A5016545357- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Cardiac and Coronary Surgery Techniques
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Lung Cancer Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Aortic aneurysm repair treatments
- Cardiac Ischemia and Reperfusion
- Acute Myocardial Infarction Research
- Cardiovascular Effects of Exercise
- Coronary Interventions and Diagnostics
- Pectus Deformity Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Hemodynamic Monitoring and Therapy
- Cardiac Health and Mental Health
Maastricht University
2016-2025
Maastricht University Medical Centre
2016-2025
University Medical Center
2013-2024
Hersenstichting
2024
Netherlands Heart Registration
2022-2024
Cardiovascular Institute Hospital
1995-2023
Maastro Clinic
2021
Nicolaus Copernicus University
2020
NorthEast Regional Epilepsy Group
2018
Narayana Health
2018
Inflammatory mechanisms have been proposed to be important in heart failure (HF), and cytokines implicated add the progression of HF. However, it is unclear whether such are already activated when hypertrophied hearts still appear well-compensated early contribute development HF.In a comprehensive microarray study, galectin-3 emerged as most robustly overexpressed gene failing versus functionally compensated from homozygous transgenic TGRmRen2-27 (Ren-2) rats. Myocardial biopsies obtained at...
The myocardium of the failing heart undergoes a number structural alterations, most notably hypertrophy cardiac myocytes and an increase in extracellular matrix proteins, often seen as primary fibrosis. Connective tissue growth factor (CTGF) is key molecule process fibrosis therefore seems attractive therapeutic target. Regulation CTGF expression at promoter level has been studied extensively, but it unknown how transcripts are regulated posttranscriptional level. Here we provide several...
Extracorporeal cardiopulmonary resuscitation (CPR) restores perfusion and oxygenation in a patient who does not have spontaneous circulation. The evidence with regard to the effect of extracorporeal CPR on survival favorable neurologic outcome refractory out-of-hospital cardiac arrest is inconclusive.
Transcatheter aortic valve implantation (TAVI) is a novel therapy for treatment of severe stenosis. Although 30% to 50% patients develop new left bundle-branch block (LBBB), its effect on clinical outcome unclear.Data were collected in multicenter registry encompassing TAVI from 2005 until 2010. The all-cause mortality rate at follow-up was compared between who did and not LBBB. Of 679 analyzed, 387 (57.0%) underwent with the Medtronic CoreValve System 292 (43.0%) Edwards SAPIEN valve. A...
To elucidate the epidemiology, complication profiles, hospital outcome, and predisposing factors of CNS complications occurring during venoarterial extracorporeal membrane oxygenation in adults.Retrospective analysis Extracorporeal Life Support Organization registry.Data reported to by 230 centers from 1992 2013.Patients more than 16 years old supported with a single-run oxygenation.None.We examined 4,522 adult patients included registry. Venoarterial was used for cardiac dysfunction 3,005...
Background Myoglobin and fatty acid–binding protein (FABP) each are useful as early biochemical markers of muscle injury. We studied whether the ratio myoglobin over FABP in plasma can be used to distinguish myocardial from skeletal Methods Results were assayed immunochemically tissue samples human heart serial 22 patients with acute infarction (AMI), 9 undergoing aortic surgery (causing injury muscles), 10 cardiac surgery. In tissue, myoglobin/FABP was 4.5 muscles varied 21 73. After AMI,...
Background— Blood transfusion is associated with acute kidney injury (AKI) after transcatheter aortic valve implantation (TAVI). We sought to elucidate in more detail the relation between blood and AKI its effects on short- long-term mortality. Methods Results— Nine hundred ninety-five patients stenosis underwent TAVI Medtronic CoreValve or Edwards Valve 7 centers. was defined by Academic Research Consortium (absolute increase serum creatinine ≥0.3 mg/dL [≥26.4 μmol/L] ≥50% ≤72 hours)....
The Hilbert transform has been used to characterize wave propagation and detect phase singularities during cardiac fibrillation. Two mapping modalities have used: optical (used map atria ventricles) contact electrode only ventricles). Due specific morphology of atrial electrograms, reconstruction electrograms in the is challenging not investigated detail. Here, we explore properties applied unipolar epicardial devise a method for robust using transform. We idealized signals obtained from...
Acute kidney injury (AKI) and intestinal negatively impact patient outcome after cardiac surgery. Enhanced nitric oxide (NO) consumption due to intraoperative intravascular hemolysis, may play an important role in this setting. This study investigated the of hemolysis on plasma NO consumption, AKI, tissue damage, surgery.Hemolysis (by extracellular (free) hemoglobin; fHb), NO-consumption, fHb-binding capacity by haptoglobin (Hp), renal tubular (using urinary N-Acetyl-β-D-glucosaminidase;...
Objectives: To assess in-hospital neurologic (CNS) complications in adult patients undergoing veno-venous extracorporeal membrane oxygenation for respiratory failure. Design: Retrospective analysis of the Extracorporeal Life Support Organization’s data registry. Setting: Data reported to Organization from 350 international centers during 1992–2015. Patients: Adults (≥ 18 yr old) supported with Interventions: None. Measurements and Main Results: We included 4,988 adults Neurologic injury was...
To explore technical challenges of phase singularity (PS) mapping during atrial fibrillation (AF) using direct contact electrograms.AF was performed in high-density epicardial recordings human paroxysmal (PAF) or persistent (PersAF) (N = 20 pts) AF with an array 16 × electrodes placed on epicardium. PS points were detected subsets forming rings varying sizes.PS detection a 2 electrode ring identified 0.88 ± 1.00 PS/s PAF group and 3.91 2.51 per s PersAF (p < 0.001) 2.4 cm area. All had short...
Objectives Differentiation between normal and abnormal features of vascular ageing is crucial, as the latter associated with adverse outcomes. The aortic process accompanied by gradual luminal dilatation reduction vessel compliance. However, influence age on longitudinal dimensions geometry has not been well studied. This study aims to describe evolution length shape throughout life. Methods A total 210 consecutive patients were prospectively enrolled in this cross-sectional single-centre...
OBJECTIVES: Refractory postcardiotomy cardiogenic shock complicating cardiac surgery yields nearly 100% mortality when untreated. Use of venoarterial extracorporeal membrane oxygenation for has increased worldwide recently. The aim the current analysis was to outline trends in use, changing patient profiles, and in-hospital outcomes including complications patients undergoing shock. DESIGN: Analysis life support organization registry from January 2010 December 2018. SETTING: Multicenter...
Although catheter ablation (CA) is successful for the treatment of paroxysmal atrial fibrillation (AF), results are less satisfactory in persistent AF. Hybrid (HA) better outcomes patients with (persAF), as it combines a thoracoscopic epicardial and transvenous endocardial approach single procedure.The purpose this study was to compare effectiveness safety HA CA prospective, superiority, unblinded, randomized controlled trial.Forty-one ablation-naive (long-standing)-persAF were (n = 19) or...