A5068226078- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Pain Management and Opioid Use
- Genetic Associations and Epidemiology
- Psoriasis: Treatment and Pathogenesis
- Opioid Use Disorder Treatment
- Migraine and Headache Studies
- Retinal Diseases and Treatments
- COVID-19 Clinical Research Studies
- Hereditary Neurological Disorders
- Advanced Glycation End Products research
- Rheumatoid Arthritis Research and Therapies
- Dermatology and Skin Diseases
- Spine and Intervertebral Disc Pathology
- COVID-19 and healthcare impacts
- Cytokine Signaling Pathways and Interactions
- Retinal Imaging and Analysis
- Autoimmune and Inflammatory Disorders Research
- Anesthesia and Pain Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Medical Research and Practices
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Hip disorders and treatments
Ninewells Hospital
2016-2025
University of Dundee
2016-2025
Genomics (United Kingdom)
2013-2025
Huazhong University of Science and Technology
2021
Tongji Hospital
2021
Institute of Population and Public Health
2017
University of Manchester
2011-2016
Salford Royal NHS Foundation Trust
2013-2016
Manchester Academic Health Science Centre
2011-2016
University of Rome Tor Vergata
2015
Abstract Psoriatic arthritis (PsA) is a chronic inflammatory associated with psoriasis and, despite the larger estimated heritability for PsA, majority of genetic susceptibility loci identified to date are shared psoriasis. Here, we present results from case–control association study on 1,962 PsA patients and 8,923 controls using Immunochip genotyping array. We identify eight passing genome-wide significance, secondary independent effects at three distinct PsA-specific variant IL23R locus....
1. Introduction According to the International Diabetes Federation, diabetes mellitus (DM) is estimated affect around 415 million adults worldwide, roughly 8.8% of adult population, with figure projected rise over 600 by 2040.20 Regional prevalence varies from 3.2% in Africa 12.9% North America. associated a number chronic sequelae and 50% people DM go on develop polyneuropathy.35 This condition has variety clinical manifestations, which are grouped into positive symptoms including...
Abstract Introduction: Previous epidemiological studies of neuropathic pain have reported a range prevalences and factors associated with the disorder. Objectives: This study aimed to verify these characteristics in large UK cohort. Methods: A cross-sectional analysis was conducted 148,828 Biobank participants who completed detailed questionnaire on chronic pain. The Douleur Neuropathique en Quatre Questions (DN4) used distinguish between (NeuP) non-neuropathic (non-NeuP) at least 3 months'...
Abstract Background To improve the treatment of painful Diabetic Peripheral Neuropathy (DPN) and associated co-morbidities, a better understanding pathophysiology risk factors for DPN is required. Using harmonised cohorts (N = 1230) we have built models that classify versus painless using quality life (EQ5D), lifestyle (smoking, alcohol consumption), demographics (age, gender), personality psychology traits (anxiety, depression, traits), biochemical (HbA1c) clinical variables (BMI, hospital...
Headache is the most common neurological symptom and a leading cause of years lived with disability. We sought to identify genetic variants associated broadly-defined headache phenotype in 223,773 subjects from UK Biobank cohort.We defined based on specific question answered by participants. performed genome-wide association study as single entity, using 74,461 cases 149,312 controls.We identified 3343 SNPs which reached significance level P<5×10-8. The were located 28 loci, top SNP...
Division of Population Health and Genomics, School Medicine, University Dundee, Scotland *Corresponding author. Address: Mackenzie Building, Ninewells Hospital Medical School, Kirsty Semple Way, Dundee DD2 4BF, Scotland. Tel.: +44 1382 383795. E-mail address: [email protected] (B.H. Smith). Sponsorships or competing interests that may be relevant to content are disclosed at the end this article.
Abstract Purpose Diabetic retinopathy is the most common eye complication in patients with diabetes. The purpose of this study to identify genetic factors contributing severe diabetic retinopathy. Methods A genome‐wide association approach was applied. In Genetics Diabetes Audit and Research Tayside Scotland (Go DARTS ) datasets, cases were defined as type 2 who ever graded having background (Level R3) or proliferative R4) at least one according Scottish Retinopathy Grading Scheme once...
Hip pain is a common musculoskeletal complaint that leads many people to seek medical attention. We conducted primary genome-wide association study (GWAS) on the hip phenotype within UK Biobank cohort. Sex-stratified GWAS analysis approach was also performed explore sex specific variants associated with pain. found seven different loci at significance level, most significant single nucleotide polymorphism (SNP) being rs77641763 EXD3 (p value = 2.20 × 10–13). utilized summary statistics from...
Abstract Background Common types of musculoskeletal conditions include pain in the neck and shoulder areas. This study seeks to identify genetic variants associated with or based on a genome-wide association approach using 203 309 subjects from UK Biobank cohort look for replication evidence Generation Scotland: Scottish Family Health Study (GS:SFHS) TwinsUK. Methods A was performed adjusting age, sex, BMI nine population principal components. Significant independent were then sent GS:SFHS...
Family studies have provided overwhelming evidence for an underlying genetic component to psoriasis. Toll-like receptors (TLRs) are key transmembrane proteins in both the innate and adaptive immune responses which known be integral processes Recent functional support this notion having suggested a role TLR4 pathogenesis of Furthermore missense polymorphism gene has been associated with number autoimmune conditions, including Crohn diseases, making viable candidate investigation. The aim...
Background Diabetic foot ulcers (DFUs) are a devastating complication of diabetes. Objectives To identify genetic contributors to the development DFUs in presence peripheral neuropathy Scottish cohort with diabetes using genome‐wide association study. Methods A approach was applied. case defined as person (type 1 or type 2) who had ever ulcer (current previous) at least one foot, well positive monofilament test result (i.e. evidence neuropathy) recorded their longitudinal e‐health records....
<ns4:p><ns4:bold>Background: </ns4:bold>Neuropathic pain is an increasingly prevalent condition and has a major impact on health quality of life. However, the risk factors for development maintenance neuropathic are poorly understood. Clinical, genetic psychosocial all contribute to chronic pain, but their interactions have not been studied in large cohorts. The DOLORisk study aims these factors.</ns4:p><ns4:p> <ns4:bold>Protocol: </ns4:bold>Multicentre cross-sectional longitudinal cohorts...
Neuropathic pain is an increasingly prevalent condition and has a major impact on health quality of life. However, the risk factors for development maintenance neuropathic are poorly understood. Clinical, genetic psychosocial all contribute to chronic pain, but their interactions have not been studied in large cohorts. The DOLORisk study aims these factors.
Abstract We aimed to investigate the genetic associations of neuropathic pain in a deeply phenotyped cohort. Participants with were cases and compared those exposed injury or disease but without as control subjects. Diabetic polyneuropathy was most common aetiology pain. A standardised quantitative sensory testing protocol used categorize participants based on profile. performed genome-wide association study, subset participants, we undertook whole-exome sequencing targeting analyses 45...