A5023757905- Neonatal Respiratory Health Research
- Ovarian cancer diagnosis and treatment
- Neuroscience of respiration and sleep
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Respiratory Support and Mechanisms
- Cancer Research and Treatments
- DNA Repair Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Cardiac Imaging and Diagnostics
- Inhalation and Respiratory Drug Delivery
- Renal cell carcinoma treatment
- Forensic Anthropology and Bioarchaeology Studies
- PARP inhibition in cancer therapy
- Cancer, Hypoxia, and Metabolism
- Protist diversity and phylogeny
- Pancreatic and Hepatic Oncology Research
- Autoimmune and Inflammatory Disorders Research
- Cancer-related Molecular Pathways
- Microbial Community Ecology and Physiology
- CRISPR and Genetic Engineering
- Microtubule and mitosis dynamics
- Advanced MRI Techniques and Applications
- RNA modifications and cancer
- Renal and related cancers
University of Brescia
2005-2025
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2016-2025
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2025
Mario Negri Institute for Pharmacological Research
2014-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2024
Chiesi (Italy)
2011-2023
Chiesi (France)
2023
Centro Cardiologico Monzino
2021-2022
IRCCS Humanitas Research Hospital
2022
Chiesi Foundation
2019-2021
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. On basis of its histopathology and molecular-genomic changes, has been divided into subtypes, each with distinct biology outcome. The aim this study was to develop a panel patient-derived EOC xenografts that recapitulate molecular biologic heterogeneity human cancer. Thirty-four were successfully established, either subcutaneously or intraperitoneally, in nude mice. histologically similar corresponding patient tumor...
Targeting Chk1 protein kinase can enhance the antitumor effects of radio- and chemotherapy. Recent evidence disclosed a role in unperturbed cell proliferation survival, implying that inhibitors could also be effective as single agents tumors with specific genetic background. To identify genes synthetic lethality Chk1, we did high-throughput screening using siRNA library directed against 719 human kinases ovarian cancer line OVCAR-5, resistant to inhibitors. Wee1 tyrosine was most significant...
Abstract Gemcitabine is considered the standard first-line therapy for patients with advanced pancreatic cancer. More recent strategies have focused on improving efficacy of gemcitabine by either method delivery or combining other non-cross-resistant chemotherapy agents small-molecule drugs. However, clinical benefits, response rates, and duration responses been modest. Deoxycytidine kinase (dCK) rate-limiting enzyme involved in metabolism gemcitabine. The expression dCK has postulated to be...
Abstract Porotic hyperostosis, characterized by small and localized perforations on the surface of cranial bones, is considered a good indicator for assessing health nutritional status past human populations. The most widely accepted theory at present indicates that anemias, either acquired or genetic origin, are responsible bony lesions described as porotic hyperostosis. In this paper, prevalence these in two skeletal samples from Latium (central Italy) was used to evaluate life conditions...
The virtual lack of well-characterized metastatic pancreatic cancer tissues for study has limited systematic studies the process this deadly disease. To address important issue, we have instituted a rapid autopsy protocol collection high quality from patients with cancer, called Gastrointestinal Cancer Rapid Medical Donation Program (GICRMDP). At time preparation manuscript, 20 and one patient colon undergone in association GICRMDP. average interval achieved these 21 was 8.0 hours, more than...
Background: interleukin (IL)-1 inhibitors have been suggested as possible therapeutic options in a large number of old and new clinical entities characterized by an IL-1 driven pathogenesis. Objectives: to perform nationwide snapshot the on-label off-label use anakinra (ANA) canakinumab (CAN) for different conditions both children adults. Methods: we retrospectively collected demographic, clinical, data from adult pediatric patients treated with January 2008 July 2016. Results: 526 treatment...
Aluminium (Al) is a neurotoxic metal and Al exposure may be factor in the aetiology of various neurodegenerative diseases such as Alzheimer's disease (AD). The major pathohistological findings AD brain are presence neuritic plaques containing beta-amyloid (Abeta) which interfere with neuronal communication. Moreover, it has been observed that GRP78, stress-response protein induced by conditions adversely affect endoplasmic reticulum (ER) function, reduced patients. In this study, we...
Resveratrol is a non flavonoid polyphenol compound present in many plants and fruits and, at especially high concentrations, the grape berries of Vitis vinifera. This has strong bioactivity its cytoprotective action been demonstrated, however concentrations drug exhibits also an effective anti-proliferative action. We recently showed ability to abolish effects oxidative stress cultured cells. In this work we assayed resveratrol as antiproliferative antiviral fibroblasts. Studies by other...
Non-invasive delivery of nebulized surfactant has been a neonatology long-pursued goal. Nevertheless, the clinical efficacy remains inconclusive, in part, due to great technical challenges depositing drugs lungs preterm infants. The aim this study was investigate feasibility delivering (poractant alfa) vitro and vivo with an adapted, neonate-tailored aerosol strategy. Particle size distribution undiluted poractant alfa aerosols generated by customized eFlow-Neos nebulizer system determined...
Epithelial ovarian cancer is the most lethal gynecological and high mortality due to frequent presentation at advanced stage, primary or acquired resistance platinum-based therapy.We developed three new models of patient-derived xenografts (ovarian PDXs) resistant cisplatin (cDDP) after multiple in vivo drug treatments. By different complementary approaches based on integrated metabolomics (both targeted untargeted mass spectrometry-based techniques), gene expression, functional assays...
Objective The aim of this paper is to present the AutoInflammatory Disease Alliance (AIDA) international Registry dedicated Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) syndrome, describing its design, construction, and modalities dissemination. Methods This a clinical, physician-driven, population- electronic-based instrument designed for retrospective prospective collection real-life data. Data gathering based on Research Electronic Capture (REDCap) tool intended obtain...
MKK4 (MAP2K4/SEK1) is a member of the mitogen-activated protein kinase family, originally identified as involved in stress-activated pathway by directly phosphorylating c-Jun NH2-terminal kinase. genetic inactivation has been observed subset pancreatic carcinomas, implicating deregulation carcinogenesis. We evaluated Mkk4 expression patterns immunohistochemical labeling series 60 resected primary infiltrating adenocarcinomas (24 cases with known status), and 14 different tissue arrays...
Solid tumors appear to contain a subpopulation of cells (tumor-initiating cells, TICs) that not only drives and sustains tumor growth, but is possibly responsible for recurrence. We isolated, after enzymatic digestion primary ovarian carcinoma samples, propagating as non-adherent spheres in medium suitable stem cells. These were able self-renew vitro, suggested by PKH-26 staining studies, tumorigenic acquired an epithelial morphology when grown FBS-supplemented medium, losing their...
Abstract Purpose of the present paper is to point out design, development and deployment AutoInflammatory Disease Alliance (AIDA) International Registry dedicated pediatric adult patients with Behçet’s disease (BD). The a clinical physician-driven non-population- electronic-based instrument implemented for retrospective prospective collection real-life data about demographics, clinical, therapeutic, laboratory, instrumental socioeconomic information from BD patients; based on Research...
To confirm the presence of different disease phenotypes pediatric SAPHO syndrome (pSAPHO) based on their skin manifestations in a large cohort Italian patients. pSAPHO were enrolled Eurofever Registry and data retrospectively analysed. Patients divided depending into an Acne-Hidradenitis suppurativa (HS) group Palmoplantar Pustulosis-Psoriasis Vulgaris (PPP-PV) compared with patients without (chronic non-bacterial osteomyelitis, CNO). Comparison frequencies between groups was performed by...
Pseudomyogenic haemangioendotheliomas (PMH) are exceedingly rare, mostly occurring in soft tissue, with malignant cases even more uncommon. In this report, we present a case of 28-year-old male initially suspected having fibroblastic osteosarcoma the right femur, which was then correctly diagnosed as primary pseudomyogenic hemangioendothelioma bone synchronous metastases to other skeletal segments. Molecular analysis through targeted RNA sequencing confirmed correct diagnosis, revealing...