Lars G. Fritsche
A5006257131- COVID-19 and healthcare impacts
- Genetic Associations and Epidemiology
- Cancer Immunotherapy and Biomarkers
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Folate and B Vitamins Research
- Nutrition, Genetics, and Disease
- Advanced Causal Inference Techniques
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Radiomics and Machine Learning in Medical Imaging
- Genetic and phenotypic traits in livestock
- Genomics and Rare Diseases
- Gene expression and cancer classification
- Lipid metabolism and disorders
- Molecular Biology Techniques and Applications
University of Michigan
2016-2025
Michigan United
2016-2025
Michigan Medicine
2018-2024
Statistical Research (United States)
2017-2023
U-M Rogel Cancer Center
2023
ORCID
2021
Norwegian University of Science and Technology
2017-2020
St Olav's University Hospital
2019
German Center for Diabetes Research
2018
University of Tübingen
2018
Age-related macular degeneration (AMD) is a multifactorial disease and prevalent cause of visual impairment in developed countries. Risk factors include environmental components genetic determinants. The complement factor H (CFH) has been the first major susceptibility gene for AMD identified within 1q32. Here, we focused on second region interest 10q26 where recent meta-analysis revealed strongest evidence linkage to at genome-wide significance level. Within an interval 22 Mb, have analyzed...
Dysregulation of the alternative pathway (AP) complement cascade has been implicated in pathogenesis age-related macular degeneration (AMD), leading cause blindness elderly. To further test hypothesis that defective control activation underlies AMD, parameters blood plasma were determined together with disease-associated genetic markers AMD patients. Plasma concentrations products C3d, Ba, C3a, C5a, SC5b-9, substrate proteins C3, C4, factor B and regulators H D quantified patients (n = 112)...
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants 11 osteoarthritis phenotypes, 52 of which have not been the disease before. We report thumb spine differences in genetic effects between weight-bearing non-weight-bearing joints. sex-specific early age-at-onset loci. integrate functional genomics data from...
Black patients are overrepresented in the number of COVID-19 infections, hospitalizations, and deaths US. Reasons for this disparity may be due to underlying comorbidities or sociodemographic factors that require further exploration.To systematically determine patient characteristics associated with racial/ethnic disparities outcomes.This retrospective cohort study used comparative groups tested treated at University Michigan from March 10, 2020, April 22, an outcome update through July 28,...
Abstract Background Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10−8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery additional susceptibility may capture unexplained familial risk. Methods We conducted a GWAS in European descent CRC cases and control subjects using discovery–replication design, followed by examination novel findings multiethnic sample (cumulative n = 163 315). In stage (36 948...
Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, few studies thoroughly investigated their best practices global populations across different diseases. We here utilized data from Global Biobank Meta-analysis Initiative (GBMI) to explore methodological considerations and PRS performance 9 biobanks for 14 disease endpoints. Specifically, we constructed PRSs using pruning thresholding (P + T) PRS-continuous shrinkage (CS). For both methods, a European-based...
Biobanks of linked clinical patient histories and biological samples are an efficient strategy to generate large cohorts for modern genetics research. Biobank recruitment varies by factors such as geographic catchment sampling strategy, which affect biobank demographics research utility. Here, we describe the Michigan Genomics Initiative (MGI), a single-health-system currently consisting >91,000 participants recruited primarily during surgical encounters at Medicine. The enrollment results...