A5050458041- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Gout, Hyperuricemia, Uric Acid
- Inflammasome and immune disorders
- Spondyloarthritis Studies and Treatments
- Lymphoma Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Systemic Sclerosis and Related Diseases
- Osteoarthritis Treatment and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Lymphocytic Leukemia Research
- Hepatitis C virus research
- Cytokine Signaling Pathways and Interactions
- Healthcare and Venom Research
- Monoclonal and Polyclonal Antibodies Research
- Ocular Diseases and Behçet’s Syndrome
- Inflammatory mediators and NSAID effects
- Salivary Gland Disorders and Functions
- Bone and Joint Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Immune Cell Function and Interaction
- Pharmaceutical studies and practices
- Psoriasis: Treatment and Pathogenesis
- Atherosclerosis and Cardiovascular Diseases
Catholic University of Daegu
2016-2025
Daegu Catholic University Medical Center
2015-2023
Center for Rheumatology
2020-2022
Weatherford College
2021
Chonnam National University Hospital
2017
Alba Graduate Business School, The American College of Greece
2014
St. Paul's Hospital
2013
Institute of Biomedical Science
2007
University of California, San Diego
2003
Objective To investigate baseline and change of pulmonary damage biomarkers (serum Krebs von den Lungen 6 [KL-6], human surfactant protein D [hSP-D], matrix metalloproteinase 7 [MMP-7]) with rheumatoid arthritis–associated interstitial lung disease (RA-ILD) progression. Methods In the Korean Rheumatoid Arthritis Interstitial Lung Disease (KORAIL) cohort, a prospective we enrolled patients RA ILD confirmed by chest computed tomography imaging followed annually. progression was defined as...
Inflammatory arthritis is associated with the release of a network key cytokines. In T cell receptor transgenic K/BxN mice interleukin (IL)-1 plays role in joint swelling and destruction, as suggested by ability anti–IL-1receptor (IL-1R) antibody treatment to delay onset slow progression this disease. This mechanism dependent on signaling pathway intermediary myeloid differentiation factor 88 (MyD88), such that neither IL-1R nor MyD88-deficient developed visually detectable synovitis after...
<h3>Objectives</h3> To compare the efficacy, safety, immunogenicity and pharmacokinetics (PK) of SB2 to infliximab reference product (INF) in patients with moderate severe rheumatoid arthritis (RA) despite methotrexate therapy. <h3>Methods</h3> This is a phase III, randomised, double-blind, multinational, multicentre parallel group study. Patients RA therapy were randomised 1:1 ratio receive either or INF 3 mg/kg. The primary end point was American College Rheumatology 20% (ACR20) response...
Efficacy, safety and immunogenicity results from the phase III study of SB2, a biosimilar reference infliximab (INF), were previously reported through 54 weeks. This transition period compared in patients with rheumatoid arthritis (RA) who switched INF to SB2 those maintained treatment or SB2.Patients moderate severe RA despite methotrexate randomised (1:1) receive at weeks 0, 2 6 every 8 thereafter until week 46. At 54, receiving rerandomised switch (INF/SB2 (n=94)) continue on (INF/INF...
<h3>Objective</h3> A highly polygenic aetiology and high degree of allele-sharing between ancestries have been well elucidated in genetic studies rheumatoid arthritis. Recently, the high-density genotyping array Immunochip for immune disease loci identified 14 new arthritis risk among individuals European ancestry. Here, we aimed to identify using Korean-specific data. <h3>Methods</h3> We analysed Korean case–control samples genome-wide association (GWAS) search alleles with...
Abstract Background The impact of sarcopenia on clinical outcomes coronavirus disease 2019 (COVID-19) is not clearly determined yet. We aimed to investigate the association between baseline and in patients with COVID-19. Methods All hospitalized adult COVID-19 who had chest computed tomography (CT) scans at a Korean university hospital from February 2020 May were included. main outcome was time admission discharge. Death considered as competing risk for Baseline skeletal muscle...
To explore the course of lung function and RA disease activity predictive factors for deteriorating in patients with RA-interstitial (ILD).The Korean Rheumatoid Arthritis-Interstitial Lung Disease cohort is a multicentre, prospective observational cohort. Patients RA-ILD were enrolled followed up annually 3 years ILD status assessment. Group-based modelling was used to cluster similar predicted percentage forced vital capacity (FVC%) patterns into trajectories.This study included 140 who...
Objective To investigate the risk of cardiovascular disease (CVD) associated with increasing dose a non-steroidal anti-inflammatory drug (NSAID) in patients ankylosing spondylitis (AS). Methods Using Korean National Health Insurance database, newly diagnosed AS without prior CVD between 2010 and 2018 were included this nationwide cohort study. The primary outcome was CVD, composite ischaemic heart disease, stroke or congestive failure. Exposure to NSAIDs evaluated using time-varying...
It has been suggested that hyperuricemia and possibly gout are associated with the metabolic syndrome, but there have no direct studies. This study was undertaken to obtain prevalence of syndrome in patients compare it those from general population a 4-institutional case-historical control composed 168 gout. We assessed according ATP III criteria compared historical controls. To elucidate factors were multivariate analysis done. The age-adjusted 43.6%, which significantly higher than Korean...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder whose etiology incompletely understood, but likely involves environmental triggers in genetically susceptible individuals. Using an unbiased genome-wide association (GWA) scan and replication analysis, we sought to identify the genetic loci associated with SLE Korean population.
Recent reports have associated NCF2, encoding a core component of the multi-protein NADPH oxidase (NADPHO), with systemic lupus erythematosus (SLE) susceptibility in individuals European ancestry. To identify ethnicity-specific and -robust variants within we assessed 145 SNPs around NCF2 gene 5325 cases 21 866 controls European-American (EA), African-American (AA), Hispanic (HS) Korean (KR) Subsequent imputation, conditional, haplotype bioinformatic analyses identified seven potentially...
Objective To demonstrate pharmacokinetic equivalence of CT-P10 and innovator rituximab (RTX) in patients with rheumatoid arthritis (RA) inadequate responses or intolerances to antitumour necrosis factor agents. Methods In this randomised phase I trial, active RA were randomly assigned (2:1) receive 1000 mg RTX at weeks 0 2 (alongside continued methotrexate therapy). Primary endpoints area under the serum concentration–time curve from time zero last quantifiable concentration (AUC 0–last )...
Objective. Evidence for the role of autophagy in regulation inflammation, especially IL-1β expression response to monosodium urate (MSU) crystals, is presented. This study investigated p62, a selective receptor autophagy, production MSU crystal-induced inflammation. Methods. IL-1β, TNF-α and IL-6 mRNA was measured by quantitative real-time PCR (qRT-PCR). Autophagy-related molecules such as Cullin-3, microtubule-associated protein 1 light-chain 3 (LC3) I/II, ubiquitin, caspase-1...
Background and Objectives: Hematological indices have been known to be available markers used for evaluating disease activity in rheumatoid arthritis (RA). This study serves verify the association between four different hematological measures patients with RA. Materials Methods: The included 257 female RA 71 age-matched controls. Four indices, namely systemic immune-inflammation index (SII), neutrophil-to-hemoglobin lymphocyte (NHL) score, neutrophil-to-lymphocyte ratio (NLR),...