H.J.T. Rutten
A5080105484- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Anorectal Disease Treatments and Outcomes
- Genetic factors in colorectal cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Breast Cancer Treatment Studies
- Intraperitoneal and Appendiceal Malignancies
- Radiomics and Machine Learning in Medical Imaging
- Breast Lesions and Carcinomas
- Enhanced Recovery After Surgery
- Stoma care and complications
- Hernia repair and management
- Appendicitis Diagnosis and Management
- Clinical practice guidelines implementation
- Nutrition and Health in Aging
- Breast Implant and Reconstruction
- Frailty in Older Adults
- Esophageal Cancer Research and Treatment
- Advanced Radiotherapy Techniques
- Pelvic floor disorders treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Ovarian cancer diagnosis and treatment
Radboud University Nijmegen
2016-2025
Maastricht University
2016-2025
Catharina Ziekenhuis
2016-2025
Amsterdam University Medical Centers
2024
University of Amsterdam
2024
Cancer Center Amsterdam
2024
Southampton General Hospital
2023
University of Southampton
2023
PAMM
2021
Leiden University Medical Center
2004-2020
Short-term preoperative radiotherapy and total mesorectal excision have each been shown to improve local control of disease in patients with resectable rectal cancer. We conducted a multicenter, randomized trial determine whether the addition increases benefit excision.We randomly assigned 1861 cancer either (5 Gy on five days) followed by (924 patients) or alone (937 patients). The was use standardization quality-control measures ensure consistency radiotherapy, surgery, pathological...
In Brief Objective: To investigate the efficacy of preoperative short-term radiotherapy in patients with mobile rectal cancer undergoing total mesorectal excision (TME) surgery. Summary Background Data: Local recurrence is a major problem treatment. Preoperative has shown to improve local control and survival combination conventional The TME trial investigated value this regimen excision. Long-term results are reported after median follow-up 6 years. Methods: One thousand eight hundred...
Preoperative short-term radiotherapy improves local control in patients treated with total mesorectal excision (TME). This study was performed to assess the presence and magnitude of long-term side effects preoperative 5 x Gy TME. Also, hospital treatment recorded for diseases possibly related late rectal cancer treatment.Long-term morbidity assessed from prospective randomized TME trial, which investigated efficacy before surgery mobile cancer. Dutch without recurrent disease were sent a...
Abstract Background Anastomotic leakage is a major complication of rectal cancer surgery. The aim this study was to investigate risk factors associated with symptomatic anastomotic after total mesorectal excision (TME). Methods Between 1996 and 1999, patients operable were randomized receive short-term radiotherapy followed by TME or undergo alone. Eligible Dutch who underwent an anterior resection (924 patients) studied retrospectively. Results Symptomatic occurred in 107 (11·6 per cent)....
Few prospective studies have been performed about the impact of preoperative radiotherapy (PRT) or total mesorectal excision (TME) on health-related quality life (HRQL) and sexual functioning in patients with resectable rectal cancer. This report describes HRQL 990 who underwent TME were randomly assigned to short-term PRT (5 x 5 Gy).The Rotterdam Symptom Check List supplemented additional items was used questionnaires before treatment at 3, 6, 12, 18, 24 months after surgery. Patients...
Improvements in magnetic resonance imaging (MRI), total mesorectal excision (TME) surgery, and the use of (chemo)radiotherapy ([C]RT) have improved local control rectal cancer; however, we been unable to eradicate recurrence (LR). Even face TME negative resection margins (R0), a significant proportion patients with enlarged lateral lymph nodes (LLNs) suffer from LR (LLR). Japanese studies suggest that addition an LLN dissection (LLND) could reduce LLR. This multicenter pooled analysis aims...
The aim of our study was to provide population-based data on incidence and prognosis synchronous peritoneal carcinomatosis evaluate predictors for its development. Diagnosed in 1995-2008, 18,738 cases primary colorectal cancer were included. Predictors analysed by multivariable logistic regression analysis. Median survival months calculated site metastasis. In the period, 904 patients diagnosed with (4.8% total, constituting 24% presenting M1 disease). risk increased case advanced T stage...
Consensus abstract Background The management of primary rectal cancer beyond total mesorectal excision planes (PRC-bTME) and recurrent (RRC) is challenging. There global variation in standards no guidelines exist. To achieve cure most patients require extended, multivisceral, exenterative surgery, conventional planes. aim the Beyond TME Group was to consensus on definitions principles management, identify areas research priority. Methods Delphi methodology used consensus. consisted invited...
Previously, it was shown in patients with low rectal cancer that a short-axis (SA) lateral node size of 7 mm or greater on primary magnetic resonance imaging (MRI) resulted high local recurrence (LLR) rate after chemoradiotherapy radiotherapy ([C]RT) total mesorectal excision (TME) and this risk lowered by lymph dissection (LLND). The role restaging MRI (C)RT regard to LLR which specific might benefit from an LLND is not fully understood.To determine the factors are associated formulate...
Consensus abstract Background The management of primary rectal cancer beyond total mesorectal excision planes (PRC-bTME) and recurrent (RRC) is challenging. There global variation in standards no guidelines exist. To achieve cure most patients require extended, multivisceral, exenterative surgery, conventional planes. aim the Beyond TME Group was to consensus on definitions principles management, identify areas research priority. Methods Delphi methodology used consensus. consisted invited...
Abstract Background This prospective multicentre study was performed to quantify the number of patients with minimal residual disease (ypT0–1) after neoadjuvant chemoradiotherapy and transanal endoscopic microsurgery (TEM) for rectal cancer. Methods Patients clinically staged T1–3 N0 distal cancer were treated long-course chemoradiotherapy. Clinical response evaluated 6–8 weeks later TEM performed. Total mesorectal excision advocated in (ypT2 or more). Results The clinical stage cT1 ten...
Abstract Background Pelvic exenteration for locally recurrent rectal cancer (LRRC) is associated with variable outcomes, the majority of data from single-centre series. This study analysed an international collaboration to determine robust parameters that could inform clinical decision-making. Methods Anonymized on patients who had pelvic LRRC between 2004 and 2014 were accrued 27 specialist centres. The primary endpoint was survival. impact resection margin, bone resection, node status use...