A5035082629- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Inflammatory mediators and NSAID effects
- Neuropeptides and Animal Physiology
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Receptor Mechanisms and Signaling
- Phagocytosis and Immune Regulation
- Neuroscience and Neuropharmacology Research
- S100 Proteins and Annexins
- CAR-T cell therapy research
- Estrogen and related hormone effects
- Genomics, phytochemicals, and oxidative stress
- Bone and Dental Protein Studies
- Graphene and Nanomaterials Applications
- Immune Response and Inflammation
- Cancer Treatment and Pharmacology
- Advanced Drug Delivery Systems
- Antioxidant Activity and Oxidative Stress
- Curcumin's Biomedical Applications
- Computational Drug Discovery Methods
- Advancements in Transdermal Drug Delivery
- Eicosanoids and Hypertension Pharmacology
University of Turin
2015-2024
Presidio Ospedaliero
2023
Amgen (United States)
1998
Institute of Pharmacology
1992
The transcription factor nuclear erythroid 2-related 2 (Nrf2) is considered as the master regulator of antioxidant and cytoprotective gene expressions. Moreover, it plays a pivotal role in cancer progression. Nrf2 mediates adaptive response which contributes to resistance chemotherapeutic pro-oxidant drugs, such cisplatin (CDDP), various tumors, including bladder cancers. For this reason, could be promising target overcome chemoresistance. There are several known pharmacological inhibitors;...
Resveratrol and oxyresveratrol are natural polyphenolic stilbenes with several important pharmacological activities. However, low solubility aqueous instability the major limitations in their drug delivery applications. In present work, we demonstrated encapsulation of resveratrol nanosponge to improve stability. Several characterization techniques were used confirm both molecules within nanosponges. The high efficiency (77.73%) (80.33%) was achieved Transmission electron microscopy...
Glioblastoma, the most common primary brain tumor in adults, has an inauspicious prognosis, given that overcoming blood-brain barrier is major obstacle to pharmacological treatment of tumors. As neoangiogenesis plays a key role glioblastoma growth, US Food and Drug Administration approved bevacizumab (BVZ), antivascular endothelial growth factor antibody for recurrent patients whose initial therapy failed. In this experimental work, BVZ was entrapped solid lipid nanoparticles (SLNs) prepared...
Camptothecin (CPT), a pentacyclic alkaloid, is an inhibitor of DNA Topoisomerase-I and shows wide spectrum anti-cancer activities. The use CPT has been hampered by poor aqueous solubility high degradation rate. Previously, it reported that encapsulated in β-cyclodextrin-nanosponges (CN-CPT) overcomes these disadvantages improves the CPT's inhibitory effect on DU145 prostate tumor cell lines, PC-3 growth vitro. This work extends observations showing CN-CPT significantly inhibits adhesion...
Aim: To develop an innovative delivery system for temozolomide (TMZ) in solid lipid nanoparticles (SLN), which has been preliminarily investigated the treatment of melanoma. Materials and Methods: SLN-TMZ was obtained through fatty acid coacervation. Its pharmacological effects were assessed compared with free TMZ vitro vivo models melanoma glioblastoma. Results: Compared to standard TMZ, exerted larger effects, when cell proliferation cells, neoangiogeneis evaluated. also inhibited growth...
Abstract Metastasis formation requires active energy production and is regulated at multiple levels by mitochondrial metabolism. The hyperactive metabolism of cancer cells supports their extreme adaptability plasticity facilitates resistance to common anticancer therapies. In spite the potential relevance a metastasis metabolic control therapy, so far, limited experience available in this direction. Here, we evaluated effect recently described α-ketoglutarate dehydrogenase (KGDH) inhibitor,...
Background: Solid lipid nanoparticles (SLNs) are attractive drug delivery systems for lipophilic molecules like curcumin (CURC) with low chemical stability. Methods: A simple, innovative, and cold-operating method, named "cold dilution of microemulsion" is developed by the authors to produce SLNs. An oil-in-water microemulsion (µE), whose disperse phase consisted a solution trilaurin in partially water-miscible solvent, was prepared after mutually saturating solvent water. Trilaurin SLNs...
Doxorubicin (DOX) is an anthracycline widely used in cancer therapy and particular breast treatment. The treatment with DOX appears successful, but it limited by a severe cardiotoxicity. This work evaluated the vitro vivo anticancer effect of new formulation β-cyclodextrin nanosponges containing (BNS-DOX). BNS-DOX effectiveness was human mouse cell lines terms on growth, cycle distribution, apoptosis induction; BALB-neuT mice developing spontaneous biodistribution, growth inhibition, heart...
Solid lipid nanoparticles (SLNs) comprise a versatile drug delivery system that has been developed for the treatment of variety diseases. The present study will investigate feasibility entrapping an active doxorubicin prodrug (a squalenoyl-derivative) in SLNs. derivative-loaded SLNs are spherically shaped, have mean diameter 300–400 nm and show 85% w/w entrapment efficiency. effects on cell growth loaded SLNs, free examined using cytotoxicity colony-forming assays both human ovarian cancer...