A5078197206- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Renal Diseases and Glomerulopathies
- Gastrointestinal disorders and treatments
- Endometriosis Research and Treatment
- HIV Research and Treatment
- CRISPR and Genetic Engineering
- Bioactive Compounds and Antitumor Agents
- Cytokine Signaling Pathways and Interactions
- Immune responses and vaccinations
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Dermatology and Skin Diseases
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- RNA Interference and Gene Delivery
- FOXO transcription factor regulation
- Reproductive System and Pregnancy
- Psoriasis: Treatment and Pathogenesis
University Medical Center Hamburg-Eppendorf
2019-2023
Universität Hamburg
2019-2023
Karolinska Institutet
2016
Heidelberg University
2015
University Hospital Heidelberg
2015
Tissue-resident memory-like T H 17 cells are clonally expanded in bronchoalveolar lavage fluid of patients with severe COVID-19.
Innate lymphoid cells (ILCs) have an important role in the immune system's response to different forms of infectious and noninfectious pathologies. In particular, IL-5– IL-13–producing type 2 ILCs (ILC2s) been implicated repair mechanisms that restore tissue integrity after injury. However, presence renal humans has not reported. this study, we show ILC populations are present healthy human kidney. A detailed characterization kidney-residing revealed IL-33 receptor–positive ILC2s a major...
Background & AimsUnregulated activity of interleukin (IL) 22 promotes intestinal tumorigenesis in mice. IL22 binds the antagonist subunit alpha 2 (IL22RA2, also called IL22BP). We studied whether alterations IL22BP contribute to colorectal carcinogenesis humans and mice.MethodsWe obtained tumor nontumor tissues from patients with cancer (CRC) measured levels cytokines by quantitative polymerase chain reaction, flow cytometry, immunohistochemistry. Il22bp messenger RNA colon wild-type,...
Abstract Mucosal-associated invariant T (MAIT) cells have been implicated in various inflammatory diseases of barrier organs, but so far, their role kidney disease is unclear. Here we report that MAIT recognize prototypical ligand, the vitamin B2 intermediate 5-OP-RU presented by MR1, reside human and mouse kidneys. Single cell RNAseq analysis reveals several intrarenal subsets, one, carrying genetic fingerprint tissue-resident MAIT17 cells, activated expanded a murine model crescentic...
The insulin-like growth factor-1 receptor (IGF-1R) is a tyrosine kinase that has crucial roles in cell proliferation and protection from apoptosis. It therefore not surprising IGF-1R often found overexpressed many types of tumors. This made prominent target molecule for pharmacological companies to develop new anti-cancer agents. However, several clinical trials during the last 5 years using specific antibodies have shown disappointing results. We previously upon IGF-1 stimulation, becomes...
In recent years, the cytokine interleukin (IL)-22 attracted considerable attention due to its important immunoregulatory function in barrier tissues, such as gut, lung, and skin. Although a regenerative role of IL-22 renal tubular damage has been demonstrated, immunopathogenesis glomerular injury is still unknown. Here, we demonstrate that receptor expressed compartment kidney expression increases cortex after induction mouse model for crescentic glomerulonephritis (cGN, nephrotoxic...
Innate lymphoid cells (ILCs) that express NK cell receptors (NCRs) and the transcription factor T-bet populate nonlymphoid tissues are crucial in immune responses against viral infections malignancies. Recent studies highlighted heterogeneity of this ILC population extended their functional spectrum to include important roles tissue homeostasis autoimmunity. In article, we provide detailed profiling NCR+T-bet+ populations murine kidney, identifying conventional (cNK) type 1 ILCs (ILC1s) as...
HIV, the human immunodeficiency virus, is highly successful as a viral pathogen due to its ability persist in infected host an integrated proviral DNA within cellular reservoirs, particularly resting CD4+ T cells and macrophages. Current antiretroviral combination therapy can control spread viremia but cannot eradicate latent HIV genomes, raising urgent need for alternative strategies long-term remission or cure. We combined two powerful technologies, synthetic AAV vectors CRISPR-mediated...