A5022594489- Gastric Cancer Management and Outcomes
- Nutrition and Health in Aging
- Colorectal Cancer Surgical Treatments
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Frailty in Older Adults
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Appendicitis Diagnosis and Management
- Hernia repair and management
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Screening and Detection
- Pelvic and Acetabular Injuries
- Organ Transplantation Techniques and Outcomes
- Congenital Anomalies and Fetal Surgery
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- RNA Interference and Gene Delivery
- Congenital Diaphragmatic Hernia Studies
- Gastrointestinal disorders and treatments
- Body Composition Measurement Techniques
- Xenotransplantation and immune response
- Colorectal and Anal Carcinomas
Zuyderland Medisch Centrum
2016-2025
Weatherford College
2024
University Medical Center Utrecht
2021-2022
University Hospital Heidelberg
2021
University of Amsterdam
2021
Dutch Cancer Society
2021
Heidelberg University
2021
Amsterdam University Medical Centers
2021
Creative Research Enterprises (United States)
2017
Atrium Medisch Centrum Parkstad
2012-2015
In Brief Objective: To determine the association of sarcopenia with postoperative morbidity and mortality after colorectal surgery. Background: Functional compromise in elderly surgical patients is considered as a significant factor impaired recovery. Therefore, predictive value preoperative functional assessment was investigated. Sarcopenia hallmark compromise. Methods: A total 310 consecutive who underwent oncologic surgery were included prospective digital database. assessed using L3...
BACKGROUND: Fifteen to twenty percent of patients with locally advanced rectal cancer have a clinical complete response after chemoradiation therapy. These can be offered nonoperative organ-preserving treatment, the so-called watch-and-wait policy. The main goal this policy is an anticipated improved quality life and functional outcome in comparison total mesorectal excision, while maintaining good oncological outcome. OBJECTIVE: aim study was compare matched-controlled group who underwent...
The oncological efficacy and safety of laparoscopic gastrectomy are under debate for the Western population with predominantly advanced gastric cancer undergoing multimodality treatment.In 10 experienced upper GI centers in Netherlands, patients resectable (cT1-4aN0-3bM0) adenocarcinoma were randomly assigned to either or open gastrectomy. No masking was performed. primary outcome hospital stay. Analyses performed by intention treat. It hypothesized that leads shorter stay, less...
Aim of this study was to assess the prevalence sarcopenia and body composition (i.e., subcutaneous visceral fat) in gastric cancer surgical patients its association with adverse postoperative outcome.Preoperative CT scans were obtained from all who underwent surgery for adenocarcinoma between January 2005 September 2012. Total muscle adipose tissue cross-sectional area measured at level third lumbar vertebra (L3) transverse processes. Sarcopenia defined according gender- mass index...
For gastric cancer patients, surgical resection with en-bloc lymphadenectomy is the cornerstone of curative treatment. Open gastrectomy has long been preferred approach worldwide. However, this procedure associated considerable morbidity. Several meta-analyses have shown an advantage in short-term outcomes laparoscopic compared to open procedures, similar oncologic outcomes. it remains unclear whether results these Asian studies can be extrapolated Western population. In trial from...
Rectal cancer surgery is accompanied with high morbidity and poor long term functional outcome. Screening programs have shown a shift towards more early staged cancers. Patients rectal can potentially benefit significantly from preserving therapy. For the earliest stage cancers, local excision sufficient when risk of lymph node disease subsequent recurrence below 5 %. However, majority cancers are associated an intermediate involvement (5-20 %) suggesting that alone not sufficient, while...
Centralization of surgery has been shown to improve outcomes for oesophageal and pancreatic cancer, implemented gastric cancer since 2012 in the Netherlands. This study evaluated impact centralizing on all patients with cancer.Patients diagnosed non-cardia adenocarcinoma intervals 2009-2011 2013-2015 were selected from Netherlands Cancer Registry. Clinicopathological data, treatment characteristics mortality assessed periods before (2009-2011) after (2013-2015) centralization. Cox regression...
<h3>Importance</h3> The optimal staging for gastric cancer remains a matter of debate. <h3>Objective</h3> To evaluate the value of<sup>18</sup>F-fludeoxyglucose–positron emission tomography with computed (FDG-PET/CT) and laparoscopy (SL) in addition to initial by means gastroscopy CT patients locally advanced cancer. <h3>Design, Setting, Participants</h3> This multicenter prospective, observational cohort study included 394 advanced, clinically curable adenocarcinoma (≥cT3 and/or N+, M0...
The use of lLaparoscopic liver resection in terms time to functional recovery, length hospital stay (LOS), long-term abdominal wall hernias, costs and quality life (QOL) has never been studied a randomised controlled trial. Therefore, this is the subject international multicentre ORANGE II Patients eligible for left lateral sectionectomy (LLS) will be recruited at outpatient clinic. All patients undergo surgery setting an ERAS programme. experimental design produces two arms (open...
<h2>Abstract</h2> <b>Objective:</b> Apoptosis, or programmed cell death, has been suggested as a mechanism of immunologic injury during cardiac allograft rejection. We tested the hypothesis that technetium Tc 99m annexin V, novel radiopharmaceutical used to detect apoptosis, can be rejection by nuclear imaging. <b>Methods:</b> Untreated ACI rats served recipients allogeneic PVG rat (n = 66) syngeneic 30) grafts. recipient animals underwent <sup>99m</sup>Tc-annexin V imaging daily for 7 days....
Emergency treatment for patients with a ruptured hepatocellular adenoma is controversial. The aim of this study was to evaluate management selective arterial embolization.The included 11 consecutive treated adenomas between 2001 and 2006. After initial haemodynamic support, all received embolization branches the hepatic artery. primary outcome effectiveness in stopping bleeding. Secondary outcomes were complications changes tumour size after embolization.A single brought haemorrhaging under...
Insight in health-related quality of life (HRQoL) may improve clinical decision making and inform patients about the long-term effects gastrectomy. This study aimed to evaluate identify factors associated with HRQoL after cross-sectional used prospective databases from seven Dutch centers (2001–2015) including who underwent gastrectomy for cancer. Between July 2015 November 2016, European Organization Research Treatment Cancer questionnaires QLQ-C30 QLQ-STO22 were sent all surviving without...
A small remnant liver volume is an important risk factor for posthepatectomy failure. ImageJ and OsiriX® are both free, open-source image processing software packages. The aim of the present study was to compare in performing prospective computed tomography (CT) volumetric analysis on a personal computer (PC) patients undergoing major resection.Patients scheduled right hemihepatectomy were eligible inclusion. Two surgeons one surgical trainee measured volumes total liver, tumor, future...
Functional compromise in elderly patients is considered to be a significant contributing factor increased postoperative morbidity and mortality. It described as state of reduced physiologic reserves including, e.g., sarcopenia, cachexia, malnutrition frailty with susceptibility adverse health outcomes. Aim this study was investigate the association sarcopenia mortality ICU patients.A retrospective analysis total 687 admitted from January 2013 until December 2014 performed. Indirect...
Distal gastrectomy (DG) for gastric cancer can cause less morbidity than total (TG), but may compromise radicality. No prospective studies administered neoadjuvant chemotherapy, and few assessed quality of life (QoL). The multicenter LOGICA-trial randomized laparoscopic versus open D2-gastrectomy resectable adenocarcinoma (cT1–4aN0–3bM0) in 10 Dutch hospitals. This secondary LOGICA-analysis compared surgical oncological outcomes after DG TG. was performed non-proximal tumors if R0-resection...