Archie Campbell
A5032232791- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Health disparities and outcomes
- Metabolomics and Mass Spectrometry Studies
- Genetic Syndromes and Imprinting
- Intergenerational Family Dynamics and Caregiving
- COVID-19 and Mental Health
- RNA modifications and cancer
- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Genomics and Rare Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Cognitive Abilities and Testing
- Bioinformatics and Genomic Networks
- Genetic and phenotypic traits in livestock
- Liver Disease Diagnosis and Treatment
- Chronic Disease Management Strategies
- Genetics and Neurodevelopmental Disorders
- SARS-CoV-2 and COVID-19 Research
- GDF15 and Related Biomarkers
- Cancer-related molecular mechanisms research
- Tryptophan and brain disorders
- Alcohol Consumption and Health Effects
Western General Hospital
2016-2025
Edinburgh Cancer Research
2016-2025
University of Edinburgh
2016-2025
University of Cambridge
2024
The University of Queensland
2015-2023
Health Data Research UK
2021-2023
University of Glasgow
2015-2023
Population Health Research Institute
2023
Institute of Genetics and Cancer
2014-2021
Royal Edinburgh Hospital
2015-2021
Genetic testing for breast cancer susceptibility is widely used, but many genes, evidence of an association with weak, underlying risk estimates are imprecise, and reliable subtype-specific lacking.
The COVID-19 pandemic is an unprecedented global challenge, and point-of-care diagnostic classifiers are urgently required. Here, we present a platform for ultra-high-throughput serum plasma proteomics that builds on ISO13485 standardization to facilitate simple implementation in regulated clinical laboratories. Our low-cost workflow handles up 180 samples per day, enables high precision quantification, reduces batch effects large-scale longitudinal studies. We use our collected from cohort...
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes
Abstract We conduct a genome-wide association study (GWAS) of educational attainment (EA) in sample ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A polygenic predictor, or index (PGI), explains 12–16% EA variance contributes to risk prediction for ten diseases. Direct effects (i.e., controlling parental PGIs) explain roughly half the PGI’s magnitude with other phenotypes. The correlation between mate-pair...
Background The COVID-19 pandemic and mitigation measures are likely to have a marked effect on mental health. It is important use longitudinal data improve inferences. Aims To quantify the prevalence of depression, anxiety well-being before during pandemic. Also, identify groups at risk depression and/or Method Data were from Avon Longitudinal Study Parents Children (ALSPAC) index generation ( n = 2850, mean age 28 years) parent 3720, 59 years), Generation Scotland 4233, years). Depression...
Summary GS:SFHS is a family-based genetic epidemiology study with DNA and socio-demographic clinical data from about 24 000 volunteers across Scotland aged 18–98 years, February 2006 to March 2011. Biological samples anonymized form resource for research on the genetics of health, disease quantitative traits current projected public health importance. Specific important features include recruitment, intent obtaining family groups; breadth depth phenotype information, including detailed...
Alcohol consumption has been linked to over 200 diseases and is responsible for 5% of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, example, ALDH2 ADH1B, are strongly associated with but have limited impact European populations where they found at low frequency. We performed a genome-wide association study (GWAS) self-reported 112 117 individuals UK Biobank (UKB) sample white British individuals. report significant associations 14 loci. These include...
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic indirect effects, but large-scale family datasets have been lacking. We combined data 178,086 siblings 19 cohorts to generate population (between-family) within-sibship (within-family) estimates 25...
There is great interest in widening the use of high-sensitivity cardiac troponins for population cardiovascular disease (CVD) and heart failure screening. However, it not clear whether troponin T (cTnT) I (cTnI) are equivalent measures risk this setting. We aimed to compare contrast (1) association cTnT cTnI with CVD non-CVD outcomes, (2) their determinants a genome-wide study.High-sensitivity were measured serum from 19 501 individuals Generation Scotland Scottish Family Health Study....
Abstract Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has strong heritable basis. We report genome-wide association analysis 34,627 CRC cases 71,379 controls European ancestry that identifies SNPs at 31 new risk loci. also identify eight independent the previously reported loci, further nine loci only identified in Asian populations. use situ promoter capture Hi-C (CHi-C), gene expression, silico annotation methods to likely target genes SNPs. Whilst...
Genome-wide DNA methylation (DNAm) profiling has allowed for the development of molecular predictors a multitude traits and diseases. Such may be more accurate than self-reported phenotypes could have clinical applications. Here, penalized regression models are used to develop DNAm ten modifiable health lifestyle factors in cohort 5087 individuals. Using an independent test comprising 895 individuals, proportion phenotypic variance explained each trait is examined DNAm-based genetic...
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of disease 139 inpatients by measuring 86 accredited diagnostic parameters, such as blood cell counts enzyme activities, well untargeted plasma proteomes at 687 sampling points. report an initial spike a systemic inflammatory response, which gradually alleviated followed protein signature indicative tissue repair,...