoadjuvant chemotherapy as compared regular diet. Quality of Life (QoL) and illness perceptions regarding possible side effects FMD were secondary outcomes trial. Methods 131 patients with HER2-negative stage II/III breast cancer recruited, whom 129 randomly assigned (1:1) receive either or their for 3 days prior day chemotherapy. The European Organisation Research Treatment Cancer...
To prospectively investigate determinants of the accuracy staging axillary lymph nodes in breast cancer using [F-18]fluorodeoxyglucose positron emission tomography (FDG PET).Patients with primary operable underwent FDG PET chest followed by sentinel node biopsy (SNB, n = 47) and/or complete dissection (ALND, 23). scans were independently interpreted three observers a blinded fashion respect to avidity tumor and status. The results compared histopathological analyses nodes. Clinicians...
Background Serum levels of 25-OH vitamin D3 (vitamin D) have been shown to be prognostic for disease-free survival in patients with breast cancer. We investigated the predictive value these pathological response after neoadjuvant chemotherapy cancer taking part NEOZOTAC phase-III trial. Additionally, effect on D was studied. Materials and methods measured at baseline before last cycle chemotherapy. The relationship between measurements clinical outcome, as defined by complete lymph nodes...
Abstract Background ‘Precision oncology’ can ensure the best suitable treatment at right time by tailoring towards individual patient and comprehensive tumour characteristics. In current molecular pathology, diagnostic tests which are part of standard care (SOC) only cover a limited spectrum genomic changes, often performed in an iterative way. This occurs expense valuable time, available tissue sample, interferes with ‘first right’ decisions. Whole Genome Sequencing (WGS) captures near...
•A WGS-based cancer of unknown primary prediction algorithm was developed and validated on a pan-cancer database (n = 4509).•The tumor type correctly predicted in 78% samples an independent validation cohort (194/254).•High-confidence predictions (>95%) were obtained for 162/254 patients (64%).•A identified 68% 72 CUP when CUPPA prospectively applied routine work-up.•Actionable events with matched therapy options clinical trials 47% (34/72) CUP.•In the Netherlands, WGS is now reimbursed...
The purpose of this study was to investigate the cardioprotective effect semisynthetic flavonoid 7-monohydroxyethylrutoside (monoHER) on doxorubicin (DOX)-induced cardiotoxicity in a phase II patients with metastatic cancer. Eight cancer were treated DOX preceded by 10 min i.v. infusion 1500 mg m(-2) monoHER. Five examined endomyocardial biopsy after reaching cumulative dose 300 m(-2). Histopathological changes cardiomyocytes (Billingham score) compared those described literature for only....
Gallium is antiproliferative to many types of cancer, due primarily its ability act as a non-functional mimic ferric iron (Fe(3+)). Because Fe(3+) needed for ribonucleotide reductase activity--and thus DNA synthesis--gallium can inhibit production and cell division. Diagnostic gallium scans have shown that hepatocellular carcinoma (HCC) commonly avid gallium. Furthermore, in vitro studies found nitrate, particularly maltolate (GaM), dose-dependent activity against HCC lines. Rationale exists...