A5003555223- Immune Response and Inflammation
- Antimicrobial Resistance in Staphylococcus
- Antimicrobial Peptides and Activities
- T-cell and B-cell Immunology
- Immune responses and vaccinations
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diabetes and associated disorders
- Psoriasis: Treatment and Pathogenesis
- Single-cell and spatial transcriptomics
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
University Medical Center Hamburg-Eppendorf
2020-2024
Universität Hamburg
2020-2024
Tissue-resident memory-like T H 17 cells are clonally expanded in bronchoalveolar lavage fluid of patients with severe COVID-19.
Although it is well established that microbial infections predispose to autoimmune diseases, the underlying mechanisms remain poorly understood. After infection, tissue-resident memory T (TRM) cells persist in peripheral organs and provide immune protection against reinfection. However, whether TRM participate responses unrelated primary such as inflammation, unknown. By using high-dimensional single-cell analysis, we identified CD4+ with a TH17 signature (termed TRM17 cells) kidneys of...
Staphylococcus aureus is frequently detected in patients with sepsis and thus represents a major health burden worldwide. CD4+ T helper cells are involved the immune response to S. by supporting antibody production phagocytosis. In particular, Th1 Th17 secreting IFN-γ IL-17A, control of systemic infections humans mice. To investigate role severe infections, we established mouse model which kidney was identified be organ highest bacterial load abundance cells. this model, IL-17A but not...
Pro-inflammatory CD4 + T cells are major drivers of autoimmune diseases, yet therapies modulating cell phenotypes to promote an anti-inflammatory state lacking. Here, we identify helper 17 (T H 17) plasticity in the kidneys patients with antineutrophil cytoplasmic antibody–associated glomerulonephritis on basis single-cell (sc) receptor analysis and scRNA velocity. To uncover molecules driving polarization plasticity, established vivo pooled scCRISPR droplet sequencing (iCROP-seq) screen...