A5048152930- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Breast Cancer Treatment Studies
- Estrogen and related hormone effects
- Colorectal Cancer Screening and Detection
- Advanced Breast Cancer Therapies
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Anorectal Disease Treatments and Outcomes
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- BRCA gene mutations in cancer
- Gene expression and cancer classification
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Risks and Factors
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Global Cancer Incidence and Screening
- Cancer-related cognitive impairment studies
- Bone health and treatments
Leiden University Medical Center
2016-2025
Leiden University
2002-2023
NXP (Netherlands)
2023
Philips (Netherlands)
2023
Champalimaud Foundation
2022
The Netherlands Cancer Institute
2010-2022
Roche (Switzerland)
2022
Novartis (Switzerland)
2022
AstraZeneca (France)
2022
Eisai (Japan)
2022
In Brief Objective: To investigate the efficacy of preoperative short-term radiotherapy in patients with mobile rectal cancer undergoing total mesorectal excision (TME) surgery. Summary Background Data: Local recurrence is a major problem treatment. Preoperative has shown to improve local control and survival combination conventional The TME trial investigated value this regimen excision. Long-term results are reported after median follow-up 6 years. Methods: One thousand eight hundred...
Preoperative short-term radiotherapy improves local control in patients treated with total mesorectal excision (TME). This study was performed to assess the presence and magnitude of long-term side effects preoperative 5 x Gy TME. Also, hospital treatment recorded for diseases possibly related late rectal cancer treatment.Long-term morbidity assessed from prospective randomized TME trial, which investigated efficacy before surgery mobile cancer. Dutch without recurrent disease were sent a...
The extent of lymph node dissection appropriate for gastric cancer is still under debate. We have conducted a randomized trial to compare the results limited (D1) and extended (D2) in terms morbidity, mortality, long-term survival cumulative risk relapse. reviewed our after follow-up more than 10 years.Between August 1989 June 1993, 1,078 patients with adenocarcinoma were randomly assigned undergo D1 or D2 dissection. Data collected prospectively, followed years.A total 711 (380 group 331...
Despite improved surgical treatment strategies for rectal cancer, 5–15% of all patients will develop local recurrences. After conservative surgery, circumferential resection margin (CRM) involvement is a strong predictor recurrence. The consequences positive CRM after total mesorectal excision (TME) have not been evaluated in large patient population. In nationwide randomized multicenter trial comparing preoperative radiotherapy and TME versus alone was determined according to protocol. this...
Abstract Background Anastomotic leakage is a major complication of rectal cancer surgery. The aim this study was to investigate risk factors associated with symptomatic anastomotic after total mesorectal excision (TME). Methods Between 1996 and 1999, patients operable were randomized receive short-term radiotherapy followed by TME or undergo alone. Eligible Dutch who underwent an anterior resection (924 patients) studied retrospectively. Results Symptomatic occurred in 107 (11·6 per cent)....
Few prospective studies have been performed about the impact of preoperative radiotherapy (PRT) or total mesorectal excision (TME) on health-related quality life (HRQL) and sexual functioning in patients with resectable rectal cancer. This report describes HRQL 990 who underwent TME were randomly assigned to short-term PRT (5 x 5 Gy).The Rotterdam Symptom Check List supplemented additional items was used questionnaires before treatment at 3, 6, 12, 18, 24 months after surgery. Patients...
PURPOSE: Total mesorectal excision (TME) surgery in the treatment of rectal cancer has been shown to result a reduction number local recurrences retrospective studies. Reports on improved control after preoperative, hypofractionated radiotherapy (RT) have led introduction prospective randomized multicenter trial, which effect TME with or without preoperative RT were evaluated. Any benefit regard reduced recurrence rate and possible survival must be weighed against potential adverse effects...
We investigated very long-term bowel function after total mesorectal excision (TME) with or without preoperative short-course radiotherapy (PRT) for rectal cancer, the risk factors dysfunction, and association of dysfunction health-related quality life (HRQL).In TME trial (1996-1999), 1530 Dutch patients cancer were randomized to preceded by 5 × Gy PRT alone. A set questionnaires was sent surviving (n = 583) in 2012. The included Low Anterior Resection Syndrome Score (LARS score), European...
Abstract Short-term fasting protects tumor-bearing mice against the toxic effects of chemotherapy while enhancing therapeutic efficacy. We randomized 131 patients with HER2-negative stage II/III breast cancer, without diabetes and a BMI over 18 kg m −2 , to receive either mimicking diet (FMD) or their regular for 3 days prior during neoadjuvant chemotherapy. Here we show that there was no difference in toxicity between both groups, despite fact dexamethasone omitted FMD group. A...
Abstract Liquid biopsies are providing new opportunities for detection of residual disease in cell-free DNA (cfDNA) after surgery but may be confounded through identification alterations arising from clonal hematopoiesis. Here, we identify circulating tumor-derived (ctDNA) ultrasensitive targeted sequencing analyses matched cfDNA and white blood cells the same patient. We apply this approach to analyze samples patients CRITICS trial, a phase III randomized controlled study perioperative...
Objective: To analyze risk and patterns of locoregional failure (LRF) in patients the RAPIDO trial at 5 years. Background: Multimodality treatment improves local control rectal cancer. Total neoadjuvant (TNT) aims to improve systemic while is maintained. At 3 years, LRF rate was comparable between TNT chemoradiotherapy trial. Methods: A total 920 were randomized an experimental (EXP, short-course radiotherapy, chemotherapy, surgery) a standard-care group (STD, chemoradiotherapy, surgery,...
The optimal duration of extended endocrine therapy beyond five years after initial aromatase inhibitor-based adjuvant for postmenopausal women with hormone receptor-positive breast cancer is still unknown. Therefore, we conducted a clinical trial to compare two different durations.In the randomized phase III IDEAL trial, patients were randomly allocated either 2.5 or letrozole any therapy. primary end point was disease free survival (DFS), and secondary points overall (OS), distant...
Background A pathological complete response (pCR) following chemoradiation (CRT) or short-course radiotherapy (scRT) leads to a favourable prognosis in patients with rectal cancer. Total neo-adjuvant therapy (TNT) doubles the pCR rate, but it is unknown whether oncological outcomes remain and same characteristics are associated as after CRT. Methods Comparison between RAPIDO trial experimental [EXP] (scRT, chemotherapy, surgery, TNT) standard-of-care treatment [STD] (CRT, postoperative...
PURPOSE: In retrospective studies, total mesorectal excision (TME) surgery has been demonstrated to result in a reduction the number of local recurrences rectal cancer. Reports on improved control after preoperative, hypofractionated radiotherapy have led introduction randomized multicenter trial evaluate effect TME with and without preoperative radiotherapy. Treatment might an pathologic characteristics that determine staging We investigated occurrence downstaging cancer patients treated...
Epstein-Barr virus (EBV) is detected in a substantial subgroup of gastric adenocarcinomas worldwide. We have previously reported that these EBV-positive carcinomas carry distinct genomic aberrations. In the present study, we analyzed large cohort and EBV-negative for their clinicopathologic features to determine whether they constitute different clinical entity.Using validated polymerase chain reaction/enzyme immunoassay-based prescreening method combination with EBER1/2-RNA situ...
Western patients with gastric cancer often present incurable disease. The role of palliative surgical resection is still debatable. Non-curatively treated from the Dutch Gastric Cancer Trial were studied to define more accurately which might benefit resection.In 285 (26 per cent) randomized found have tumours at laparotomy. Four signs incurability noted: irresectable tumour (T+), hepatic metastasis (H+), peritoneal (P+) and distant lymph node (N4+). Patients had either an explorative...