A5077205301- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
- Multiple Myeloma Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Colorectal Cancer Treatments and Studies
- Immune cells in cancer
- Mesenchymal stem cell research
- CNS Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- COVID-19 and Mental Health
- Glioma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- Long-Term Effects of COVID-19
- Cancer Genomics and Diagnostics
- Phagocytosis and Immune Regulation
- Glycosylation and Glycoproteins Research
University Hospital of Basel
2023-2025
Martin Luther University Halle-Wittenberg
2019-2025
Hospital Base
2025
University of Basel
2023-2025
Biologie Labor
2024
University Hospital in Halle
2019-2023
University Medical Center Hamburg-Eppendorf
2013-2022
Luther University
2022
Universität Hamburg
2012-2021
University Cancer Center Hamburg
2011-2020
Significance A hyperinflammatory syndrome reminiscent of toxic shock (TSS) is observed in severe COVID-19 patients, including children with Multisystem Inflammatory Syndrome Children (MIS-C). TSS typically caused by pathogenic superantigens stimulating excessive activation the adaptive immune system. We show that SARS-CoV-2 spike contains sequence and structure motifs highly similar to those a bacterial superantigen may directly bind T cell receptors. further report skewed receptor...
Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory associated with SARS-CoV-2 infection, shares clinical features toxic shock syndrome, which is triggered by bacterial superantigens. Superantigen specificity for different Vβ chains results skewing, whereby T cells specific and diverse antigen are overrepresented the cell receptor (TCR) repertoire. Here, we characterized TCR repertoire of MIS-C patients found profound expansion TCRβ variable gene 11-2 (TRBV11-2), up to...
Tissue-resident memory-like T H 17 cells are clonally expanded in bronchoalveolar lavage fluid of patients with severe COVID-19.
Multisystem inflammatory syndrome in children (MIS-C) manifests as a severe and uncontrolled response with multiorgan involvement, occurring weeks after SARS-CoV-2 infection. Here, we utilized proteomics, RNA sequencing, autoantibody arrays, B cell receptor (BCR) repertoire analysis to characterize MIS-C immunopathogenesis identify factors contributing manifestations intensive care unit admission. Inflammation markers, humoral immune responses, neutrophil activation, complement coagulation...
To investigate immuno-chemotherapy for elderly immuno-competent patients (⩾65 years) with newly diagnosed primary central nervous system lymphoma, we conducted a multicentre single-arm trial. One cycle consisted of rituximab (375 mg/m2, days 1, 15, 29), high-dose methotrexate (3 g/m2 2, 16, 30), procarbazine (60 mg/m2 2–11) and lomustine (110 day 2)—R-MPL protocol. Owing to infectious complications, omitted during the study consecutive were treated R-MP Three cycles scheduled repeated on 43....
Purpose: Immunotherapeutic treatment strategies for glioblastoma (GBM) are under investigation in clinical trials. However, our understanding of the immune phenotype GBM-infiltrating T cells (tumor-infiltrating lymphocytes; TILs) and changes during disease progression is limited. Deeper insight urgently needed to therapeutically overcome tumor-induced exhaustion.Experimental Design: We used flow cytometry cytokine assays profile TILs peripheral blood lymphocytes (PBLs) from patients with...
Recent studies suggest that circulating tumor cells and cell-free DNA may represent powerful non-invasive tools for monitoring disease in patients with solid hematologic malignancies. Here, we conducted a pilot study 27 myeloma to explore the clonotypic V(D)J rearrangement DNA. Next-generation sequencing was used define subsequent peripheral blood tracking after treatment initiation. Positivity cells/cell-free associated conventional remission status (P
Post-acute sequelae of COVID-19 (PASC) are long-term consequences SARS-CoV-2 infection that can substantially impair the quality life. Underlying mechanisms ranging from persistent viruses to innate and adaptive immune dysregulation have been discussed. Here, we profiled plasma 181 individuals cohort study for digital health research in Germany (DigiHero), including after mild moderate with or without PASC uninfected controls. We focused on soluble factors related monocyte/macrophage biology...
<h3>Importance</h3> In metastatic esophagogastric adenocarcinoma (EGA), the addition of programmed cell death 1 (PD-1) inhibitors to chemotherapy has improved outcomes in selected patient populations. <h3>Objective</h3> To investigate efficacy trastuzumab and PD-1 with cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) or FOLFOX first-line treatment advanced<i>ERBB2</i>-positive EGA. <h3>Design, Setting, Participants</h3> This phase 2 multicenter, outpatient, randomized clinical trial...
Cetuximab and panitumumab, two antibodies targeting the extracellular domain of epidermal growth factor receptor (EGFR), are major clinical importance particularly in treatment metastatic colorectal cancer. As patients may acquire resistance-mediating mutations within EGFR domain, functional dissection exact binding sites help predict responses. We therefore assessed epitope recognition panitumumab by screening phage-displayed random cyclic 7mer linear 12mer peptide libraries on this...