A5063516150- Hernia repair and management
- Colorectal Cancer Surgical Treatments
- Gastroesophageal reflux and treatments
- Bariatric Surgery and Outcomes
- Intestinal and Peritoneal Adhesions
- Esophageal and GI Pathology
- Abdominal Surgery and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Diet and metabolism studies
- Enhanced Recovery After Surgery
- Helicobacter pylori-related gastroenterology studies
- Adipose Tissue and Metabolism
- Colorectal Cancer Screening and Detection
- Surgical Sutures and Adhesives
- Pelvic and Acetabular Injuries
- Thyroid and Parathyroid Surgery
- Gastric Cancer Management and Outcomes
- Minimally Invasive Surgical Techniques
- Appendicitis Diagnosis and Management
- Gallbladder and Bile Duct Disorders
- Surgical Simulation and Training
- Esophageal Cancer Research and Treatment
- Advanced Chemical Sensor Technologies
- Intraperitoneal and Appendiceal Malignancies
- Eosinophilic Esophagitis
University Medical Center
2012-2025
Maastricht University
2016-2025
Maastricht University Medical Centre
2016-2025
HealthPartners
2024
Yahoo (United Kingdom)
2023
Nordic Pharma (France)
2023
National Health Service
2023
Amsterdam University Medical Centers
2023
Leiden University Medical Center
2020
Erasmus MC
2002-2020
Studies in animals indicate that brown adipose tissue is important the regulation of body weight, and it possible individual variation adaptive thermogenesis can be attributed to variations amount or activity tissue. Until recently, presence was thought relevant only small mammals infants, with negligible physiologic relevance adult humans. We performed a systematic examination presence, distribution, lean obese men during exposure cold temperature. Brown-adipose-tissue studied relation...
Surgery for obesity and metabolic diseases has been evolved in the light of new scientific evidence, long-term outcomes accumulated experience. EAES sponsored an update previous guidelines on bariatric surgery.A multidisciplinary group surgeons, physicians, nutritional experts, psychologists, anesthetists a patient representative comprised guideline development panel. Development reporting conformed to GRADE AGREE II standards.Systematic review databases, record selection, data extraction...
Background Cold-stimulated adaptive thermogenesis in brown adipose tissue (BAT) to increase energy expenditure is suggested as a possible therapeutic target for the treatment of obesity. We have recently shown high prevalence BAT adult humans, which was inversely related body mass index (BMI) and fat percentage (BF%), suggesting that obesity associated with lower activity. Here, we examined activity morbidly obese subjects its role cold-induced (CIT) after applying personalized cooling...
The endoscopically placed duodenal-jejunal bypass sleeve or EndoBarrier Gastrointestinal Liner has been designed to achieve weight loss in morbidly obese patients. We report on the first European experience with this device.A multicenter, randomized clinical trial was performed. Forty-one patients were included and 30 underwent implantation. Eleven served as a diet control group. All followed same low-calorie during study period. purpose of determine safety efficacy device.Twenty-six devices...
Acute diverticulitis (AD) presents a unique diagnostic and therapeutic challenge for general surgeons. This collaborative project between EAES SAGES aimed to summarize recent evidence draw statements of recommendation guide our members on comprehensive AD management. Systematic reviews the literature were conducted across six topics by an international steering group including experts from both societies. Topics encompassed epidemiology, diagnosis, management non-complicated complicated as...
A tumor model in the rat was used to study peritoneal growth and abdominal wall metastases after carbon dioxide (CO2) pneumoperitoneum, gasless laparoscopy, laparotomy.The role of laparoscopic resection cancer is under debate. Insufflation cavity with CO2 believed be a causative factor development malignant tumors.In solid model, lump 350-mg CC-531 cells placed intraperitoneally rats having pneumoperitoneum (n = 8), laparoscopy or conventional laparotomy 8). After 20 minutes, removed through...
Stimulation of thermogenesis in brown adipose tissue (BAT) is a potential target to treat obesity. We earlier demonstrated that BAT activity relatively low obese subjects. It unknown whether can be recruited adult humans. To study the dynamics BAT, we observed morbidly subjects before and after weight loss induced by bariatric surgery. This was an observational prospective cohort study. The conducted at referral center. Ten eligible for laparoscopic adjustable gastric banding surgery were...
In Brief Objective: Investigate the safety and efficacy of 6 months' duodenal-jejunal bypass liner (DJBL) treatment in comparison with dietary intervention for obesity type 2 diabetes mellitus (T2DM). Background: The DJBL is a bariatric procedure involving an impermeable sleeve that delivered endoscopically proximal intestine. This not only less invasive than conventional surgical techniques but also has beneficial effects on T2DM. Methods: A multicenter randomized controlled trial was...
In laparoscopic ventral hernia repair a mesh is placed in direct contact with the viscera, often leading to substantial adhesions. this experimental study ability of different coated and uncoated meshes attenuate adhesion formation was examined.Six commercially available were intraperitoneally against closed peritoneum rats: Prolene (polypropylene), Timesh Ultrapro (polypropylene composites titanium polyglecaprone respectively), Proceed Parietex Composite polyester layer cellulose collagen...
Objectives: Transoral incisionless fundoplication (TIF) was developed in an attempt to create a minimally invasive endoscopic procedure that mimics antireflux surgery. The objective of this trial evaluate effectiveness TIF compared with proton pump inhibition population consisting gastroesophageal reflux disease (GERD) patients controlled inhibitors (PPIs) who opted for intervention over lifelong drug dependence. Methods: Patients chronic GERD were randomized (2:1) or continuation PPI...
In addition to biochemical cure, clinical benefits after surgery for primary aldosteronism depend on the magnitude of decrease in blood pressure (BP) and use antihypertensive medications with a subsequent decreased risk cardiovascular and/or cerebrovascular morbidity drug-induced adverse effects.To evaluate change BP within an international cohort patients who recently underwent aldosteronism.A study was conducted across 16 referral medical centers Europe, United States, Canada, Australia....
Although self-expandable metal stent (SEMS) placement as bridge to surgery (BTS) in patients with left-sided obstructing colonic cancer has shown promising short-term results, it is used infrequently owing uncertainty about its oncological safety. This population study compared long-term outcomes between emergency resection and SEMS BTS.Through a national collaborative research project, outcome data were collected for all who underwent 2009 2016 75 Dutch hospitals. Patients identified from...
Abstract Background As the population ages, more older adults are presenting for surgery. Age-related declines in physiological reserve and functional capacity can result frailty poor outcomes after Hence, optimizing perioperative care patients is imperative. Enhanced Recovery After Surgery (ERAS) pathways Minimally Invasive (MIS) may influence surgical outcomes, but current use impact on unknown. The aim of this study was to provide evidence-based recommendations undergoing major abdominal...