Gerard Espinosa
A5044648562- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Systemic Sclerosis and Related Diseases
- Platelet Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Retinal and Optic Conditions
- Monoclonal and Polyclonal Antibodies Research
- Otitis Media and Relapsing Polychondritis
- Blood disorders and treatments
- Diabetes and associated disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Inflammatory Myopathies and Dermatomyositis
- Peripheral Neuropathies and Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatitis C virus research
- Autoimmune and Inflammatory Disorders Research
- COVID-19 Clinical Research Studies
- Complement system in diseases
- Inflammasome and immune disorders
- Liver Diseases and Immunity
- Eosinophilic Disorders and Syndromes
Hospital Clínic de Barcelona
2016-2025
Universitat de Barcelona
2016-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015-2025
Karolinska University Hospital
2024
Karolinska Institutet
2024
Center for Rheumatology
2024
Fundació Clínic per a la Recerca Biomèdica
2019-2023
Hospital Universitari de Vic
2016-2023
Autoimmune Technologies (United States)
2010-2021
Sorbonne Université
2021
To assess the prevalence of main causes morbi-mortality in antiphospholipid syndrome (APS) during a 10-year-follow-up period and to compare frequency early manifestations with those that appeared later.In 1999, we started an observational study 1000 APS patients from 13 European countries. All had medical histories documented when entered into were followed prospectively ensuing 10 years.53.1% primary APS, 36.2% associated systemic lupus erythematosus 10.7% other diseases. Thrombotic events...
Abstract Objective To assess the main causes of death and prognostic factors that influence mortality in patients with catastrophic antiphospholipid syndrome (CAPS). Methods We analyzed case reports 250 included CAPS Registry up to February 2005. identify for CAPS, we compared clinical immunologic features types treatment who died those survived. Results Recovery occurred 56% episodes 44%. Cerebral involvement, consisting mainly stroke, cerebral hemorrhage, encephalopathy, was considered...
To identify the main causes of morbidity and mortality in patients with antiphospholipid syndrome (APS) during a 5-year period to determine clinical immunological parameters prognostic significance.The features cohort 1000 APS from 13 European countries who had been followed up 1999 2004 were analysed.200 (20%) developed APS-related manifestations study period. Recurrent thrombotic events appeared 166 (16.6%) most common strokes (2.4% total cohort), transient ischaemic attacks (2.3%), deep...
Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes early diagnosis and effective treatment, issues that may be addressed if patients could classified into groups defined by molecular pattern. This study was undertaken to identify clusters for reclassifying diseases independently clinical diagnosis.Unsupervised clustering integrated whole blood transcriptome methylome cross-sectional data on 955 with 7 267 healthy controls undertaken. In addition, an inception cohort...
There is currently no approved treatment for primary Sjögren's syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies -in part- because of the heterogeneity clinical manifestation and pathophysiology disease. Finding common molecular signatures among patient subgroups could improve our understanding etiology, facilitate development targeted therapeutics. Here, we report, cross-sectional cohort, classification scheme syndrome patients based on...
Autoantibodies targeting intracellular proteins are common in various autoimmune diseases. In the context of myositis, pathologic significance these autoantibodies has been questioned due to assumption that cannot enter living muscle cells. This study aims investigate validity this assumption.
<h3>OBJECTIVE</h3> To define the pattern of disease expression in patients with childhood onset systemic lupus erythematosus (SLE). <h3>METHODS</h3> Prospective analysis clinical manifestations and immunological features 34 whom first appeared from a series 430 unselected SLE. <h3>RESULTS</h3> Thirty one (91%) group were female three male (9%) (ratio female/male, 10/1, no difference compared adult group). Mean age this at was 11 years (range 5–14) 32 (15–48) for remaining patients. The more...
<b>Objective:</b> To describe the characteristics of patients with catastrophic antiphospholipid syndrome (APS) included in International Registry this condition (CAPS registry) and to analyse value recently proposed preliminary criteria for classification APS. <b>Methods:</b> A review first 220 website based CAPS registry was undertaken their were tested; 175 unselected systemic lupus erythematosus or APS, both, acted as controls. <b>Results:</b> The mean age 38 (14) years (range 7 74), a...
BACKGROUND Based on recent evidence showing that endothelin-1 stimulates several activation mechanisms neutrophils, the aim of present study was to analyze effects neutrophil adhesion endothelial cells and accumulation in heart. METHODS AND RESULTS The experiments included (1) 51Cr-labeled human neutrophils bovine culture both presence absence monoclonal antibodies against alpha- beta-subunits integrins; (2) surface expression beta-integrin antigens; (3) isolated perfused rabbit heart; (4)...
Congenital heart block (CHB) is presumed to be caused by transplacental passage of maternal immunoglobulin against Ro and La ribonucleoproteins. The recurrence rate in subsequent pregnancies following the birth a child with CHB approximately 19%. purpose this study was determine whether intravenous (IVIG) therapy could prevent development fetuses high-risk pregnant women.A total 24 22 women who had previous pregnancy which developed, were over age 18 years, <12 weeks pregnant, anti-Ro,...
To report the anatomical pattern and etiological spectrum of uveitis in an urban multi-ethnic population from Barcelona, Spain. General specific epidemiological data for most prevalent aetiologies are also calculated.A cross-sectional study consecutive cases was performed between 1 January 2009 31 December 2012. Exogenous endophthalmitis, surgery-related, post-traumatic toxic along with masquerade syndromes were excluded. Anatomical (Standard Uveitis Nomenclature criteria) aetiological...