Christopher J. Lessard
A5072153652- Salivary Gland Disorders and Functions
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Atherosclerosis and Cardiovascular Diseases
- Galectins and Cancer Biology
- NF-κB Signaling Pathways
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Growth Hormone and Insulin-like Growth Factors
- Inflammasome and immune disorders
- Ocular Surface and Contact Lens
- Cytokine Signaling Pathways and Interactions
- Chemokine receptors and signaling
- Chronic Lymphocytic Leukemia Research
- Systemic Sclerosis and Related Diseases
- Cell Adhesion Molecules Research
- interferon and immune responses
- Protein Tyrosine Phosphatases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Oklahoma Medical Research Foundation
2016-2025
University of Oklahoma Health Sciences Center
2014-2025
Karolinska Institutet
2023
Johnson & Johnson (United States)
2023
Janssen (United States)
2023
Human Gene Therapy Research Institute
2023
Oklahoma City University
2023
Stavanger University Hospital
2018-2023
Medical University of South Carolina
2021
University of Oklahoma
2009-2019
<h3>Abstract</h3> <h3>Objective</h3> To compare the performance of American–European Consensus Group (AECG) and newly proposed American College Rheumatology (ACR) classification criteria for Sjögren9s Syndrome (SS) in a well-characterised sicca cohort, given ongoing efforts to resolve discrepancies weaknesses systems. <h3>Methods</h3> In multidisciplinary clinic evaluation sicca, we assessed features salivary lacrimal gland dysfunction autoimmunity as defined by tests both AECG ACR 646...
Objective More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts this, and we undertook study to test our hypothesis trisomy (47,XXX; occurring in ∼1 1,000 live births) would be increased patients with female‐predominant diseases (systemic lupus erythematosus [SLE], primary Sjögren's syndrome [SS], biliary cirrhosis, rheumatoid arthritis [RA]) compared without...
Sarcoidosis is a systemic inflammatory disease characterized by the formation of granulomas in affected organs. Genome-wide association studies (GWASs) this have been conducted only European population. We present first sarcoidosis GWAS African Americans (AAs, 818 cases and 1,088 related controls) followed replication independent sets AAs (455 557 (EAs, 442 2,284 controls). evaluated >6 million SNPs either genotyped using Illumina Omni1-Quad array or imputed from 1000 Genomes Project data....
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by lymphocytic exocrinopathy. However, patients often have evidence of systemic autoimmunity, and they are at markedly increased risk for the development non- Hodgkin's lymphoma. Similar to other disorders, strong interferon (IFN) signature present among subsets pSS patients, although precise etiology remains uncertain. NCR3/NKp30 natural killer (NK)-specific activating receptor regulating cross talk between NK...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder whose etiology incompletely understood, but likely involves environmental triggers in genetically susceptible individuals. Using an unbiased genome-wide association (GWA) scan and replication analysis, we sought to identify the genetic loci associated with SLE Korean population.
Type I interferon (IFN-I) and T helper 17 (TH17) drive pathology in neuromyelitis optica spectrum disorder (NMOSD) TH17-induced experimental autoimmune encephalomyelitis (TH17-EAE). This is paradoxical because the prevalent theory that IFN-I inhibits TH17 function. Here we report a cascade involving IFN-I, IL-6 B cells promotes TH17-mediated neuro-autoimmunity. In NMOSD, elevated signatures, IL-17 are associated with severe disability. Furthermore, levels lower patients on anti-CD20 therapy....
Abstract Sjögren’s disease is a complex autoimmune with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel significant (GWS) regions in cases of European ancestry: CD247 , NAB1 PTTG1-MIR146A PRDM1-ATG5 TNFAIP3 XKR6 MAPT- CRHR1 RPTOR-CHMP6-BAIAP6 TYK2 SYNGR1 . Polygenic risk scores yield predictability (AUROC = 0.71) and relative 12.08. Interrogation bioinformatics databases refine the associations, define local regulatory networks GWS SNPs...
Exploiting genotyping, DNA sequencing, imputation and trans-ancestral mapping, we used Bayesian frequentist approaches to model the IRF5–TNPO3 locus association, now implicated in two immunotherapies seven autoimmune diseases. Specifically, systemic lupus erythematosus (SLE), resolved separate associations IRF5 promoter (all ancestries) with an extended European haplotype. We captured 3230 high-quality, common variants across 5 ethnicities 8395 SLE cases 7367 controls. The genetic effect...
Abstract Objective Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production and altered type I interferon expression. Genetic surveys genome‐wide association studies have identified >30 SLE susceptibility genes. One of these genes, TNIP1 , encodes the ABIN1 protein. functions in immune system restricting NF‐κB signaling. The present study was undertaken to investigate genetic factors that influence with genes regulate pathway. Methods We...
Sjögren's syndrome (SS) is a common, autoimmune exocrinopathy distinguished by keratoconjunctivitis sicca and xerostomia. Patients frequently develop serious complications including lymphoma, pulmonary dysfunction, neuropathy, vasculitis, debilitating fatigue. Dysregulation of type I interferon (IFN) pathway prominent feature SS correlated with increased autoantibody titers disease severity. To identify genetic determinants IFN dysregulation in SS, we performed cis-expression quantitative...