A5029628786- Global Cancer Incidence and Screening
- Genetic Associations and Epidemiology
- Viral-associated cancers and disorders
- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Cancer survivorship and care
- Cancer-related gene regulation
- Lymphoma Diagnosis and Treatment
- Genital Health and Disease
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- BRCA gene mutations in cancer
- HIV/AIDS Research and Interventions
- Chronic Disease Management Strategies
- Polyomavirus and related diseases
- HIV/AIDS drug development and treatment
- Epigenetics and DNA Methylation
University of the Witwatersrand
2017-2025
Martin Luther University Halle-Wittenberg
2025
National Health Laboratory Service
2014-2025
Air Force Medical University
2025
Xijing Hospital
2025
National Cancer Registry
2020-2024
Institute for Molecular Science
2023
Africa Health Research Institute
2019-2022
University of KwaZulu-Natal
2021
Stellenbosch University
2020
Abstract Background Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates prostate cancer in men African descent, much what is known about genetics comes from populations European descent. To understand how genetic predictions perform different we evaluated test characteristics PRS three previous using data UK Biobank a novel dataset 1298 cases 1333 controls...
Abstract Although prostate cancer is the leading cause of mortality for African men, vast majority known disease associations have been detected in European study cohorts. Furthermore, most genome-wide association studies used genotyping arrays that are hindered by SNP ascertainment bias. To overcome these disparities genomic medicine, Men Descent and Carcinoma Prostate (MADCaP) Network has developed a array optimized populations. The MADCaP Array contains more than 1.5 million markers an...
South Africa (SA) has experienced a rapid transition in the Human Development Index (HDI) over past decade, which had an effect on incidence and mortality rates of colorectal cancer (CRC). This study aims to provide CRC trends by population group sex SA from 2002 2014.Incidence data were extracted African National Cancer Registry obtained Statistics (STATS SA), for period 2014. Age-standardised (ASIR) age-standardised (ASMR) calculated using STATS mid-year as denominator Segi world standard...
Abstract Background Cervical cancer remains a leading cause of death, particularly in developing countries. WHO screening guidelines recommend human papilloma virus (HPV) detection as means to identify women at risk cervical cancer. While HPV testing identifies those risk, it does not specifically distinguish individuals with neoplasia. We investigated whether quantitative molecular test that measures methylated DNA markers could high-risk lesions the cervix accuracy. Results Marker...
Long-term storage of whole blood can affect the integrity DNA if it is not done under optimal conditions. The aim this study was to determine whether long-term (2-19 years) samples at -30°C had a negative effect on quality or quantity genomic that could be recovered extraction. Genomic isolated from 2758 collected in 4 mL EDTA vacutainers 1997 2012. extracted using Qiagen® FlexiGene® kit. average duration 12 years. and were assessed spectrophotometry (NanoDrop™), fluorometric assay for...
In some countries of sub-Saharan Africa, the prevalence HIV exceeds 20%; in South 20.4% people are living with HIV. We examined impact infection on overall survival (OS) women nonmetastatic breast cancer (BC) enrolled African Breast Cancer and Outcomes (SABCHO) study. recruited newly diagnosed BC at six public hospitals from 1 July 2015 to 30 June 2019. Among stages I-III BC, we compared those without sociodemographic, clinical, treatment factors. analyzed OS using multivariable Cox...
Background. Monitoring quality indicators to improve breast cancer care is well established in high-income countries. This the first evaluation of diagnostic and surgical for initial benchmarking South Africa (SA). Objective. To measure adherence rates among women with SA. Methods. Ten were evaluated 3 545 patients across four SA units using a shared electronic patient record system. Data differences between determined. The effect HIV status on was assessed by multivariate Poisson regression...
Abstract Sepsis is a leading cause of death, with the liver being particularly vulnerable to sepsis-related injuries. This damage significantly contributes disease progression, underscoring need for new treatments. Brown adipose tissue (BAT) secretes various cytokines, including neuregulin 4 (Nrg4), which plays protective role in hepatic glucose and lipid metabolism. Ferroptosis, key type cell death sepsis-induced injury, has recently gained attention. study aimed investigate how...
Androgenetic alopecia is a highly heritable trait. However, much of our understanding about the genetics male pattern baldness comes from individuals European descent. Here, we examined dataset comprising 2,136 men Ghana, Nigeria, Senegal, and South Africa that were genotyped using MADCaP Array. We first tested how genetic predictions generalize Europe to found polygenic scores GWAS yielded AUC statistics ranged 0.513 0.546, indicating generalized poorly African populations. Subsequently,...
Abstract Genome-wide association studies (GWAS) have characterized the contribution of common variants to breast cancer (BC) risk in populations European ancestry, however GWAS not been reported resident African populations. This included 2485 BC cases and 1101 population matched controls. Two loci were identified, located between UNC13C RAB27A on chromosome 15 (rs7181788, p = 1.01 × 10 −08 ) USP22 17 (rs899342, 4.62 ). Several genome-wide significant signals also detected hormone receptor...
Abstract Introduction: Breast cancer genome-wide association studies (GWAS) have identified over 200 susceptibility loci, many replicated in diverse populations. However, cross-ancestry evaluation of breast genetic architecture remains limited. We examined using GWAS summary results from European (EUR; cases (ca) = 188,474, controls (co) 96,201), East Asian (EAS; ca 20,393, co 86,329), African American (AA; 9,235, 10,184), and US Hispanic/Latina Latin (H/L; 2,396, =7,468) studies. Methods:...
Abstract The breast cancer (BC)-related mortality is higher and the immunity altered in women living with HIV (WLWH) compared to HIV-negative women. Therefore, tumor samples of 296 black BC patients from South Africa Namibia known age, status, stage, hormone receptor HER2 status overall survival (OS) are analyzed for components microenvironment (TME). WLWH ( n = 117), either suppressed viral activity (HR 1.25) or immune suppression 2.04), have a shorter OS. associated increased numbers CD8 +...
11158 Background: Sub-Saharan Africa (SSA) has very low breast cancer (BC) survival. South Africa, unlike most SSA countries, is an upper middle-income country where patients are less burdened with diagnostic and treatment costs. We aimed to provide five-year overall survival (OS) estimates determinants among African women BC diagnosed treated within the public health system. Methods: The Breast Cancer HIV Outcomes prospective cohort study enrolled adult recently invasive from four academic...
The South African HIV Cancer Match (SAM) Study is a national cohort of people living with (PLWH). It was created using probabilistic record linkages routine laboratory records PLWH retrieved by National Health Laboratory Services (NHLS) and cancer data from the Registry. SAM aims to assess spectrum risk in context evolving epidemic. Study's overarching goal inform prevention control programmes era antiretroviral treatment Africa.
Cancer of the prostate (CaP) is leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion these with CaP are diagnosed at late (usually incurable) stages, yet little known about etiology SSA.
PURPOSE The quality of breast cancer care in sub-Saharan Africa contributes to the region’s dismal mortality. ASCO has issued measures focusing on delivery adjuvant chemotherapy, radiotherapy, and endocrine therapy. We applied these five South African public hospitals analyzed factors associated with concordance. MATERIALS AND METHODS Among 1,736 women who were enrolled Breast Cancer HIV Outcomes study over 24 months, we evaluated using ASCO’s three measures. also chemotherapy receipt 957 an...
Lung cancer is the highest incident globally and associated with significant morbidity mortality particularly if identified at a late stage. Poor patient outcomes in low- middle-income countries (LMIC's) might reflect contextual health system constraints multiple levels, that act as barriers to prevention, disease recognition, diagnosis, treatment. screening, even for high-risk patients, not available public sector South Africa (SA), where current HIV tuberculosis (TB) epidemics often take...
Abstract South Africa's HIV epidemic has evolved over time in terms of numbers people living with HIV, access to antiretroviral treatment (ART) and age. These changes have profoundly influenced local cancer patterns. The Johannesburg Cancer Study has, a period 22 years (1995‐2016), recruited 20 000 incident black patients who consented provide answers questionnaire blood samples (serum, DNA). This presented unique opportunity examine the evolving association Africa. We used logistic...
Abstract Background Breast cancer survival in South Africa is low, but when diagnosed with breast cancer, many women also have other chronic conditions. We investigated the impact of multimorbidity (≥ 2 conditions) on overall among Africa. Methods Between 1 July 2015 and 31 December 2019, we enrolled newly at six public hospitals participating African Cancer HIV Outcomes (SABCHO) Study. examined seven conditions (obesity, hypertension, diabetes, HIV, cerebrovascular diseases (CVD),...