Shannon L. Risacher
A5018610871- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Bioinformatics and Genomic Networks
- Advanced Neuroimaging Techniques and Applications
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Gene expression and cancer classification
- Neurological Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Folate and B Vitamins Research
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
- Brain Tumor Detection and Classification
- Medical Imaging Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- MRI in cancer diagnosis
- Neural dynamics and brain function
- Machine Learning in Bioinformatics
- Genomics and Rare Diseases
- Traumatic Brain Injury Research
- Retinal Imaging and Analysis
- Computational Drug Discovery Methods
- Traumatic Brain Injury and Neurovascular Disturbances
Indiana University – Purdue University Indianapolis
2016-2025
Indiana University School of Medicine
2016-2025
Alzheimer’s Disease Neuroimaging Initiative
2009-2025
Indiana University
2014-2024
Seoul National University
2024
Indiana University Bloomington
2011-2023
University School
2011-2022
University of Arkansas for Medical Sciences
2020
Rosa (United States)
2020
University of California, Davis
2020
Abstract Introduction Increasing evidence suggests a role for the gut microbiome in central nervous system disorders and specific gut‐brain axis neurodegeneration. Bile acids (BAs), products of cholesterol metabolism clearance, are produced liver further metabolized by bacteria. They have major regulatory signaling functions seem dysregulated Alzheimer's disease (AD). Methods Serum levels 15 primary secondary BAs their conjugated forms were measured 1464 subjects including 370 cognitively...
The Alzheimers Disease Neuroimaging Initiative (ADNI) is a multi-center study assessing neuroimaging in diagnosis and longitudinal monitoring. Amnestic Mild Cognitive Impairment (MCI) often represents prodromal form of dementia, conferring 10-15% annual risk converting to probable AD. We analyzed baseline 1.5T MRI scans 693 participants from the ADNI cohort divided into four groups by one year MCI AD conversion status identify phenotypes associated with potential predictive markers imminent...
The role of the Alzheimer's Disease Neuroimaging Initiative Genetics Core is to facilitate investigation genetic influences on disease onset and trajectory as reflected in structural, functional, molecular imaging changes; fluid biomarkers; cognitive status. Major goals include (1) blood sample processing, genotyping, dissemination, (2) genome‐wide association studies (GWAS) longitudinal phenotypic data, (3) providing a central resource, point contact planning group for genetics within...
Abstract Introduction The Alzheimer's Disease Research Summits of 2012 and 2015 incorporated experts from academia, industry, nonprofit organizations to develop new research directions transform our understanding disease (AD) propel the development critically needed therapies. In response their recommendations, big data at multiple levels are being generated integrated study network failures in disease. We used metabolomics as a global biochemical approach identify peripheral metabolic...
Research increasingly suggests that subjective cognitive decline (SCD) in older adults, the absence of objective dysfunction or depression, may be a harbinger non-normative and eventual progression to dementia. Littl
Abstract Introduction In this multicenter study on subjective cognitive decline (SCD) in community‐based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) non‐AD dementia (2) determinants progression to dementia. Methods Eleven cohorts provided 2978 participants with SCD 1391 controls. We estimated identified risk factors using Cox proportional hazards models. Results SCD, was 17.7 (95% Poisson confidence interval 15.2‐20.3)/1000 person‐years (AD: 11.5...
<h3>Importance</h3> The use of anticholinergic (AC) medication is linked to cognitive impairment and an increased risk dementia. To our knowledge, this the first study investigate association between AC neuroimaging biomarkers brain metabolism atrophy as a proxy for understanding underlying biology clinical effects medications. <h3>Objective</h3> assess cognition, glucose metabolism, in cognitively normal older adults from Alzheimer's Disease Neuroimaging Initiative (ADNI) Indiana Memory...
Bile acids (BAs) are the end products of cholesterol metabolism produced by human and gut microbiome co-metabolism. Recent evidence suggests microbiota influence pathological features Alzheimer's disease (AD) including neuroinflammation amyloid-β deposition.Serum levels 20 primary secondary BA metabolites from AD Neuroimaging Initiative (n = 1562) were measured using targeted metabolomic profiling. We assessed association BAs with "A/T/N" (amyloid, tau, neurodegeneration) biomarkers for AD:...
<h3>Importance</h3> Increasing evidence suggests an important role of liver function in the pathophysiology Alzheimer disease (AD). The is a major metabolic hub; therefore, investigating association with AD, cognition, neuroimaging, and CSF biomarkers would improve understanding dysfunction AD. <h3>Objective</h3> To examine whether markers are associated cognitive "A/T/N" (amyloid, tau, neurodegeneration) for <h3>Design, Setting, Participants</h3> In this cohort study, serum-based were...
Abstract Microglia, the resident immune cells of brain, have important roles in brain health. However, little is known about regulation and consequences microglial activation aging human brain. Here we report that proportion morphologically activated microglia (PAM) postmortem cortical tissue strongly associated with β-amyloid, tau-related neuropathology, rate cognitive decline. Effect sizes for PAM measures are substantial, comparable to APOE ε4, strongest genetic risk factor Alzheimer’s...
CSF levels of Aβ1-42, t-tau, and p-tau181p are potential early diagnostic markers for probable Alzheimer disease (AD). The influence genetic variation on these has been investigated candidate genes but not a genome-wide basis. We report association study (GWAS) biomarkers (Aβ1-42, p-tau181p, p-tau181p/Aβ1-42, t-tau/Aβ1-42).A total 374 non-Hispanic Caucasian participants in the Alzheimer's Disease Neuroimaging Initiative cohort with quality-controlled genotype data were included this...
Abstract Introduction This study assessed apolipoprotein E ( APOE ) ε4 carrier status effects on Alzheimer's disease imaging and cerebrospinal fluid (CSF) biomarkers in cognitively normal older adults with significant memory concerns (SMC). Methods Cognitively normal, SMC, early mild cognitive impairment participants from Disease Neuroimaging Initiative were divided by status. Diagnostic evaluated emphasis SMC. Additional analyses SMC the effect of interaction between [ 18 F]Florbetapir...
Abstract Motivation: Recent advances in high-throughput genotyping and brain imaging techniques enable new approaches to study the influence of genetic variation on structures functions. Traditional association studies typically employ independent pairwise univariate analysis, which treats single nucleotide polymorphisms (SNPs) quantitative traits (QTs) as isolated units ignores important underlying interacting relationships between units. New methods are proposed here overcome this...
Default mode network (DMN) disruption has been reported in Alzheimer's disease (AD), yet the specific pattern of altered connectivity over course prodromal AD remains to be characterized. The aim this study was assess DMN