A5054134106- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Peripheral Neuropathies and Disorders
- Ion channel regulation and function
- Hereditary Neurological Disorders
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Epilepsy research and treatment
- Esophageal Cancer Research and Treatment
- Ion Channels and Receptors
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac electrophysiology and arrhythmias
- Neurology and Historical Studies
- Cutaneous Melanoma Detection and Management
- Statistical Methods in Clinical Trials
- Effects of Vibration on Health
- Endometriosis Research and Treatment
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- MRI in cancer diagnosis
- Stroke Rehabilitation and Recovery
- Fungal and yeast genetics research
- Sympathectomy and Hyperhidrosis Treatments
- Cellular transport and secretion
Philips (Netherlands)
2025
Maastricht University Medical Centre
2015-2023
Maastricht University
2014-2022
Adelante
2021
University Medical Center
2014-2020
Symptomatic treatment of neuropathic pain in small fibre neuropathy is often disappointing. The finding voltage-gated sodium channel mutations (with SCN9A, encoding for Nav1.7) being most frequently reported suggest a specific target therapy. anticonvulsant lacosamide acts on Nav1.3, Nav1.7, and Nav1.8. aim this study was to evaluate the efficacy, safety, tolerability as potential Nav1.7-related neuropathy. Lacosamide-Efficacy-'N'-Safety SFN (LENSS) randomized, placebo-controlled,...
<h3>Objective</h3> This is the first double-blind randomized controlled trial evaluating efficacy and safety of IV immunoglobulin (IVIG) vs placebo in patients with idiopathic small fiber neuropathy (I-SFN). <h3>Methods</h3> Between July 2016 November 2018, 60 Dutch skin biopsy–proven I-SFN randomly received a starting dose IVIG (2 g/kg body weight) or matching (0.9% saline). Subsequently, 3 additional infusions (1 g/kg) were administered at 3-week intervals. The primary outcome was 1-point...
Background Neuropathic pain is common in peripheral neuropathy. Recent genetic studies have linked pathogenic voltage-gated sodium channel (VGSC) variants to human disorders. Our aims are determine the frequency of SCN9A , SCN10A and SCN11A patients with pure small fibre neuropathy (SFN), analyse their clinical features provide a rationale for screening. Methods Between September 2009 January 2017, 1139 diagnosed SFN at our reference centre were screened variants. Pathogenicity was...
Endometriosis is a benign gynecological disease with high burden and significant, multifaceted impact on health-related quality of life (HRQoL) sexual (SQoL).To explore which patient- disease-specific characteristics were independently associated SQoL.A literature search was carried out to identify an evidence-based or hypothesized effect SQoL. Subsequently, data HRQoL in women endometriosis (n = 224), collected between 2013 2018 prospective longitudinal Dutch cohort study performed 7...
Abstract Small fibre neuropathy is a common pain disorder, which in many cases fails to respond treatment with existing medications. Gain-of-function mutations of voltage-gated sodium channel Nav1.7 underlie dorsal root ganglion neuronal hyperexcitability and subset patients small neuropathy. Recent clinical studies have demonstrated that lacosamide, blocks channels use-dependent manner, attenuates some mutations; however, only subgroup these responded the drug. Here, we used voltage-clamp...
Determination of disease onset in Huntington's is made by clinical experience. The diagnostic confidence level an assessment regarding the certainty about diagnosis based on motor signs. A 4 means rater has ≥99% abnormalities are unequivocal signs disease. However, it does not state which and how many must be present.Our aim to explore accurate estimating using Enroll-HD data set. For we use a cut-off total score >5 Unified Disease Rating Scale. This used TRACK-HD study, with ≤5 indicating...
Objective Out-of-hospital cardiac arrest (OHCA) is a major public health challenge across Europe, with survival rate of only 8.5% to hospital discharge. Implementing community first responder (CFR) system, including earlier Basic Life Support and defibrillation, can enhance rates neurological outcomes. This study assesses the cost-effectiveness two scenarios for implementing such system in Belgium. Methods A decision tree long-term Markov model were used evaluate by comparing current care...
Objective Screening for Fabry disease in patients with small fiber neuropathy has been suggested, especially since is potentially treatable. However, the diagnostic yield of testing isolated never systematically investigated. Our aim to determine presence neuropathy. Methods Patients referred our institute, who met criteria were tested by measurement alpha-Galactosidase A activity blood, lysosomal globotriaosylsphingosine urine and analysis on possible GLA gene mutations. Results 725...
Neuropathic pain is a frequent feature of diabetic peripheral neuropathy (DPN) and small fiber (SFN). Resolving the genetic architecture these painful neuropathies will lead to better disease management strategies, counselling intervention. Our aims were profile ten sodium channel genes (SCG) expressed in nociceptive pathway painless DPN SFN patients, provide perspective for clinicians who assess patients with neuropathy. Between June 2014 September 2016, 1125 painful-DPN (n = 237),...
Small fiber neuropathy is the most common cause of neuropathic pain in peripheral neuropathies, with a minimum prevalence 53/100,000. Patients experience excruciating pain, and currently available anti-neuropathic other drugs do not relieve substantially. Several open-label studies have suggested an immunological basis small reported efficacy treatment intravenous immunoglobulin. Therefore, mechanisms conceivably may play role neuropathy. To date, no randomized controlled study...
Neuropathic pain is common in diabetic peripheral neuropathy (DN), probably caused by pathogenic ion channel gene variants. Therefore, we performed molecular inversion probes-next generation sequencing of 5 transient receptor potential cation channels, 8 potassium channels and 2 calcium-activated chloride genes 222 painful- 304 painless-DN patients. Twelve painful-DN (5.4%) patients showed potentially variants (five nonsense/frameshift, seven missense, one out-of-frame deletion) ANO3 (n =...
Neuropathic pain is a characteristic feature of small fiber neuropathy (SFN), which in 18% the cases caused by genetic variants voltage-gated sodium ion channels. In this study, we assessed role fifteen other channels neuropathic pain. Patients with SFN (n = 414) were analyzed for ANO1, ANO3, HCN1, KCNA2, KCNA4, KCNK18, KCNN1, KCNQ3, KCNQ5, KCNS1, TRPA1, TRPM8, TRPV1, TRPV3 and TRPV4 single-molecule molecular inversion probes-next-generation sequencing. These patients did not have SCN3A,...
<b><i>Background:</i></b> Though obesity is a well-known risk factor for vascular disease, the impact of on stroke outcome has been disputed. Several studies have shown that associated with better functional after stroke. Whether influences benefit endovascular treatment (EVT) in patients unknown. We evaluated association between body mass index (BMI) and acute ischemic large vessel occlusion (LVO), assessed whether BMI affects benefit EVT....
The aim of this study was to determine electrocardiographic (ECG) criteria predicting abnormal infrahissian conduction in patients with myotonic dystrophy type 1 (DM1), as these could be used identify the need for an electrophysiological (EPS).A retrospective multicentre conducted including DM1-affected individuals who underwent EPS between 2007 and 2018. For each individual, indication, His-ventricle (HV) interval, resting ECG parameters prior EPS, left ventricular ejection fraction (LVEF),...
Microelectrode recordings (MER) are used to optimize lead placement during subthalamic nucleus deep brain stimulation (STN-DBS). To obtain reliable MER, surgery is usually performed while patients awake. Procedural sedation and analgesia (PSA) often desirable improve patient comfort, anxiolysis pain relief. The effect of these agents on MER largely unknown. objective this study was determine the effects commonly PSA agents, dexmedetomidine, clonidine remifentanil characteristics DBS...
Small fiber neuropathy generally leads to considerable pain and autonomic symptoms. Gain-of-function mutations in the SCN9A- gene, which codes for Nav1.7 voltage-gated sodium channel, have been reported small neuropathy, suggesting an underlying genetic basis a subset of patients. Currently available channel blockers lack selectivity, leading cardiac central nervous system side effects. Lacosamide is anticonvulsant, blocks Nav1.3, Nav1.7, Nav1.8, stabilizes channels slow-inactivation state....
Background: Proximal esophageal cancer (EC) is commonly treated with definitive chemoradiation (CRT). The radiation dose and type of chemotherapy backbone are still under debate. objective this study was to compare the treatment outcomes contemporary CRT regimens.Material Methods: In retrospective observational cohort study, we included patients locally advanced squamous cell proximal esophagus, from 11 centers in Netherlands, between 2004 2014. Each center had a preferential regimen, based...
Success rates with conventional transvenous endocardial pulmonary vein isolation in patients persistent and longstanding atrial fibrillation (AF) are variable due to advanced electrical structural remodeling of the atria. As a consequence, more extensive lesions, minimally invasive thoracoscopic surgical techniques, hybrid ablation (combining epicardial catheter ablation) have been developed. The HARTCAP-AF trial hypothesizes that AF is effective than (repeated) (longstanding) AF, without...