Joel M. Guthridge
A5032779152- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Salivary Gland Disorders and Functions
- interferon and immune responses
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Cytomegalovirus and herpesvirus research
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Galectins and Cancer Biology
- Protein Tyrosine Phosphatases
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Viral-associated cancers and disorders
- Systemic Sclerosis and Related Diseases
- SARS-CoV-2 and COVID-19 Research
Oklahoma Medical Research Foundation
2016-2025
University of Oklahoma Health Sciences Center
2015-2024
University of Oklahoma
2023
Stavanger University Hospital
2023
Karolinska Institutet
2023
Johnson & Johnson (United States)
2023
Janssen (United States)
2023
Johns Hopkins University
2023
Sapienza University of Rome
2023
Weizmann Institute of Science
2023
The antiphospholipid syndrome (APS) is characterized by recurrent fetal loss, vascular thrombosis, and thrombocytopenia occurring in the presence of (aPL) antibodies. pathogenesis loss tissue injury APS incompletely understood, but thought to involve platelet endothelial cell activation as well procoagulant effects aPL antibodies acting directly on clotting pathway components. Recent studies have shown that uncontrolled complement placenta leads death utero. We hypothesized activate...
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals European (EA), African (AA) Hispanic Amerindian (HA) ancestry. identify 58 distinct non-HLA regions in EA, 9 AA 16 HA (∼50% these have multiple independent associations); include 24 novel (P<5 × 10-8), refined signals established regions, extended associations to additional...
Systemic lupus erythematosus (SLE) is a multisystem, autoimmune disease that predominantly affects women. Previous findings duplicated Toll-like receptor 7 ( Tlr7 ) promotes lupus-like in male BXSB mice prompted us to evaluate TLR7 human SLE. By using candidate gene approach, we identified and replicated association of 3′UTR SNP, rs3853839 (G/C), with SLE 9,274 Eastern Asians P combined = 6.5 × 10 −10 ), stronger effect than female subjects [odds ratio, vs. 2.33 (95% CI 1.64–3.30) 1.24...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathologic T cell-B cell interactions and autoantibody production. Defining the populations that drive B responses in SLE may enable design of therapies specifically target subsets. Here, we evaluated phenotypes CD4+ cells circulation 52 patients drawn from multiple cohorts identified a highly expanded PD-1hiCXCR5-CD4+ population. Cytometric, transcriptomic, functional assays demonstrated are peripheral helper (Tph)...
The relationship of immune dysregulation and autoantibody production that may contribute to systemic lupus erythematosus (SLE) pathogenesis is unknown. This study evaluates the individual combined contributions autoantibodies, type I interferon (IFN-α) activity, IFN-associated soluble mediators disease development leading SLE.Serial serum specimens from 55 individuals collected prior SLE classification (average timespan=4.3 years) unaffected healthy controls matched by age (±5 years),...
It has been presumed that rheumatoid arthritis (RA) joint pain is related to inflammation in the synovium; however, recent studies reveal scores patients do not correlate with synovial inflammation. We developed a machine-learning approach (graph-based gene expression module identification or GbGMI) identify an 815-gene associated biopsy samples from established RA who had limited at arthroplasty. then validated this finding independent cohort of early untreated little Single-cell RNA...
Lupus nephritis (LN) is a pathologically heterogenous autoimmune disease linked to end-stage kidney and mortality. Better therapeutic strategies are needed as only 30%-40% of patients completely respond treatment. Noninvasive biomarkers intrarenal inflammation may guide more precise approaches. Because urine collects the byproducts inflammation, we studied proteomic profiles 225 with LN (573 samples) in longitudinal Accelerating Medicines Partnership RA/SLE cohort. Urinary...
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system's own record antigen exposures encoded by receptors on B cells T cells. We analyzed receptor datasets from 593 individuals to develop MAchine Learning for Immunological Diagnosis, an interpretive framework screen multiple illnesses simultaneously or precisely test one condition. This approach detects specific...
Vitamin D deficiency is widespread and has been associated with many chronic diseases, including autoimmune disorders. A study was undertaken to explore the impact of low vitamin levels on autoantibody production in healthy individuals, as well B cell hyperactivity interferon α (IFNα) activity patients systemic lupus erythematosus (SLE).
Systemic lupus erythematosus (SLE), a complex polygenic autoimmune disease, is associated with increased complement activation. Variants of genes encoding regulator factor H (CFH) and five CFH-related proteins (CFHR1-CFHR5) within the chromosome 1q32 locus linked to SLE, have been multiple human diseases may contribute dysregulated activation predisposing SLE. We assessed 60 SNPs covering CFH-CFHRs region for association SLE in 15,864 case-control subjects derived from four ethnic groups....
MicroRNAs (miRNA) have emerged as an important new class of modulators gene expression. In this study we investigated miRNA that are differentially expressed in lupus nephritis. Microarray technology was used to investigate peripheral blood mononuclear cells (PBMCs) and Epstein-Barr Virus (EBV)-transformed cell lines obtained from nephritis affected patients unaffected controls. TaqMan-based stem-loop real-time polymerase chain reaction for validation. analysis both African American (AA)...
Objective More than 80% of autoimmune disease predominantly affects females, but the mechanism for this female bias is poorly understood. We suspected that an X chromosome dose effect accounts this, and we undertook study to test our hypothesis trisomy (47,XXX; occurring in ∼1 1,000 live births) would be increased patients with female‐predominant diseases (systemic lupus erythematosus [SLE], primary Sjögren's syndrome [SS], biliary cirrhosis, rheumatoid arthritis [RA]) compared without...
A previous genome-wide association study conducted in a population of European ancestry identified rs4963128, KIAA1542 single-nucleotide polymorphism (SNP) 23 kb telomeric to IRF7 (the gene for interferon regulatory factor 7 [IRF-7]), be strongly associated with systemic lupus erythematosus (SLE). This was undertaken investigate whether genetic within is risk the development SLE.We genotyped one SNP (rs4963128) and (rs1131665 [Q412R]) an Asian (1,302 cases, 1,479 controls), assess their SLE....