A5036417910- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Heart Failure Treatment and Management
- Cardiovascular Issues in Pregnancy
- Cardiac Arrhythmias and Treatments
- Pulmonary Hypertension Research and Treatments
- Central Venous Catheters and Hemodialysis
- Trauma Management and Diagnosis
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Organ Transplantation Techniques and Outcomes
- Aortic Disease and Treatment Approaches
- Acute Kidney Injury Research
- Viral Infections and Immunology Research
- Airway Management and Intubation Techniques
- Trauma and Emergency Care Studies
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Renal Transplantation Outcomes and Treatments
- Tracheal and airway disorders
Boston Children's Hospital
2016-2025
Harvard University
2016-2025
Boston University
2013-2024
Children's Hospital at Westmead
2024
The University of Sydney
2024
Case Western Reserve University
2024
Rainbow Babies & Children's Hospital
2024
Boston Children's Museum
2013-2023
Battelle
2023
Fenway Health
2023
Data on extracorporeal life support (ECLS) use and survival submitted to the Extracorporeal Life Support Organization's data registry from inception of in 1989 through July 1, 2016, are summarized this report. The contained information 78,397 ECLS patients with 58% hospital discharge. centers providing have increased worldwide. adults respiratory cardiac failure represented largest growth recent time period. indications expanding, it is increasingly being used cardiopulmonary resuscitation...
Extracorporeal membrane oxygenation (ECMO) may provide mechanical pulmonary and circulatory support for patients with cardiogenic shock refractory to conventional medical therapy. Prediction of survival in these assist management comparison results from different centers. To identify pre-ECMO factors which predict requiring ECMO create the after veno-arterial-ECMO (SAVE)-score. Patients treated veno-arterial between January 2003 December 2013 were extracted international Life Support...
In this article, summary data from the annual international Extracorporeal Life Support Organization (ELSO) Registry Reports through July 2012 are presented. Nearly 51,000 patients have received extracorporeal life support (ECLS). Of patients, 50% (>25,000) were neonatal respiratory failure, with a 75% overall survival to discharge or transfer. Congenital diaphragmatic hernia remains major use of ECLS in population 51% survival. for pediatric failure has nearly doubled since 2000,...
The purpose of this report is to describe the international growth, outcomes, complications, and technology used in pediatric extracorporeal life support (ECLS) from 2009 2015 as reported by participating centers Extracorporeal Life Support Organization (ELSO). To date, there are 59,969 children who have received ECLS ELSO Registry; among those, 21,907 since with an overall survival hospital discharge rate 61%. In 2009, 2,409 cases were performed at 157 centers. By 2015, that number grew...
Children listed for heart transplantation face the highest waiting list mortality in solid-organ medicine. We examined since pediatric allocation system was revised 1999 to determine whether is prioritizing patients optimally and identify specific high-risk populations that may benefit from emerging cardiac assist devices.We conducted a multicenter cohort study using US Scientific Registry of Transplant Recipients. All children <18 years age who were transplant between 2006 included. Among...
Objective: To empirically derive the optimal measure of pharmacologic cardiovascular support in infants undergoing cardiac surgery with bypass and to assess association between this score clinical outcomes a multi-institutional cohort. Design: Prospective, cohort study. Setting: Cardiac ICUs at four academic children's hospitals participating Pediatric Critical Care Consortium during study period. Patients: Children younger than 1 year time treated postoperatively ICU. Interventions: None....
Extracorporeal membrane oxygenation (ECMO) has been used to support cardiorespiratory function during pediatric cardiopulmonary resuscitation (CPR). We report on outcomes and predictors of in-hospital mortality after ECMO CPR (E-CPR).Outcomes for patients aged <18 years using E-CPR were analyzed with data from the Life Support Organization, determined. Of 26,242 uses reported, 695 (2.6%) (n=682 patients). Survival hospital discharge was 38%. In a multivariable model, pre-ECMO factors such as...
To elucidate the epidemiology, complication profiles, hospital outcome, and predisposing factors of CNS complications occurring during venoarterial extracorporeal membrane oxygenation in adults.Retrospective analysis Extracorporeal Life Support Organization registry.Data reported to by 230 centers from 1992 2013.Patients more than 16 years old supported with a single-run oxygenation.None.We examined 4,522 adult patients included registry. Venoarterial was used for cardiac dysfunction 3,005...
Although extracorporeal cardiopulmonary resuscitation (E-CPR) can result in survival after failed conventional CPR (C-CPR), no large, systematic comparison of pediatric E-CPR and continued C-CPR has been reported.Consecutive patients <18 years old with events ≥10 minutes duration reported to the Get With Guidelines-Resuscitation registry between January 2000 December 2011 were identified. Hospitals grouped by teaching status location. Primary outcome was discharge. Regression modeling...
Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is an effective rescue therapy for severe cardiorespiratory failure, but morbidity and mortality are high. We hypothesised that survival decreases with longer VA ECMO treatment. examined the Extracorporeal Life Support Organization (ELSO) registry a relationship between duration in-hospital mortality, covariates including indication support.All runs from ELSO database 2002 to 2012 were extracted. Multiple non-VA excluded. Runs...
The aim of this study was to develop and validate a score accurately predict the probability death for adult extracorporeal cardiopulmonary resuscitation (ECPR).
Survival of children with in-hospital cardiac arrest that does not respond to conventional cardiopulmonary resuscitation (CPR) is poor. We report on survival and early neurological outcomes heart disease supported rapid-response extracorporeal membrane oxygenation (ECMO) aid (ECPR).Children ECPR were identified from our ECMO database. Demographic, CPR, details associated mortality evaluated using multivariable logistic regression. Pediatric overall performance category pediatric cerebral...
Recent studies have revealed increased morbidity and mortality rates in term neonates without birth defects who were delivered before 39 weeks of completed gestation. We sought to determine if a similar association exists between gestational age at delivery adverse outcomes with critical congenital heart disease, particular interest those born 37 38 weeks' gestation.We studied 971 consecutive had disease known admitted our cardiac ICU from 2002 through 2008. Gestational was stratified into 5...
Extracorporeal membrane oxygenation (ECMO) to aid failed cardiopulmonary resuscitation (CPR) in children is associated with a high incidence of neurologic injury. We sought identify risk factors for acute injury undergoing ECMO CPR (E-CPR).Retrospective cohort study using data reported the Life Support Organization registry.Multi-institutional data.Patients <18 years age E-CPR during 1992-2005.None.We defined as occurrence brain death, infarction, or intracranial hemorrhage identified by...
Resuscitation of pediatric cardiac patients involves unique and complex physiology, requiring multidisciplinary collaboration teamwork. To optimize team performance, we created a Crisis Resource Management training course that addressed both teamwork technical skill needs for the intensive care unit. We sought to determine whether participation improved caregiver comfort confidence levels regarding future resuscitation events.We developed simulation-based, in situ curriculum using unit...
Extracorporeal membrane oxygenation (ECMO) has served for >2 decades as the standard of care US children requiring mechanical support a bridge to heart transplantation. Objective data on safety and efficacy ECMO this indication are limited. We describe outcomes transplantation serve performance benchmarks emerging miniaturized assist devices intended replace ECMO.Data from Life Support Organization Registry Organ Procurement Transplant Network database were merged identify supported with...