A5063231601- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Ferroptosis and cancer prognosis
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Lymphoma Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Circular RNAs in diseases
- Acute Myeloid Leukemia Research
- Cancer Cells and Metastasis
- Viral-associated cancers and disorders
- Advanced Breast Cancer Therapies
- Esophageal Cancer Research and Treatment
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Peripheral Artery Disease Management
- HER2/EGFR in Cancer Research
Martin Luther University Halle-Wittenberg
2018-2025
St. Vincenz-Krankenhaus Limburg
2016-2025
University Hospital in Halle
2018-2024
Universität Hamburg
2022-2024
University Medical Center Hamburg-Eppendorf
2022-2024
Luther University
2023
University of Hildesheim
2022
Air Liquide (Germany)
2021
Universitätsklinikum Erlangen
2021
Friedrich-Alexander-Universität Erlangen-Nürnberg
2004-2021
Phosphatidylinositide-3-kinase (PI3K) regulates proliferation and apoptosis; somatic PIK3CA-mutations may activate these processes. Aim of this study was to determine the prevalence in a cohort early stage breast cancer patients association course disease.From an unselected 1270 (PiA, Prognostic Assessment routine application, NCT01592825) 1123 tumours were tested for three PIK3CA hotspot-mutations H1047R, E545K, E542K by qPCR. Primary objectives their tumour characteristics. Secondary...
Inter-patient variability and the similarity of healthy leukemic stem cells (LSCs) have impeded characterization LSCs in acute myeloid leukemia (AML) their differentiation landscape. Here, we introduce CloneTracer, a novel method that adds clonal resolution to single-cell RNA-seq datasets. Applied samples from 19 AML patients, CloneTracer revealed routes differentiation. Although residual preleukemic dominated dormant cell compartment, active resembled counterpart retained erythroid...
Coronary artery calcification (CAC) is a noninvasive marker of plaque load that predicts myocardial infarcts in the general population. Herein, we investigated whether CAC stroke events addition to established risk factors are part Framingham score.A total 4180 subjects from population-based Heinz Nixdorf Recall study (45-75 years age; 47.1% men) without previous stroke, coronary heart disease, or infarction were evaluated for over 94.9 ± 19.4 months. Cox proportional hazards regressions...
<h3>Importance</h3> In metastatic esophagogastric adenocarcinoma (EGA), the addition of programmed cell death 1 (PD-1) inhibitors to chemotherapy has improved outcomes in selected patient populations. <h3>Objective</h3> To investigate efficacy trastuzumab and PD-1 with cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) or FOLFOX first-line treatment advanced<i>ERBB2</i>-positive EGA. <h3>Design, Setting, Participants</h3> This phase 2 multicenter, outpatient, randomized clinical trial...
Abstract Aim Coronary artery calcification (CAC), as a sign of atherosclerosis, can be detected and progression quantified using computed tomography (CT). We develop tool for predicting CAC progression. Methods results In 3481 participants (45–74 years, 53.1% women) percentiles at baseline (CACb) after five years (CAC5y) were evaluated, demonstrating along gender-specific percentiles, which showed exponentially shaped age-dependence. Using quantile regression on the log-scale (log(CACb+1))...
AimsEpicardial adipose tissue (EAT) is increased in subjects with atrial fibrillation (AF). Likewise, EAT associated left (LA) size, as itself a strong predictor of AF. We aimed to determine the association and LA size computed tomography (CT)-derived measures prevalent incident AF investigated whether both independently predict
To compare the predictive value of coronary artery calcification (CAC), carotid intima-media thickness (CIMT) and ankle-brachial index (ABI) in a primary prevention cohort depending on risk factor profile to determine which three markers improves cardiovascular (CV) discrimination best group.We quantified CAC, CIMT, ABI 3108 subjects (mean age 59.2 ± 7.7, 47.1% male) without prevalent CV diseases from population-based Heinz Nixdorf Recall study. Associations with incident major events...
Background In patients with microsatellite stable (MSS) metastatic colorectal cancer (mCRC), immune checkpoint blockade is ineffective, and combinatorial approaches enhancing immunogenicity need exploration. Methods We treated 43 predominantly RAS/BRAF wild-type mCRC on a phase II trial combining chemotherapy the epidermal growth factor receptor antibody cetuximab programmed cell death ligand 1 (PD-L1) avelumab. performed next-generation gene panel sequencing for mutational typing of tumors...
Prehypertension is a frequent condition and has been demonstrated to increase cardiovascular risk. However, the association with coronary atherosclerosis as part of target organ damage not well understood. We investigated cross-sectional relationship longitudinal outcome between blood pressure categories artery calcification (CAC), quantified by electron beam computed tomography, in 4181 participants from population-based Heinz Nixdorf Recall Study cohort. At baseline, we observed continuous...
<h3>Background</h3> Aortic valve calcification (AVC) is considered a manifestation of atherosclerosis. In this study, we investigated whether AVC adds to cardiovascular risk prediction beyond Framingham factors and coronary artery (CAC). <h3>Methods</h3> A total 3944 subjects from the population based Heinz Nixdorf Recall Study (59.3±7.7 years; 53% females) were evaluated for events, stroke, disease (CVD) events (including all plus CV death) over 9.1±1.9 years. CT scans performed quantify...
The aorta is a major source of cerebral thromboembolism, but its role in stroke pathogenesis not well understood due to poor accessibility for non-invasive imaging. We examined whether thoracic aortic calcification (TAC), marker plaque load, associated with addition established risk factors.A total 3930 subjects from the population-based Heinz Nixdorf Recall study (45-75 years; 47.1% men) without previous stroke, coronary heart disease, or myocardial infarction were evaluated incident events...
Anaplastic thyroid carcinomas (ATC) are rare, but represent the most lethal malignancy of thyroid. Selective molecular markers and drivers distinguishing ATC from other follicular origin remain largely unknown, limiting advances in diagnosis treatment. In a retrospective study, we analyzed gene expression 36 ATC, 18 poorly differentiated, 132 papillary, 55 carcinoma, as well 124 paired unpaired normal tissues three independent cohorts by RNA-sequencing immunohistochemistry. data test cohort...
Abstract Background Pathologists face major challenges in breast cancer diagnostics sub-Saharan Africa (SSA). The problems identified as impairing the quality of pathology reports are shortcomings equipment, organization and insufficiently qualified personnel. In addition, context cancer, immunohistochemistry (IHC) needs to be available for evaluation biomarkers. study presented, we aim describe current state order highlight unmet needs. Methods We obtained information on services within...
p16 (CDKN2A) is a member of the INK4 class cell cycle inhibitors, which often dysregulated in cancer. However, prevalence expression different cancer types controversial. 15,783 samples from 124 tumor and 76 normal tissue were analyzed by immunohistochemistry microarray format. was detectable 5,292 (45.0%) 11,759 interpretable tumors. Except adenohypophysis islets Langerhans, staining largely absent tissues. In cancer, highest positivity rates observed uterine cervix squamous carcinomas...
The management of patients with an anticipated difficult airway remains challenging. We evaluated laryngeal visualization the recently introduced Vie Scope® as a straight blade laryngoscope consisting illuminated tube necessitating bougie-facilitated intubation vs Macintosh videolaryngoscopy. conducted prospective randomized controlled noninferiority trial. Patients undergoing elective ear, nose, and throat or oral maxillofacial surgery were 1:1 to receive tracheal Scope videolaryngoscope...