A5062782199- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Multiple and Secondary Primary Cancers
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Helicobacter pylori-related gastroenterology studies
- Diverticular Disease and Complications
- Gastrointestinal disorders and treatments
- Esophageal Cancer Research and Treatment
- Global Cancer Incidence and Screening
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Economic and Financial Impacts of Cancer
- Gastrointestinal Bleeding Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Mycobacterium research and diagnosis
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Cancer, Lipids, and Metabolism
- Lymphoma Diagnosis and Treatment
The Netherlands Cancer Institute
2016-2025
Leiden University Medical Center
2019-2025
Oncode Institute
2019-2025
Leiden University
2020-2024
Molecular Oncology (United States)
2024
Dutch Cancer Society
2023
Erasmus MC
2009-2022
Netherlands Consortium for Healthy Ageing
2019
RELX Group (Netherlands)
2018
Amsterdam UMC Location University of Amsterdam
2000-2017
There is a clear and unmet clinical need for biomarkers to predict responsiveness chemotherapy cancer. We developed an in vitro test based on patient-derived tumor organoids (PDOs) from metastatic lesions identify nonresponders standard-of-care colorectal cancer (CRC). In prospective study, we show the feasibility of generating testing PDOs evaluation sensitivity chemotherapy. Our PDO predicted response biopsied lesion more than 80% patients treated with irinotecan-based therapies without...
The aim of this study was to examine recent time trends in incidence and outcome upper GI bleeding.Prospective data collection on all patients presenting with acute bleeding from a defined geographical area the period 1993/1994 2000.Incidence decreased 61.7/100,000 1993/94 47.7/100,000 persons annually 2000, corresponding 23% decrease after age adjustment (95% CI = 15-30%). higher among more advanced age. Rebleeding (16% vs 15%) mortality (14% 13%) did not differ between two periods. Ulcer...
<h3>Background:</h3> Screening for colorectal cancer (CRC) is widely accepted, but there no consensus on the preferred strategy. We conducted a randomised trial comparing participation and detection rates (DR) per screenee of guaiac-based faecal occult blood test (gFOBT), immunochemical FOBT (FIT), flexible sigmoidoscopy (FS) CRC screening. <h3>Methods:</h3> A representative sample Dutch population (n = 15 011), aged 50–74 years, was 1:1:1 prior to invitation one three screening strategies....
Immunochemical faecal occult blood testing (FIT) provides quantitative test results, which allows optimisation of the cut-off value for follow-up colonoscopy. We conducted a randomised population-based trial to determine characteristics FIT (OC-Sensor micro, Eiken, Japan) screening at different levels and compare these with guaiac-based (gFOBT) in an average risk population. A representative sample Dutch population (n=10 011), aged 50–74 years, was 1 : before invitation gFOBT screening....
<h3>Objective</h3> Accurate endoscopic differentiation would enable to resect and discard small diminutive colonic lesions, thereby increasing cost-efficiency. Current classification systems based on narrow band imaging (NBI), however, do not include neoplastic sessile serrated adenomas/polyps (SSA/Ps). We aimed develop validate a new system for of adenomas, hyperplastic polyps SSA/Ps <10 mm. <h3>Design</h3> developed the Workgroup serrAted polypS Polyposis (WASP) classification,...
Main Recommendations ESGE recommends that individuals with hereditary gastrointestinal polyposis syndromes should be surveilled in dedicated units provide monitoring of compliance and endoscopic performance measures. Strong recommendation, moderate quality evidence, level agreement 90 %. performing esophagogastroduodenoscopy, small-bowel examination, and/or colonoscopy earlier than the planned surveillance procedure if a patient is symptomatic. low 100
Mismatch repair-deficient (dMMR) tumors can be found in 10 to 15% of patients with nonmetastatic colon cancer. In these patients, the efficacy chemotherapy is limited. The use neoadjuvant immunotherapy has shown promising results, but data from studies this approach are
Abstract Gastric and gastroesophageal junction (G/GEJ) cancers carry a poor prognosis, despite recent advancements, most patients die of their disease. Although immune checkpoint blockade became part the standard-of-care for with metastatic G/GEJ cancers, its efficacy impact on tumor microenvironment (TME) in early disease remain largely unknown. We hypothesized higher neoadjuvant immunotherapy plus chemotherapy nonmetastatic cancer. In phase 2 PANDA trial, previously untreated resectable...
Importance A watch-and-wait approach for patients with rectal cancer and a clinical complete response after neoadjuvant chemoradiotherapy or radiotherapy is associated better quality of life functional outcome. Nevertheless, prospective data on both parameters are scarce. Objective To prospectively evaluate outcome, including bowel, urinary, sexual function, following approach. Design, Setting, Participants total 278 near-complete were included in 2 cohort studies: single-center study (March...
<h3>Background and aims</h3> Patients with hyperplastic polyposis syndrome (HPS) receive endoscopic surveillance to prevent malignant progression of polyps. However, the optimal treatment protocol for these patients is unknown. The aim this study was describe clinical pathological features a large HPS cohort during multiple years surveillance. <h3>Methods</h3> Databases were searched HPS, who analysed retrospectively. Endoscopy reports histopathology collected evaluate frequency obtain...
<h3>Background</h3> Peutz–Jeghers syndrome (PJS) is associated with an increased cancer risk. As the determination of optimal surveillance strategies hampered by wide ranges in risk estimates and lack data on cancer-related mortality, we assessed risks mortality a large cohort patients PJS. <h3>Methods</h3> Dutch PJS were included this study. Patients followed prospectively between January 1995 July 2009, clinical from period before collected retrospectively. Data obtained interview chart...
Fecal immunochemical testing (FIT) is increasingly used for colorectal cancer (CRC) screening. We aimed to estimate its diagnostic accuracy in invitational population screening measured against colonoscopy.Participants (50-75 years) an primary colonoscopy program were asked complete one sample FIT before colonoscopy. estimated sensitivity, specificity, and predictive values detecting CRC advanced neoplasia (carcinomas adenomas) cutoff levels of 50 (FIT50), 75 (FIT75), 100 (FIT100) ng...
Peutz-Jeghers syndrome (PJS) is characterized by gastrointestinal hamartomas. The hamartomas are located predominantly in the small intestine and may cause intussusceptions. We aimed to assess characteristics, risk, onset of intussusception a large cohort PJS patients determine whether enteroscopy with polypectomy should be incorporated into surveillance recommendations.All from two academic hospitals were included this study (prospective follow-up between 1995 July 2009). obtained clinical...
<b>Background and study aim:</b> While colonoscopy screening is widely used in several European countries the United States, there are no randomized trials to quantify its benefits. The Nordic-European Initiative on Colorectal Cancer (NordICC) a multinational, controlled trial aiming at investigating effect of colorectal cancer (CRC) incidence mortality. This paper describes rationale design NordICC trial. <b>Study design:</b> Men women aged 55 64 years drawn from population registries...