Gail Davies
A5019063314- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Cognitive Abilities and Testing
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Bioinformatics and Genomic Networks
- Genomics and Rare Diseases
- Health, Environment, Cognitive Aging
- Nutrition, Genetics, and Disease
- Genomic variations and chromosomal abnormalities
- Genetic Mapping and Diversity in Plants and Animals
- Alcohol Consumption and Health Effects
- Congenital heart defects research
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Liver Disease Diagnosis and Treatment
- Substance Abuse Treatment and Outcomes
- Folate and B Vitamins Research
- Genetic Syndromes and Imprinting
- Bipolar Disorder and Treatment
- Genetic and phenotypic traits in livestock
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
University of Edinburgh
2015-2024
NHS Lothian
2019-2024
Medical University of Graz
2020
University of Liverpool
2017-2018
University of California, San Diego
2018
Indiana University – Purdue University Indianapolis
2018
Muscular Dystrophy UK
2016
University of Groningen
2015-2016
Newcastle University
2016
Azienda Sanitaria di Firenze
2015
Abstract Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which progressively increased in number with increasing sample sizes the respective studies. Here, we conduct genome-wide association study 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification Diseases (ICD, version 9 or 10)-coded MDD....
Alzheimer's disease (AD) is a public health priority for the 21st century. Risk reduction currently revolves around lifestyle changes with much research trying to elucidate biological underpinnings. We show that self-report of parental history dementia case ascertainment in genome-wide association study 314,278 participants from UK Biobank (27,696 maternal cases, 14,338 paternal cases) valid proxy an AD genetic study. After meta-analysing published consortium data (n = 74,046 25,580 cases...
Quantifying the microstructural properties of human brain's connections is necessary for understanding normal ageing and disease. Here we examine brain white matter magnetic resonance imaging (MRI) data in 3,513 generally healthy people aged 44.64-77.12 years from UK Biobank. Using conventional water diffusion measures newer, rarely studied indices neurite orientation dispersion density imaging, document large age associations with microstructure. Mean diffusivity most age-sensitive measure,...
Alcohol consumption has been linked to over 200 diseases and is responsible for 5% of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, example, ALDH2 ADH1B, are strongly associated with but have limited impact European populations where they found at low frequency. We performed a genome-wide association study (GWAS) self-reported 112 117 individuals UK Biobank (UKB) sample white British individuals. report significant associations 14 loci. These include...
People's differences in cognitive functions are partly heritable and associated with important life outcomes. Previous genome-wide association (GWA) studies of have found evidence for polygenic effects yet, to date, there few replicated genetic associations. Here we use data from the UK Biobank sample investigate contributions variation tests three educational attainment. GWA analyses were performed verbal–numerical reasoning (N=36 035), memory (N=112 067), reaction time (N=111 483)...
Causes of the well-documented association between low levels cognitive functioning and many adverse neuropsychiatric outcomes, poorer physical health earlier death remain unknown. We used linkage disequilibrium regression polygenic profile scoring to test for shared genetic aetiology functions disorders health. Using information provided by published genome-wide study consortia, we created scores 24 vascular–metabolic, neuropsychiatric, physiological–anthropometric traits in participants UK...