A5100618912- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Genomics and Rare Diseases
- Multiple Myeloma Research and Treatments
- Genetic Associations and Epidemiology
- Biochemical effects in animals
- RNA regulation and disease
- Genomics and Phylogenetic Studies
- Genomic variations and chromosomal abnormalities
- Neurological Disease Mechanisms and Treatments
- Caveolin-1 and cellular processes
- vaccines and immunoinformatics approaches
- Mycorrhizal Fungi and Plant Interactions
- Alzheimer's disease research and treatments
- RNA and protein synthesis mechanisms
- T-cell and B-cell Immunology
- Viral gastroenteritis research and epidemiology
- Chemokine receptors and signaling
- Chromosomal and Genetic Variations
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Ecology and Conservation Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Genetic and Kidney Cyst Diseases
Dana-Farber Cancer Institute
2024
Broad Institute
2023-2024
Macrogen (South Korea)
2012-2023
Seoul National University
2011-2022
New Generation University College
2022
Hallym University
2021
Seoul National University Bundang Hospital
2020
Green Cross (South Korea)
2019
Korea Research Institute of Bioscience and Biotechnology
2019
National Forensic Institute
2019
Abstract Nuclear compartments are prominent features of 3D chromatin organization, but sequencing depth limitations have impeded investigation at ultra fine-scale. CTCF loops generally studied a finer scale, the impact looping on proximal interactions remains enigmatic. Here, we critically examine nuclear and loop-proximal using combination in situ Hi-C unparalleled depth, algorithm development, biophysical modeling. Producing large map with 33 billion contacts conjunction an for performing...
CSF levels of Aβ1-42, t-tau, and p-tau181p are potential early diagnostic markers for probable Alzheimer disease (AD). The influence genetic variation on these has been investigated candidate genes but not a genome-wide basis. We report association study (GWAS) biomarkers (Aβ1-42, p-tau181p, p-tau181p/Aβ1-42, t-tau/Aβ1-42).A total 374 non-Hispanic Caucasian participants in the Alzheimer's Disease Neuroimaging Initiative cohort with quality-controlled genotype data were included this...
Caveolin-1 (Cav1) is an integral membrane, scaffolding protein found in plasma membrane invaginations (caveolae). Cav1 regulates multiple cancer-associated processes. In breast cancer, a tumor suppressive role for has been suggested; however, frequently overexpressed aggressive cancer subtypes, suggesting oncogenic function advanced-stage disease. To further delineate progression, we evaluated its expression levels among panel of cell lines representing spectrum phenotypes. basal-like (the...
Underrepresentation of non-European (EUR) populations hinders growth global precision medicine. Resources such as imputation reference panels that match the study population are necessary to find low-frequency variants with substantial effects. We created a panel consisting 14,393 whole-genome sequences including more than 11,000 Asian individuals. Genome-wide association studies were conducted using and population-specific genotype array 72,298 subjects for eight phenotypes. This yields...
Aberrant DNA methylation of CpG islands, island shores and first exons is known to play a key role in the altered gene expression patterns all human cancers. To date, systematic study on effect using high resolution data has not been reported. In this study, we conducted an integrated analysis MethylCap-sequencing Affymetrix microarray for 30 breast cancer cell lines representing different tumor phenotypes. As well-developed methods do currently exist, created series four methods. On...
Here, we present the Northeast Asian Reference Database (NARD), including whole-genome sequencing data of 1779 individuals from Korea, Mongolia, Japan, China, and Hong Kong. NARD provides genetic diversity Korean (n = 850) Mongolian 384) ancestries that were not in 1000 Genomes Project Phase 3 (1KGP3). We combined re-phased genotypes 1KGP3 to construct a union set haplotypes. This approach established robust imputation reference panel for Asians, which yields greatest accuracy rare...
Abstract Background Chronic periodontitis is a multifactorial inflammatory disease resulting in patients exhibiting high levels of factors causing systemic bone destruction that may lead to osteoporosis development. The association between and has been documented; however, the findings remain unclear. This study aimed identify using cross-sectional design Korean Genome Epidemiology Study (KoGES) health examinee data. Methods used epidemiological data from KoGES during 2004–2016. Of 125,324...
The centrosomes in dividing cells follow a series of cyclical events duplication and separation, which are tightly linked to the cell cycle. Serine/threonine-protein kinase NEK7 (NEK7) is centrosomal that required for proper spindle formation during mitosis. In this study, we observed centriole was inhibited NEK7-depleted cells. Ectopic expression centrosome-directed led extra centrioles kinase-activity-dependent manner. We also NEK6-expressing cells, suggesting NEK6 might share biological...
Abstract Megabase-scale intervals of active, gene-rich and inactive, gene-poor chromatin are known to segregate, forming the A B compartments. Fine mapping contents these compartments has been hitherto impossible, owing extraordinary sequencing depths required distinguish between long-range contact patterns individual loci, computational complexity associated calculations. Here, we generate largest published in situ Hi-C map date, spanning 33 billion contacts. We also develop a method,...
Here we report the full genome sequence of Klebsiella pneumoniae KCTC 2242,consisting a 5.26-Mb chromosome (57.6% GC%; 5,035 genes [4,923 encoding known proteins, 112 RNA genes]) and 202-kb plasmid (50.2% 229 [229 proteins]).
Abstract Understanding the tumor microenvironment is important to efficiently identify appropriate patients for immunotherapies in a variety of cancers. Here, we presented microenvironmental analysis 2,033 cancer samples across 7 types: colon adenocarcinoma, skin cutaneous melanoma, kidney renal papillary cell carcinoma, sarcoma, pancreatic glioblastoma multiforme, and pheochromocytoma / paraganglioma from The Cancer Genome Atlas cohort. Unsupervised hierarchical clustering based on gene...
This article reports on the full genome sequence of Paenibacillus terrae HPL-003, which is a gram-positive, endospore-forming, xylanase-producing bacterium isolated from soil found in forest residue Gara Mountain. The strain HPL-003 contains 6,083,395 bp with G+C content 46.77 mol%, 2,633 protein-coding genes, and 117 structural RNAs.
ABSTRACT We have identified LB-AUT7 , a gene differentially expressed 6 h after ectomycorrhizal interaction between Laccaria bicolor and Pinus resinosa . LB-Aut7p can functionally complement its Saccharomyces cerevisiae homolog, which is involved in the attachment of autophagosomes to microtubules. Our findings suggest induction an autophagocytosis-like vesicular transport process during interaction.
This study aimed to evaluate the concordance of oncogenic driver mutations between tumor tissues and circulating DNA (ctDNA) in patients with lung cancer. In addition, this attempted reveal clinical utility ctDNA cancer treatment.Recurrent or metastatic non-small cell (NSCLC) were prospectively enrolled study. Tumor tissue serial blood samples obtained from newly diagnosed (Cohort A) treated targeted therapy B) gene panel sequencing was conducted identify mutational profiles.At time...
DegP is a highly conserved protease that performs regulated proteolysis to selectively remove misfolded proteins in the periplasm of Escherichia coli Binding known be main mechanism activation, but it unknown whether any native can alter activity. Here, we show small periplasmic protein, YjfN, which upregulated by Cpx envelope stress response, functions as "suicide activator" for and promotes efficient degradation proteins. YjfN readily binds degraded DegP, hydrophobic C-terminal residue...
This paper proposes a real-time image selection algorithm for fingerprint recognition system, which uses the embedded camera of mobile device. In general, auto-focusing algorithms system use gradient measures to estimate high-frequency components an image. device, images are greatly affected by environmental light sources. Therefore, obtained might not qualify even when is focused. Consequently, should be investigated whether it usable or not. Variance-modified-Laplacian Gaussian (VMLOG) and...
Abstract Background Low-pass sequencing (LPS) has been extensively investigated for applicability to various genetic studies due its advantages over genotype array data including cost-effectiveness. Predicting the risk of complex diseases such as Parkinson’s disease (PD) using polygenic score (PRS) based on variations shown decent prediction accuracy. Although ultra-LPS be effective in PRS calculation, favored majority analysis, especially PD. Results Using eight high-coverage WGS, we...