Laurent Alric
A5061653039- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- Systemic Lupus Erythematosus Research
- Liver Diseases and Immunity
- HIV/AIDS drug development and treatment
- Chronic Lymphocytic Leukemia Research
- Viral gastroenteritis research and epidemiology
- Vasculitis and related conditions
- Drug-Induced Hepatotoxicity and Protection
- Platelet Disorders and Treatments
- Inflammatory Bowel Disease
- Viral-associated cancers and disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Microscopic Colitis
- Pancreatitis Pathology and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Clostridium difficile and Clostridium perfringens research
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal motility and disorders
- Lymphoma Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Université Toulouse III - Paul Sabatier
2016-2025
Hôpital Rangueil
2009-2025
Hôpital Pellegrin
2025
Médecins du Monde
2025
Hôpital Paul-Brousse
2025
Laboratoire d'Étude des Microstructures et de Mécanique des Matériaux
2025
Université de Lorraine
2022-2025
Groupe Français de Transplantation Fécale
2024-2025
Université de Toulouse
2014-2024
Centre Hospitalier Universitaire de Toulouse
2015-2024
Summary Background Hepatic venous pressure gradient (HVPG) is a prognostic marker in patients with cirrhosis. Transient elastography measures liver stiffness (LS). Aim To assess the correlation between LS and HVPG to investigate performance of transient for diagnosis significant portal hypertension (PHT). Methods Liver was measured by Fibroscan 150 consecutive who underwent biopsy haemodynamic measurements. Usual clinical biological data were collected. Significant PHT defined as ≥10 mmHg....
Lactic acid–producing bacteria engineered to produce the antiprotease Elafin restore colon homeostasis in mice with colitis and protect human tissue from inflammation.
Chinese translation Background: Hepatitis C virus (HCV) infections occur worldwide and either spontaneously resolve or persist markedly increase the person's lifetime risk for cirrhosis hepatocellular carcinoma. Although HCV persistence occurs more often in persons of African ancestry with genetic variants near interleukin-28B (IL-28B), basis is not well-understood. Objective: To evaluate host spontaneous resolution infection. Design: 2-stage, genome-wide association study. Setting: 13...
There is no approved therapy for hepatitis C virus (HCV) infection after kidney transplantation, and data regarding the use of new-generation direct antiviral agents (DAAs) have been published so far. The aims this pilot study were to assess efficacy safety an interferon-free sofosbuvir-based regimen treat chronic HCV in transplant recipients. Twenty-five recipients with given, 12 (n = 19) or 24 weeks 6), sofosbuvir plus ribavirin 3); daclatasvir 4); simeprevir, 1) without 6); ledipasvir,...
Abstract A total of 431 consecutive patients from the Midi Pyrenees area with acute hepatitis unknown etiology in 2001–2002 were tested for presence immunoglobulin G‐class (IgG) anti‐hepatitis E virus (HEV) antibodies. Forty‐six (10.7%) had anti‐HEV IgG, and results questionable a further 17 (3.9%). Real time PCR based on TaqMan detection was used to identify HEV genome fragments serum positive or serology. RNA found 25.4% cases. All amplification products sequenced analyzed. Phylogenetic...
We report the results of adapting medical therapy to monitoring hemodynamic response in prevention a first variceal bleeding or rebleeding patients with cirrhosis. Hepatic venous pressure gradient (HVPG) was measured before and after propranolol initiated. The were considered responders if HVPG decreased below 12 mm Hg at least 20% as compared baseline value. If not responders, isosorbide-5 mononitrate (I-5MN) added, third study performed. Thereafter, followed for mean 28 months. Thirty-four...
Abstract Cases of autochthonous acute hepatitis E occur in most industrialized countries and are frequent the South West France. The prevalence anti‐hepatitis virus (HEV) IgG antibodies blood donors this area was determined. A total 529 samples from rural urban were tested. overall 16.6%, 19.1% 14.2% had anti‐HEV ( P = 0.13). widely distributed among all age groups sex ratio positive 1.12 0.57). Hunting only pastime or profession associated with a high 0.038). frequency could reflect active...
<h3>Background</h3> Hepatitis C virus (HCV) is the aetiological agent for most cases of cryoglobulinaemia vasculitis. Interferon-containing regimens are associated with important side effects and may exacerbate <h3>Objective</h3> To evaluate safety efficacy an oral interferon-free regimen, sofosbuvir plus ribavirin, in HCV-cryoglobulinaemia <h3>Patients methods</h3> We enrolled 24 consecutive patients (median age 56.5 years 46% women) Sofosbuvir (400 mg/day) was ribavirin (200–1400 mg/day),...
In most patients with nonsevere systemic necrotizing vasculitides (SNVs), remission is achieved glucocorticoids alone, but one-third experience a relapse within 2 years. This study was undertaken to determine whether the addition of azathioprine (AZA) could achieve higher sustained rate newly diagnosed eosinophilic granulomatosis polyangiitis (Churg-Strauss) (EGPA), microscopic (MPA), or polyarteritis nodosa (PAN).All included in this double-blind trial received glucocorticoids, gradually...
This study assessed the efficacy and safety of ribavirin‐free coformulated glecaprevir/pibrentasvir (G/P) in patients with hepatitis C virus genotype 3 infection prior treatment experience and/or compensated cirrhosis, a patient population limited options. SURVEYOR‐II, Part was partially randomized, open‐label, multicenter, phase study. Treatment‐experienced (prior interferon or pegylated ± ribavirin sofosbuvir plus therapy) without cirrhosis were randomized 1:1 to receive 12 16 weeks G/P...