A5087173002- Pregnancy and preeclampsia studies
- Breast Implant and Reconstruction
- Reconstructive Surgery and Microvascular Techniques
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Birth, Development, and Health
- Pelvic floor disorders treatments
- Anesthesia and Pain Management
- Breast Cancer Treatment Studies
- Cardiovascular Issues in Pregnancy
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Pain Mechanisms and Treatments
- Maternal and fetal healthcare
- Anorectal Disease Treatments and Outcomes
- Sepsis Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Pain Management and Opioid Use
- Pelvic and Acetabular Injuries
- Maternal and Perinatal Health Interventions
- Pregnancy-related medical research
- Frailty in Older Adults
- Atrial Fibrillation Management and Outcomes
- Pain Management and Treatment
Maastricht University Medical Centre
2016-2025
Maastricht University
2016-2025
University Medical Center
2016-2025
University Hospital and Clinics
2020-2025
Ente Ospedaliero Cantonale
2022-2024
University Hospital of Bern
2024
Máxima Medisch Centrum
2019-2024
Radboud University Nijmegen
2011-2024
Laboratory for Biomedical Neurosciences
2022-2024
Cardiovascular Institute Hospital
2024
Managing traumatic brain injury (TBI) patients with a cerebral perfusion pressure (CPP) near to the autoregulation (CA)-guided "optimal" CPP (CPPopt) value is associated improved outcome and might be useful individualize care, but has never been prospectively evaluated. This study evaluated feasibility safety of CA-guided management in TBI requiring intracranial monitoring therapy (TBIicp patients). The CPPopt Guided Therapy: Assessment Target Effectiveness (COGiTATE) parallel two-arm trial...
Importance A watch-and-wait approach for patients with rectal cancer and a clinical complete response after neoadjuvant chemoradiotherapy or radiotherapy is associated better quality of life functional outcome. Nevertheless, prospective data on both parameters are scarce. Objective To prospectively evaluate outcome, including bowel, urinary, sexual function, following approach. Design, Setting, Participants total 278 near-complete were included in 2 cohort studies: single-center study (March...
Although catheter ablation (CA) is successful for the treatment of paroxysmal atrial fibrillation (AF), results are less satisfactory in persistent AF. Hybrid (HA) better outcomes patients with (persAF), as it combines a thoracoscopic epicardial and transvenous endocardial approach single procedure.The purpose this study was to compare effectiveness safety HA CA prospective, superiority, unblinded, randomized controlled trial.Forty-one ablation-naive (long-standing)-persAF were (n = 19) or...
Background— Medical treatment of initially uncomplicated acute Stanford type-B aortic dissection is associated with a high rate late adverse events. Identification individuals who potentially benefit from preventive endografting highly desirable. Methods and Results— The association computed tomography imaging features events was retrospectively assessed in 83 patients dissection, followed over median 850 (interquartile range 247–1824) days. Adverse were defined as fatal or nonfatal rupture,...
OBJECTIVE Evidence from prospective studies for long-term treatment efficacy of spinal cord stimulation (SCS) in painful diabetic peripheral neuropathy (PDPN) is not available. We report data on the effect SCS pain ratings, success and failure, complications during a 5-year follow-up patients with PDPN. RESEARCH DESIGN AND METHODS Patients PDPN (n = 48) were included this multicenter study. The Michigan Diabetic Neuropathy Score (MDNS) was used to assess severity neuropathy. Numerical rating...
Nurse-led integrated care is expected to improve outcome of patients with atrial fibrillation compared usual-care provided by a medical specialist.We randomized 1375 (64 ± 10 years, 44% women, 57% had CHA2DS2-VASc ≥ 2) receive nurse-led or usual-care. was specialized nurses using decision-support tool, in consultation the cardiologist. The primary endpoint composite cardiovascular death and hospital admissions. Of 671 patients, 543 (81%) received anticoagulation full accordance guidelines...
The number of breast cancer survivors continues to grow. Due refinements in operating techniques, autologous reconstruction has become part standard care. Impaired sensation remains a debilitating side effect with significant impact on the quality life. Microsurgical nerve coaptation sensory potential improve reconstructed breast. This study investigates improved life survivors.A retrospective cohort was performed Maastricht University Medical Center. Patients undergoing DIEP flap between...
<h3>Objective</h3> This is the first double-blind randomized controlled trial evaluating efficacy and safety of IV immunoglobulin (IVIG) vs placebo in patients with idiopathic small fiber neuropathy (I-SFN). <h3>Methods</h3> Between July 2016 November 2018, 60 Dutch skin biopsy–proven I-SFN randomly received a starting dose IVIG (2 g/kg body weight) or matching (0.9% saline). Subsequently, 3 additional infusions (1 g/kg) were administered at 3-week intervals. The primary outcome was 1-point...
Surgical fear is present in many patients awaiting surgery. However, a validated Italian version of the Fear Questionnaire (SFQ) was not available yet. Therefore, aim this study to translate SFQ into and test its reliability validity. Design: prospective cohort on Italian-speaking Swiss scheduled for minimally invasive spinal procedure or After forward back translation pilot test, validity 8-item assessed using intraclass correlation coefficient, (ICC), Cronbach's alpha, confirmatory factor...
Abstract OBJECTIVES Previous analyses of the volume-outcome relationship have focused on short-term outcomes such as early mortality. The current study aims to update a novel statistical methodology, facilitating evaluation relation between procedural volume and time-to-event long-term survival, using surgery for acute type A aortic dissection an illustrative example. METHODS This employed existing dataset outcomes, retrieved from literature. Studies were included when reporting annual case...
BACKGROUND: Risk stratification is highly desirable in patients with uncomplicated Stanford type B aortic dissection but inadequately supported by evidence. We sought to validate externally a published prediction model for late adverse events (LAEs), consisting of 1 clinical (connective tissue disease) and 4 imaging variables: maximum diameter, false lumen circumferential angle, outflow, number identifiable intercostal arteries. METHODS: assembled retrospective multicenter cohort (ROADMAP...
Background and purposeCarbonic anhydrase IX (CAIX) plays an important role in pH regulation processes critical for tumor cell growth metastasis. We hypothesize that a dual targeting bioreductive nitroimidazole based anti-CAIX sulfamide drug (DH348) will reduce sensitize tumors to irradiation CAIX dependent manner.Material methodsThe effect of the its single control drugs on extracellular acidification radiosensitivity was examined HT-29 colorectal carcinoma cells. Tumor time reach 4× start...