Dinesh Khanna
A5073269240- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Myopathies and Dermatomyositis
- Dermatologic Treatments and Research
- Mast cells and histamine
- Pulmonary Hypertension Research and Treatments
- Rheumatoid Arthritis Research and Therapies
- Autoimmune Bullous Skin Diseases
- Gout, Hyperuricemia, Uric Acid
- Systemic Lupus Erythematosus Research
- Connective Tissue Growth Factor Research
- Medical Imaging and Pathology Studies
- Eosinophilic Disorders and Syndromes
- Spondyloarthritis Studies and Treatments
- Urticaria and Related Conditions
- Diagnosis and Treatment of Venous Diseases
- Eosinophilic Esophagitis
- Case Reports on Hematomas
- Autoimmune and Inflammatory Disorders Research
- Skin Diseases and Diabetes
- Skin and Cellular Biology Research
- Lymphoma Diagnosis and Treatment
- Celiac Disease Research and Management
- Voice and Speech Disorders
- Dysphagia Assessment and Management
University of Michigan
2016-2025
Scleroderma Foundation
2016-2025
Michigan Medicine
2013-2025
Michigan United
2013-2024
University of California, Los Angeles
2010-2023
Ann Arbor VA Medical Center
2023
University of Florence
2021-2023
University of Washington
2016-2023
Trinity Health
2023
Horizon Therapeutics (United States)
2023
Objective The 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis (SSc) lack sensitivity early SSc and limited cutaneous SSc. present work, by a joint committee the ACR European League Against Rheumatism (EULAR), was undertaken purpose developing new Methods Using consensus methods, 23 candidate items were arranged in multicriteria additive point system with threshold to classify cases as reduced clustering simplifying weights. tested 1) determining...
<h3>Objective</h3> The 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis (SSc) lack sensitivity early SSc and limited cutaneous SSc. present work, by a joint committee the ACR European League Against Rheumatism (EULAR), was undertaken purpose developing new <h3>Methods</h3> Using consensus methods, 23 candidate items were arranged in multicriteria additive point system with threshold to classify cases as reduced clustering simplifying weights. tested...
To develop new classification criteria for systemic lupus erythematosus (SLE) jointly supported by the European League Against Rheumatism (EULAR) and American College of Rheumatology (ACR).This international initiative had four phases. 1) Evaluation antinuclear antibody (ANA) as an entry criterion through systematic review meta-regression literature generation Delphi exercise, early patient cohort, a survey. 2) Criteria reduction nominal group technique exercises. 3) definition weighting...
Guidelines and recommendations
This criteria set has been approved by the American College of Rheumatology (ACR) Board Directors and European League Against Rheumatism (EULAR) Executive Committee as Provisional.This signifies that quantitatively validated using patient data, but it not undergone validation based on an external data set.All ACR/EULAR-approved sets are expected to undergo intermittent updates.The is independent, professional, medical scientific society which does guarantee, warrant, or endorse any...
<h3>Objective</h3> Earlier detection of pulmonary arterial hypertension (PAH), a leading cause death in systemic sclerosis (SSc), facilitates earlier treatment. The objective this study was to develop the first evidence-based algorithm for PAH SSc. <h3>Methods</h3> In cross-sectional, international conducted 62 experienced centres from North America, Europe and Asia, adults with SSc at increased risk (SSc >3 years predicted diffusing capacity carbon monoxide <60%) underwent broad panel...
Objective Remission in rheumatoid arthritis (RA) is an increasingly attainable goal, but there no widely used definition of remission that stringent achievable and could be applied uniformly as outcome measure clinical trials. This work was undertaken to develop such a definition. Methods A committee consisting members the American College Rheumatology, European League Against Rheumatism, Outcome Measures Rheumatology Initiative met guide process review prespecified analyses from RA The...
Guidelines and recommendations developed and/or endorsed by the American College of Rheumatology (ACR) are intended to provide guidance for particular patterns practice not dictate care a patient.The ACR considers adherence these guidelines be voluntary, with ultimate determination regarding their application made physician in light each patient's individual circumstances.Guidelines promote beneficial or desirable outcomes but cannot guarantee any specific outcome.Guidelines subject periodic...
To provide guidance for the management of gout, including indications and optimal use urate-lowering therapy (ULT), treatment gout flares, lifestyle other medication recommendations.Fifty-seven population, intervention, comparator, outcomes questions were developed, followed by a systematic literature review, network meta-analyses with ratings available evidence according to Grading Recommendations Assessment, Development Evaluation (GRADE) methodology, patient input. A group consensus...
Objective To provide guidance for the management of gout, including indications and optimal use urate‐lowering therapy ( ULT ), treatment gout flares, lifestyle other medication recommendations. Methods Fifty‐seven population, intervention, comparator, outcomes questions were developed, followed by a systematic literature review, network meta‐analyses with ratings available evidence according to Grading Recommendations Assessment, Development Evaluation GRADE ) methodology, patient input. A...
Despite current therapies, diffuse cutaneous systemic sclerosis (scleroderma) often has a devastating outcome. We compared myeloablative CD34+ selected autologous hematopoietic stem-cell transplantation with immunosuppression by means of 12 monthly infusions cyclophosphamide in patients scleroderma.
The Scleroderma Lung Study enrolled 158 patients with scleroderma-related interstitial lung disease in a placebo-controlled trial of oral cyclophosphamide (CYC). Although treatment-related benefits pulmonary function, skin scores, and patient-centered outcomes were demonstrated after 1 year therapy, the duration benefit beyond was unclear.A second follow-up performed to determine if these effects persisted stopping treatment.A detailed analysis data obtained over two years study...
Abstract Objective To evaluate CAT‐192, a recombinant human antibody that neutralizes transforming growth factor β1 (TGFβ1), in the treatment of early‐stage diffuse cutaneous systemic sclerosis (dcSSc). Methods Patients with SSc duration <18 months were randomly assigned to placebo group or 1 3 CAT‐192 groups: 10 mg/kg, 5 0.5 mg/kg. Infusions given on day 0 and weeks 6, 12, 18. The primary objective this study was safety, tolerability, pharmacokinetics CAT‐192. Secondary outcomes included...
The modified Rodnan skin score (mRSS) is a measure of thickness and used as primary or secondary outcome in clinical trials systemic sclerosis (scleroderma). This state-of-art review provides historical perspective the development mRSS, summarizes performance mRSS an measure, guidance on assessing makes recommendations for incorporation into trials.
Gout is a disorder that manifests as spectrum of clinical and pathologic features built on foundation an excess body burden uric acid, manifested in part by hyperuricemia.We developed two-part American College R h e u m t o l g y i d n s , r v f c prophylaxis, chronic management gout.The guidelines were using evidence consensus-based methodology.These are applicable for rheumatologists other health care providers, including subspecialists, primary practitioners, nurse physician assistants,...