A5042825023- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Spondyloarthritis Studies and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Biosimilars and Bioanalytical Methods
- Spine and Intervertebral Disc Pathology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Osteoarthritis Treatment and Mechanisms
- Studies on Chitinases and Chitosanases
- Bone health and treatments
- Musculoskeletal pain and rehabilitation
- Dermatologic Treatments and Research
- Bone health and osteoporosis research
- Monoclonal and Polyclonal Antibodies Research
- Bone and Joint Diseases
- Hip disorders and treatments
- Autoimmune Bullous Skin Diseases
- Chronic Lymphocytic Leukemia Research
- Hip and Femur Fractures
- Inflammatory Myopathies and Dermatomyositis
- IL-33, ST2, and ILC Pathways
- Mast cells and histamine
- Elbow and Forearm Trauma Treatment
Medical University Plovdiv
2016-2025
Plovdiv University
2018-2025
Dr. Reddy's Laboratories (India)
2024
Dr. Reddy's Laboratories (United States)
2024
Kaspe (Czechia)
2019-2020
Stamatopoulos and Associates (Greece)
2019
Center for Rheumatology
2013-2014
St. George's University
2013
To investigate the pharmacodynamics, pharmacokinetics and safety of cenerimod-a potent, oral, selective sphingosine 1-phosphate 1 receptor modulator-in patients with SLE.This multicentre, double-blind, placebo-controlled study was conducted in two parts. In part A, SLE were randomised 1:1:1:1 to receive oral cenerimod 0.5, or 2 mg, placebo once daily for 12 weeks. Following an interim review additional 3:1 B received 4 mg Endpoints included changes total lymphocyte count, Disease Activity...
Abstract Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease characterized by fibrosis of the skin and internal organs, autoimmunity-driven damage vasculopathy. The current approved disease-modifying treatments have limited efficacy, treatment guided toward alleviating organ complications. Thus, there an unmet need for discovering new effective options. There recent evidence that JAK/STAT signaling pathway markedly activated in SSc patients. To assess efficacy safety...
Namilumab (AMG203) is an immunoglobulin G1 monoclonal antibody that binds with high affinity to the GM-CSF ligand. This was a phase 1b, randomized, double-blind study (PRIORA) assess namilumab in active, mild-to-moderate rheumatoid arthritis (RA). The primary outcome safety and tolerability of repeated subcutaneous injections patients RA. Adults RA on stable methotrexate doses for ≥12 weeks were eligible. Patients received three 150 or 300 mg, placebo days 1, 15, 29, 12 weeks' follow-up....
Introduction Foot and ankle pain is a common problem in rheumatic patients. One often underrecognized cause of this complaint Gruberi (or subtalar) bursitis. The bursa structure that originates from the sinus tarsi extends over dorsal talar surface. It reduces friction extensor digitorum longus tendon convex contour head talus. On ultrasound, bursitis characterized by well-defined fluid collection dorsolateral foot, located between talus longus. Our study aimed to determine frequency...
Objectives: This study aimed to explore whether hand ultrasonography (USG) could differentiate between rheumatoid arthritis (RA) and psoriatic (PsA) patients. Patients methods: A comprehensive USG of 35 PsA patients (13 males, 22 females; mean age: 60.9±8.4 years; range, 53 69 years), 30 RA (10 20 58.4±10.0 50 61 healthy controls (5 15 55.6±5.8 years) was performed with assessments the wrist, tendons, mini-entheses, joints second third finger, both on gray scale power Doppler USG. Results:...
Rheumatoid arthritis (RA) is the most common inflammatory joint disease. Various proinflammatory cytokines are involved in pathogenesis of this chronic disorder. It characterized by presence autoantibodies, such as rheumatoid factor and antibodies against citrullinated peptides. The present study focuses on investigation possible association between cytokine interleukin 17 anti-CCP, anti-MCV, anti-CarP seropositivity RA patients.To assess serum levels (IL-17) patients with healthy controls...
Aim: To identify ultrasound (US) predictors of persistence or change in the diagnosis rheumatoid arthritis (RA) after five years a cohort patients with early RA. Patients and Methods: One hundred twenty who met 2010 ACR/EULAR classification criteria for RA were followed period years. The US assessment at baseline included bilateral evaluation wrists, second to fifth metacarpophalangeal (MCP) joints, proximal interphalangeal (PIP) IV VI extensor compartments flexor tendons fingers. This was...
Systemic sclerosis (SSc) is an autoimmune disease with completely undefined etiology and treatment difficulties. The expression of both protein coding non-coding RNAs dysregulated during development. We aimed to examine a possible regulatory axis implemented in the control chitinase-3 like 1 (CHI3L1) or YKL-40, inflammation-associated glycoprotein, shown be elevated SSc. A panel seven miRNAs three lncRNAs potentially involved CHI3L1 were selected on basis silico analysis. TagMan assay was...
Abstract Background: Rheumatoid arthritis (RA) causes chronic inflammation and alteration of articular tissue joints. The pathogenesis the disease remains unclear although it is known that proinflammatory cytokines play a major role in its induction. YKL-40 chitinase-like glycoprotein produced by activated macrophages, neutrophils, arthritic chondrocytes cancer cells. It has been shown implicated remodeling, angiogenesis inflammation. Aim: to investigate serum synovial levels relation IL-1β,...
ACHILLES aimed to demonstrate efficacy of secukinumab on Achilles' tendon enthesitis in spondyloarthritis (SpA) patients.
The aim of our study was to analyze the level glycoprotein YKL-40 in patients with active knee osteoarthritis (OA) and search possible correlations local inflammation ultrasound (US) findings.Material methods: A prospective fifty consecutive OA (diagnosed based on American College Rheumatology criteria for radiographic confirmation) performed. Concentrations serum synovial fluid were measured by ELISA. US examinations – Gray scale (GS) Power Doppler (PD) performed according international...
To find the correlations between parameters of iron homeostasis, inflammatory activity and autoimmune disorders in rheumatoid arthritis (RA).The present study included 114 patients with RA 42 healthy controls. We determined homeostasis: serum iron, total binding capacity (TIBC), ferritin soluble transferrin receptor (sTfR), activity: C-reactive protein (CRP), interleukin-6 (IL-6) prohepcidin, disorders: factor (RF), anti-cyclic citrullinated peptide (antiCCP) antibodies DAS 28.The levels...
Objective: To assess the effectiveness and safety of infliximab biosimilar, CT-P13, administered in a real-life setting to adult patients with active rheumatoid arthritis (RA) or ankylosing spondylitis (AS).Methods: This multi-center, non-interventional, observational study was conducted Bulgaria, Czech Republic, Romania. A total 151 severe RA (n = 81) AS 70) were enrolled treated CT-P13 for 24 weeks, according current medical recommendations. Effectiveness assessed using 4-item Disease...
<h3>Background</h3> While the treatment with intravenous (IV) CT-P13, an infliximab biosimilar, is effective and well tolerated, a new subcutaneous (SC) CT-P13 formulation (CT-P13 SC) developed to provide additional, more convenient options opportunity for self-injection. <h3>Objectives</h3> To find optimal dose of SC evaluate efficacy, PK safety over first 30 weeks in patients rheumatoid arthritis. <h3>Methods</h3> This study consists 1 cohort IV, 3 cohorts different doses injected...