A5009303794- Intestinal Malrotation and Obstruction Disorders
- Congenital gastrointestinal and neural anomalies
- Infant Nutrition and Health
- Clinical Nutrition and Gastroenterology
- Hernia repair and management
- Colorectal Cancer Surgical Treatments
- Esophageal and GI Pathology
- Teratomas and Epidermoid Cysts
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
- Neonatal Respiratory Health Research
- Thyroid Cancer Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Appendicitis Diagnosis and Management
- Abdominal Surgery and Complications
- Tumors and Oncological Cases
- Abdominal vascular conditions and treatments
- Barrier Structure and Function Studies
- Enhanced Recovery After Surgery
- Intestinal and Peritoneal Adhesions
- Organ Transplantation Techniques and Outcomes
- Thyroid and Parathyroid Surgery
- Congenital Anomalies and Fetal Surgery
University of Amsterdam
2019-2025
Amsterdam University Medical Centers
2019-2025
Vrije Universiteit Amsterdam
2019-2025
Emma Kinderziekenhuis
2017-2025
Hersenstichting
2022
Maastricht University Medical Centre
2008-2021
Maastricht University
2010-2021
Amsterdam UMC Location Vrije Universiteit Amsterdam
2017-2019
Amsterdam UMC Location University of Amsterdam
2017-2018
University Medical Center
2008-2018
In Brief Objective: To determine the association of sarcopenia with postoperative morbidity and mortality after colorectal surgery. Background: Functional compromise in elderly surgical patients is considered as a significant factor impaired recovery. Therefore, predictive value preoperative functional assessment was investigated. Sarcopenia hallmark compromise. Methods: A total 310 consecutive who underwent oncologic surgery were included prospective digital database. assessed using L3...
To improve diagnosis of necrotizing enterocolitis (NEC) by noninvasive markers representing gut wall integrity loss (I-FABP and claudin-3) inflammation (calprotectin). Furthermore, the usefulness I-FABP to predict NEC severity screen for was evaluated.Urinary claudin-3 concentrations fecal calprotectin were measured in 35 consecutive neonates suspected at moment suspicion. investigate as screening tool NEC, daily urinary levels determined 6 who developed out 226 included before clinical...
This study aims at improving diagnosis of intestinal ischemia, by measuring plasma and urinary fatty acid binding protein (FABP) levels.Fifty consecutive patients suspected ischemia were included blood urine sampled time suspicion. Plasma concentrations FABP (I-FABP), liver (L-FABP) ileal bile (I-BABP) measured using enzyme-linked immunosorbent assays.Twenty-two diagnosed with 24 other diseases, 4 excluded from further analysis fulfilling exclusion criteria. Median I-FABP L-FABP all 3...
Aim of this study was to assess the prevalence sarcopenia and body composition (i.e., subcutaneous visceral fat) in gastric cancer surgical patients its association with adverse postoperative outcome.Preoperative CT scans were obtained from all who underwent surgery for adenocarcinoma between January 2005 September 2012. Total muscle adipose tissue cross-sectional area measured at level third lumbar vertebra (L3) transverse processes. Sarcopenia defined according gender- mass index...
Esophageal surgery is associated with complications and mortality. It highly important to develop tools predicting unfavorable postoperative outcome. cancer neoadjuvant chemoradiotherapy (CRT) induce skeletal muscle wasting, which leads diminished physiologic reserves. The purpose of this study was investigate whether the degree mass lost during CRT predicts mortality.A total 123 consecutive patients undergoing for esophageal malignancy in period 2008-2012 were included, whom 114 received...
Intestinal fatty acid-binding protein (I-FABP) is a useful marker in the detection of intestinal ischemia. However, more insight into test characteristics I-FABP release needed. This study aimed to investigate relationship between plasma levels and severity ischemic mucosal injury, define clinical usefulness systemic following ischemia.In human experimental model, 6 cm jejunum, be removed for surgical reasons, was selectively exposed either 15, 30, or 60 minutes ischemia (I) followed by 30...
The development of sepsis and multiple organ failure are important determinants the outcome in critically ill patients. Hepatosplanchnic hypoperfusion resulting intestinal hepatic cell damage have been implicated as central events failure. Our aim was to study (1) relation between intramucosal perfusion an early phase (2) correlation these parameters with mortality. Two groups patients were consecutively selected after intensive care unit admission: postoperative abdominal (n = 19)...
Background Intestinal ischemia-reperfusion (IR) is a phenomenon related to physiological conditions (e.g. exercise, stress) and pathophysiological events acute mesenteric ischemia, aortic surgery). Although intestinal IR has been studied extensively in animals, results remain inconclusive data on human are scarce. Therefore, an experimental harmless model for was developed, enabling us clarify the sequelae of first time. Methods Findings In 30 patients undergoing pancreatico-duodenectomy we...
Background and Goals In the clinical management of celiac disease, new noninvasive tools for evaluation intestinal damage are needed diagnosis follow-up diet effects. Fatty acid binding proteins (FABP) potentially useful this purpose as these small cytosolic present in enterocytes sensitive markers mucosal damage. First, distribution microscopic localization FABP healthy human intestine was examined. Second, levels circulating were measured patients with disease before after introducing a...
Liver failure following liver surgery is caused by an insufficient functioning remnant cell mass. This can be due to volume and aggravated additional death during or after surgery. The aim of this study was elucidate the causes hepatocellular injury in patients undergoing resection.Markers hepatocyte (AST, GSTalpha, L-FABP) inflammation (IL-6) were measured plasma resection with without intermittent inflow occlusion. To separate involvement intestines systemic L-FABP release, arteriovenous...
Chorioamnionitis is the most significant source of prenatal inflammation and preterm delivery. Prematurity are associated with compromised postnatal developmental outcomes, intestinal immune defence, gut barrier function vascular system. We developed a sheep model to study how antenatal development was affected by gestation and/or endotoxin induced chorioamnionitis.Chorioamnionitis at different gestational ages (GA). Animals were sacrificed low GA after 2d or 14d exposure chorioamnionitis....
The main objective of this study was to evaluate the diagnostic accuracy two novel biomarkers, calprotectin (CP) and serum amyloid A (SAA), along with more traditional inflammatory markers C-reactive protein (CRP) white blood cell count (WBC), in patients suspected having acute appendicitis (AA). secondary compare these biomarkers a clinical scoring system radiologic imaging. total 233 AA, presenting emergency department (ED) between January 2010 September 2010, 52 healthy individuals...
Anastomotic leakage (AL) remains the most dreaded complication after colorectal surgery and causes high morbidity mortality. The pathophysiology of AL unclear, despite numerous studies that have been conducted on animals humans, probably due to undetermined healing process anastomoses. Increasing basic knowledge this may shed more light causal factors AL, additionally reduce quantity accelerate quality experimental studies. In debate article, our aim was provide different perspectives what...
BACKGROUND Despite the emerging knowledge about colorectal anastomotic leakage (CAL) through increasing number of clinical and experimental studies, there is no generally accepted definition CAL. Because wide variety definitions used in literature, comparison study outcomes quality care complicated. AIM To reach consensus on CAL using a modified Delphi method. METHODS The RAND/UCLA appropriateness method was used. expert panel consisted international surgeons researchers who had published...