A5091694136- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Infant Nutrition and Health
- Cardiac Arrest and Resuscitation
- Clinical Nutrition and Gastroenterology
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Neonatal Health and Biochemistry
- Fatty Acid Research and Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Airway Management and Intubation Techniques
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Metabolism and Genetic Disorders
- Non-Invasive Vital Sign Monitoring
- Glioma Diagnosis and Treatment
- Ultrasound in Clinical Applications
- Cardiac Structural Anomalies and Repair
- COVID-19 and healthcare impacts
- Emergency and Acute Care Studies
- Acute Kidney Injury Research
- Neonatal and fetal brain pathology
University of Udine
2016-2025
Città della Speranza Foundation
2020-2024
Ospedale Santa Maria della Misericordia di Udine
2016-2024
Azienda Unità Sanitaria Locale di Ferrara
2024
Presidio Ospedaliero
2023
University of Milan
2023
Cambridge University Press
2011-2023
New York University Press
2023
Azienda Sanitaria Universitaria Integrata di Trieste
2022
King's College London
2022
Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause encephalitis <1% of infected individuals. We show that ∼35% patients hospitalized for WNV disease (WNVD) six independent cohorts from the EU and USA carry auto-Abs neutralizing IFN-α and/or -ω. The prevalence these antibodies highest with (∼40%), silent as low general population. odds ratios WNVD relative to those without them population range 19.0 (95% CI 15.0–24.0, P value <10–15) only...
Prognostic models applied in medicine must be validated on independent samples, before their use can recommended. The assessment of calibration, i.e., the model's ability to provide reliable predictions, is crucial external validation studies. Besides having several shortcomings, statistical techniques such as computation standardized mortality ratio (SMR) and its confidence intervals, Hosmer-Lemeshow statistics, Cox calibration test, are all non-informative with respect across risk classes....
The Covid-19 outbreak and the subsequent lockdown have profoundly impacted families' daily life, challenging their psychological resilience. Our study aimed to investigate immediate consequences of pandemic on Italian parents children focusing internalizing post-traumatic symptoms. We also wanted explore impact possible risk resilience factors, e.g., lifestyle behaviors, emotional cognitive beliefs, children's reaction emergency distress. An online survey was administered during country's...
The COVID-19 pandemic affected pediatric emergency department (ED) visits for traumatic injuries. This retrospective study analyzed data from Merano Hospital, Italy, spanning January 2018 to October 2022, focusing on standardized ED per 1000 orthopedic attendances. Findings indicated a significant decline in at the pandemic’s onset (March 2020), followed by gradual increase until April when measures ended. Fracture and procedure rates remained stable, while dislocations saw temporary...
Abstract Introduction The aim of the study was to evaluate effects high-dose fenoldopam, a selective dopamine-1 receptor, on renal function and organ perfusion during cardiopulmonary bypass (CPB) in infants with congenital heart disease (CHD). Methods A prospective single-center randomized double-blind controlled trial conducted pediatric cardiac surgery department. We younger than 1 year CHD biventricular anatomy (with exclusion isolated ventricular atrial septal defect) receive blindly...
The aim of this study was to compare high-flow nasal cannula (HFNC) and conventional O2 therapy (OT) in paediatric cardiac surgical patients; the primary objective evaluate whether HFNC able improve PaCO2 elimination first 48 h after extubation postoperatively. We conducted a randomized, controlled trial pediatric patients under 18 months age. At beginning weaning ventilation, were randomly assigned either following groups: OT or HFNC. Arterial blood samples collected before at time points:...
The restrictive measures required to face the recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may impact patterns healthcare utilization. Our aim was provide an insight into change in use a pediatric emergency department (ED) during SARS-CoV-2 pandemic. medical records children seen our ED March and April 2020 were retrospectively reviewed. Consequently, these compared 2018 2019 from same time period other control periods (January-February 2020, July-August...
Quarantine and isolation measures during COVID-19 pandemic may have caused additional stress challenged the mental health of youth. Aim study is to investigate impact on neuropsychological disorders (NPD) Italian children adolescents provide general pediatric recommendations.A retrospective multicenter observational was planned by Pediatric Society (SIP) explore access Emergency Departments (pED) for evaluation symptoms, collecting classification codes diagnoses between March 1, 2019 2,...
Despite the high burden of respiratory disease, no spirometry reference values for African children are available.Investigate whether Global Lung Initiative (GLI-2012) appropriate in sub-Saharan Africa and assess impact malnutrition on lung function.Anthropometry were obtained aged 6 to 12 years from urban semiurban schools three countries. Spirometry z-scores derived using GLI-2012 prediction equations Americans. Thinness (body mass index z-score < -2) was a surrogate malnutrition. outcomes...
The aim of this article is to describe the epidemiology and factors associated with acute neurologic injury in neonates congenital heart disease (CHD) undergoing extracorporeal membrane oxygenation (ECMO). It a retrospective cohort study. Multi-institutional data for purposes study were obtained from life support organization registry Neonates CHD supported ECMO during 2005-2010. Of 1,898 ECMO, 273 (14%) had injury. Birth weight less than 3 kg (odds ratio [OR]: 1.5; 95% confidence intervals...
Non-invasive delivery of nebulized surfactant has been a neonatology long-pursued goal. Nevertheless, the clinical efficacy remains inconclusive, in part, due to great technical challenges depositing drugs lungs preterm infants. The aim this study was investigate feasibility delivering (poractant alfa) vitro and vivo with an adapted, neonate-tailored aerosol strategy. Particle size distribution undiluted poractant alfa aerosols generated by customized eFlow-Neos nebulizer system determined...
Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) differ for triggers, mode of start, associated symptoms, evolution, and biochemical traits. Therefore, serious attempts are underway to partition them into subgroups useful a personalized medicine approach the disease. Here, we investigated clinical traits in 40 ME/CFS patients sex- age-matched healthy controls. Particularly, analyzed serum levels some cytokines, Fatty Acid Binding Protein 2 (FAPB-2), tryptophan, its...
Abstract Pediatric (PARDS) and neonatal (NARDS) acute respiratory distress syndrome have different age-specific characteristics definitions. Trials on surfactant for ARDS in children neonates been performed well before the PARDS NARDS definitions yielded conflicting results. This is mainly due to heterogeneity study design reflecting historic lack of pathobiology knowledge. We reviewed available clinical preclinical data create an expert consensus aiming inform future research steps advance...
The goal was to study exogenous surfactant disaturated phosphatidylcholine (DSPC) kinetics in preterm infants with respiratory distress syndrome (RDS) who were treated 100 or 200 mg/kg porcine surfactant.Sixty-one RDS undergoing mechanical ventilation received, within 24 hours after birth, (N = 40) 21) mixed [U-(13)C]dipalmitoylphosphatidylcholine. Clinical and parameters recorded, DSPC half-life pool size endogenous synthesis rate calculated.Clinical characteristics short-term outcomes did...