A5055196283- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Salivary Gland Disorders and Functions
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Rheumatoid Arthritis Research and Therapies
- Diabetes and associated disorders
- Genetic Associations and Epidemiology
- NF-κB Signaling Pathways
- RNA Research and Splicing
- Galectins and Cancer Biology
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Immunology Research
- Blood Coagulation and Thrombosis Mechanisms
- RNA modifications and cancer
- Chemokine receptors and signaling
- Systemic Sclerosis and Related Diseases
- Genomics and Rare Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Genetic factors in colorectal cancer
University of California, San Francisco
2015-2024
National Human Genome Research Institute
2024
South Australian Health and Medical Research Institute
2023-2024
Health Research Alliance
2023-2024
Vancouver Island University
2018
City College of San Francisco
2016-2017
Mayo Clinic
2011
WinnMed
2011
Fisheries and Oceans Canada
2004
University of Liverpool
1995
Patients with chronic inflammatory disease (CID) treated immunosuppressive medications have increased risk for severe COVID-19. Although mRNA-based SARS-CoV-2 vaccination provides protection in immunocompetent persons, immunogenicity immunosuppressed patients CID is unclear.To determine the of vaccines CID.Prospective observational cohort study.Two U.S. referral centers.Volunteer sample adults confirmed eligible early COVID-19 vaccination, including hospital employees any age and older than...
ABSTRACT Background Individuals with chronic inflammatory diseases (CID) are frequently treated immunosuppressive medications that can increase their risk of severe COVID-19. While novel mRNA-based SARS-CoV-2 vaccination platforms provide robust protection in immunocompetent individuals, the immunogenicity CID patients on immunosuppression is not well established. Therefore, determining effectiveness vaccines setting essential to risk-stratify impaired and clinical guidance regarding...
Systemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. A polymorphism in the STAT4 gene has recently been established as risk factor for SLE, but relationship specific SLE subphenotypes not studied. We studied 137 SNPs region genotyped 4 independent case series (total n = 1398) and 2560 healthy controls, along data cases. Using conditional testing, we confirmed most significant haplotype risk. then SNP marking this association...
Systemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. Recent studies have greatly expanded the number of established SLE risk alleles, but distribution multiple alleles in cases versus controls and their relationship to subphenotypes not been studied. We studied 22 susceptibility polymorphisms previous genome-wide evidence association (p < 5 x 10⁻¹²⁸) 1919 from 9 independent Caucasian case series 4813 controls. The mean was 15.1 (SD...
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by lymphocytic exocrinopathy. However, patients often have evidence of systemic autoimmunity, and they are at markedly increased risk for the development non- Hodgkin's lymphoma. Similar to other disorders, strong interferon (IFN) signature present among subsets pSS patients, although precise etiology remains uncertain. NCR3/NKp30 natural killer (NK)-specific activating receptor regulating cross talk between NK...
Objective The Sjögren's International Collaborative Clinical Alliance (SICCA) is an international data registry and biorepository derived from a multisite observational study of participants in whom genotyping was performed on the Omni2.5M platform who had undergone deep phenotyping using common protocol‐directed methods. aim this to examine genetic etiology syndrome (SS) across ancestry disease subsets. Methods We genome‐wide association analyses SICCA subjects external controls obtained...
Abstract Sjögren’s disease is a complex autoimmune with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel significant (GWS) regions in cases of European ancestry: CD247 , NAB1 PTTG1-MIR146A PRDM1-ATG5 TNFAIP3 XKR6 MAPT- CRHR1 RPTOR-CHMP6-BAIAP6 TYK2 SYNGR1 . Polygenic risk scores yield predictability (AUROC = 0.71) and relative 12.08. Interrogation bioinformatics databases refine the associations, define local regulatory networks GWS SNPs...
A substantial genetic contribution to systemic lupus erythematosus (SLE) risk is conferred by major histocompatibility complex (MHC) gene(s) on chromosome 6p21. Previous studies in SLE have lacked statistical power and resolution fully define MHC influences. We characterized 1,610 Caucasian cases 1,470 parents for 1,974 SNPs, the highly polymorphic HLA-DRB1 locus, a panel of ancestry informative markers. Single-marker analyses revealed strong signals SNPs within several regions, as well with...
Abstract Background Chromosomal complement, including that provided by the sex chromosomes, influences expression of proteins and molecular signaling in every cell. However, less than 50% scientific studies published 2009 using experimental animals reported as a biological variable. Because cell has sex, we conducted literature review to determine extent which is variable cardiovascular on cultured cells. Methods Articles from 10 journals with high impact factors ( Circulation , J Am Coll...
Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies associated with specific clinical manifestations. Previous studies have shown an association between differential DNA methylation and SLE susceptibility, but not investigated SLE-related autoantibodies. Our goal was to determine whether production clinically relevant autoantibodies, emphasis on anti-dsDNA autoantibody. In this study, we status 467,314 CpG sites in 326 women SLE. Using a discovery...
Sjögren's syndrome (SS) is a complex multisystem autoimmune disease that results in progressive destruction of the exocrine glands. The purpose this study was to characterize epigenetic changes affected gland tissue and describe relationship these known inflammatory processes.A genome-wide DNA methylation performed on human labial salivary (LSG) biopsy samples obtained from 28 female members International Collaborative Clinical Alliance (SICCA) Registry. Gland methylotyped using Illumina...
African Americans, East Asians, and Hispanics with systemic lupus erythematous (SLE) are more likely to develop nephritis (LN) than SLE patients of European descent. The etiology this difference is not clear, study was undertaken investigate how genetic variants might explain effect.In cross-sectional study, 1244 from multiethnic case collections were genotyped for 817,810 single-nucleotide polymorphisms (SNPs) across the genome. Continental ancestry estimated utilizing program ADMIXTURE....
Systemic lupus erythematous (SLE) is a heterogeneous autoimmune disease in which outcomes vary among different racial groups. Here, we aim to identify SLE subgroups within multiethnic cohort using an unsupervised clustering approach based on the American College of Rheumatology (ACR) classification criteria. We three patient clusters that according severity. Methylation association analysis identifies set 256 differentially methylated CpGs across clusters, including 101 genes Type I...
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease in which outcomes vary among different racial groups. We leverage cell-sorted RNA-seq data (CD14+ monocytes, B cells, CD4+ T and NK cells) from 120 SLE patients (63 Asian 57 White individuals) apply a four-tier approach including unsupervised clustering, differential expression analyses, gene co-expression machine learning to identify subgroups within this multiethnic cohort. K-means clustering on each cell-type resulted...
Abstract Objective African Americans, East Asians, and Hispanics with systemic lupus erythematosus (SLE) are more likely to develop renal disease than SLE patients of European descent. This study was undertaken investigate whether genetic ancestry protects against the development nephritis, aim exploring socioeconomic factors that might explain this effect. Methods a cross‐sectional from multiethnic case collection. Participants were genotyped for 126 single‐nucleotide polymorphisms (SNPs)...
Objectives Patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) have increased risk of cardiovascular disease (CVD). We investigated whether single nucleotide polymorphisms (SNPs) at autoimmunity loci were associated CVD in SLE RA. Methods (n=1045) genotyped using the 200K Immunochip SNP array (Illumina). The allele frequency was compared between patients without different manifestations CVD. Results replicated a second cohort (n=1043) an RA (n=824). analysed...
The Probabilistic Identification of Causal SNPs (PICS) algorithm and web application was developed as a fine-mapping tool to determine the likelihood that each single nucleotide polymorphism (SNP) in LD with reported index SNP is true causal polymorphism. PICS notable for its ability identify candidate within locus using only SNP, which are widely available from published GWAS, whereas other methods require full summary statistics or genotype data. However, original operates on at time, slow...