John Bowes
A5020187396- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Lymphoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Genetic Associations and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Spondyloarthritis Studies and Treatments
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Adolescent and Pediatric Healthcare
- Diabetes and associated disorders
- Celiac Disease Research and Management
- NF-κB Signaling Pathways
- Viral Infections and Immunology Research
- Protein Tyrosine Phosphatases
- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Inflammatory Myopathies and Dermatomyositis
- IL-33, ST2, and ILC Pathways
Genomics (United Kingdom)
2016-2025
Manchester University NHS Foundation Trust
2019-2025
Manchester Academic Health Science Centre
2016-2025
NIHR Manchester Biomedical Research Centre
2013-2025
Versus Arthritis
2015-2025
University of Manchester
2016-2025
NIHR Oxford Musculoskeletal Biomedical Research Centre
2016-2025
University Hospital of Zurich
2023
University of Zurich
2023
University of Bern
2023
Nature Communications 6: Article number: 6046 (2015); Published 5 February 2015; Updated 6 July 2015 The affiliation details for Emiliano Giardina are incorrect in this Article. correct address author is given below: Department of Biopathology, Centre Excellence Genomic Risk Assessment Multifactorial and Complex Diseases, School Medicine, University Rome 'Tor Vergata' Laboratory Molecular Genetics UILDM, Fondazione Santa Lucia, 00179, Italy.
Lipid pathways have been implicated in the pathogenesis of psoriasis, and some lipid-lowering drugs, such as statins, are hypothesized to disease-modifying properties. However, large population-level studies scarce, causal interpretation results from traditional observational designs is limited by confounding.
Abstract Objective In the era of postgenomic research, linkage‐ and association‐based strategies are beginning to reveal novel complex disease genes. Using such an approach, a functional haplotype peptidylarginine deiminase 4 gene ( PADI4 ) has recently been identified as conferring susceptibility rheumatoid arthritis (RA) in Japanese population. present study, we investigated association single‐nucleotide polymorphisms (SNPs) with RA UK Methods Association exonic SNPs (padi4_89*G/A,...
Abstract Psoriatic arthritis (PsA) is a chronic inflammatory associated with psoriasis and, despite the larger estimated heritability for PsA, majority of genetic susceptibility loci identified to date are shared psoriasis. Here, we present results from case–control association study on 1,962 PsA patients and 8,923 controls using Immunochip genotyping array. We identify eight passing genome-wide significance, secondary independent effects at three distinct PsA-specific variant IL23R locus....
Rheumatoid arthritis (RA) is an archetypal, common, complex autoimmune disease with both genetic and environmental contributions to aetiology. Two novel RA susceptibility loci have been reported from recent genome-wide candidate gene association studies. We, therefore, investigated the evidence for of STAT4 TRAF1/C5 using imputed data Wellcome Trust Case Control Consortium (WTCCC). No variants mapping was detected in 1860 cases 2930 control samples tested that study. Variants did show...
The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes interstitial lung disease. We genotyped 2566 IIM cases Caucasian descent using the Immunochip; custom array covering 186 established susceptibility loci. cohort was predominantly comprised patients with dermatomyositis (DM, n=879), juvenile DM (JDM, n=481), polymyositis (PM, n=931) inclusion body myositis...
Background Evidence is beginning to emerge that there may be susceptibility loci for rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are common both diseases. Objective To investigate single nucleotide polymorphisms have been reported associated with SLE in a UK cohort of patients RA controls. Methods 3962 9275 controls were included the study. Eleven SNPs mapping confirmed investigated. These mapped TNFSF4 , BANK1 TNIP1 PTTG1 UHRF1BP1 ATG5 JAZF1 BLK KIAA1542 ITGAM UBE2L3...
Despite the success of genome-wide association studies (GWAS) in detecting a large number loci for complex phenotypes such as rheumatoid arthritis (RA) susceptibility, lack information on causal genes leaves important challenges to interpret GWAS results context disease biology. Here, we genetically fine-map RA risk locus at 19p13 define variants, and explore pleiotropic effects these same variants other traits. First, combined Immunochip dense genotyping (n = 23,092 case/control samples),...
<h3>Objectives</h3> To investigate a shared genetic aetiology for skin involvement in psoriasis and psoriatic arthritis (PsA) by genotyping single-nucleotide polymorphisms (SNPs), reported to be associated genome-wide association studies of psoriasis, patients with PsA. <h3>Methods</h3> SNPs evidence were genotyped PsA case control collection from the UK Ireland. Genotype allele frequencies compared between cases controls using Armitage test trend. <h3>Results</h3> Seven mapping IL1RN,...
<h3>Objective</h3> A highly polygenic aetiology and high degree of allele-sharing between ancestries have been well elucidated in genetic studies rheumatoid arthritis. Recently, the high-density genotyping array Immunochip for immune disease loci identified 14 new arthritis risk among individuals European ancestry. Here, we aimed to identify using Korean-specific data. <h3>Methods</h3> We analysed Korean case–control samples genome-wide association (GWAS) search alleles with...