Élisabeth Diot
A5003360902- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Dermatologic Treatments and Research
- Renal Diseases and Glomerulopathies
- Salivary Gland Disorders and Functions
- Mast cells and histamine
- Skin Diseases and Diabetes
- Sarcoidosis and Beryllium Toxicity Research
- Pulmonary Hypertension Research and Treatments
- Autoimmune Bullous Skin Diseases
- Otitis Media and Relapsing Polychondritis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatological and Skeletal Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Occupational and environmental lung diseases
- Pregnancy and Medication Impact
- Urticaria and Related Conditions
- Vascular Anomalies and Treatments
- Connective Tissue Growth Factor Research
- Medical Imaging and Pathology Studies
Centre Hospitalier Universitaire de Tours
2016-2025
Université de Tours
2012-2025
Centre Val de Loire
2024
Hôpital Bretonneau
2015-2024
Centre Hospitalier René-Dubos
2021
Thion Medical (France)
2019
DuPont (France)
2019
Hôpital Avicenne
2014-2018
Hôpital Saint-Jacques
2018
Groupe d'Oncologie Radiothérapie Tête et Cou
2017
Abstract Objective Screening allows for early management of pulmonary arterial hypertension (PAH), a severe complication systemic sclerosis (SSc). Since no consensus has been reached on the method and criteria optimal screening, we sought to develop an algorithm based symptoms, Doppler echocardiography, right heart catheterization (RHC) application nationwide multicenter SSc population in France. Methods This prospective study was conducted from September 2002 July 2003 by experts at 21...
Necrotizing autoimmune myopathy (NAM) is a group of acquired myopathies characterized by prominent myofiber necrosis with little or no muscle inflammation. Recently, researchers identified autoantibodies (aAb) against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in patients NAM, especially statin-exposed patients. Here we report what to our knowledge the first European cohort NAM.The serum 206 suspicion NAM was tested for detection anti-HMGCR aAb using an addressable laser bead...
Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune system and connective tissue. SSc stands out as a severely incapacitating life-threatening rheumatic disease, with largely unknown pathogenesis. We have designed two-stage genome-wide association study of using case-control samples from France, Italy, Germany, Northern Europe. The initial scan was conducted in French post quality-control sample 564 cases 1,776 controls, almost 500 K SNPs. Two SNPs MHC...
An algorithm for the detection of pulmonary arterial hypertension (PAH), based on presence dyspnea and findings Doppler echocardiographic evaluation velocity tricuspid regurgitation (VTR) right-sided heart catheterization (RHC), which was applied in a large multicenter systemic sclerosis (SSc) population, estimated prevalence PAH to be 7.85%. The aim this observational study investigate incidence (PH) during 3-year followup patients from same cohort (the ItinérAIR-Sclérodermie...
Type I cryoglobulinemia vasculitis (CryoVas) is considered a life-threatening condition; however, data on the characteristics and outcome are scarce. To analyze presentation, prognosis, efficacy safety of treatments type CryoVas, we conducted French nationwide survey that included 64 patients with CryoVas between January 1995 July 2010: 28 monoclonal gammopathy unknown significance (MGUS) 36 hematologic malignancy.Type was characterized by severe cutaneous involvement (necrosis ulcers) in...
There is now growing evidence that connective tissue diseases, including systemic sclerosis (SSc), share a common genetic background. Microarray studies support pivotal role of type I interferon (IFN) in the pathophysiology diseases. Interferon regulatory factors coordinate expression IFNs, and IRF5 gene has been identified as susceptibility lupus Sjögren's syndrome. The aim this study was to determine whether rs2004640 single-nucleotide polymorphism associated with SSc.The (GT) functional...
To investigate a new therapeutic strategy, with rapid corticosteroid dose tapering and limited cyclophosphamide (CYC) exposure, for older patients systemic necrotizing vasculitides (SNVs; polyarteritis nodosa [PAN], granulomatosis polyangiitis [Wegnener's] [GPA], microscopic [MPA], or eosinophilic GPA [Churg-Strauss] [EGPA]).A multicenter, open-label, randomized controlled trial comprising ≥65 years old newly diagnosed as having SNV was conducted. The experimental treatment consisted of...
Objectives. This longitudinal study investigated survival, risk factors and causes of death in the multicentre ItinérAIR-Sclérodermie cohort patients with SSc without severe pulmonary fibrosis or left heart disease at baseline. Methods. At 3-year follow-up, vital status was obtained from investigators French national records. Causes were classified as SSc-related otherwise. Data censored 37 months, time loss to whichever earlier. Survival estimated using Kaplan–Meier method. Multivariate...
There is increasing concern about heart and pulmonary vascular involvement in systemic sclerosis (SSc). One of the most severe complications SSc arterial hypertension (PAH). has been an increased awareness left ventricular (LV) diastolic abnormalities patients. However, previous studies have generally conducted small populations. The aims this study were to prospectively screen for PAH describe echocardiographic parameters a large group patients.This prospective was 21 centres France....
Abstract Objective Systemic sclerosis (SSc) belongs to the group of connective tissue disorders (CTDs), among which are several characterized by a type I interferon (IFN) signature. The recent identification an association between IRF5 and SSc further highlights key role for IFN. STAT4 , encodes STAT‐4, contributes IFN signaling, its genetic variants were found be associated with CTDs. aim this study was determine whether rs7574865 single‐nucleotide polymorphism is SSc, it interacts ....
To assess the effect of sildenafil, a phosphodiesterase type 5 inhibitor, on digital ulcer (DU) healing in systemic sclerosis (SSc).Randomised, placebo-controlled study patients with SSc to sildenafil 20 mg or placebo, three times daily for 12 weeks, ischaemic DU healing. The primary end point was time each DU. Time compared between groups using Cox models clustered data (two-sided tests, p=0.05).Intention-to-treat analysis involved 83 total 192 DUs (89 group and 103 placebo group). HR 1.33...
In most patients with nonsevere systemic necrotizing vasculitides (SNVs), remission is achieved glucocorticoids alone, but one-third experience a relapse within 2 years. This study was undertaken to determine whether the addition of azathioprine (AZA) could achieve higher sustained rate newly diagnosed eosinophilic granulomatosis polyangiitis (Churg-Strauss) (EGPA), microscopic (MPA), or polyarteritis nodosa (PAN).All included in this double-blind trial received glucocorticoids, gradually...
Background TNFAIP3 encodes the ubiquitin-modifying enzyme, a key regulator of inflammatory signalling pathways. Convincing associations between variants and autoimmune diseases have been reported. Objective To investigate association polymorphisms with systemic sclerosis (SSc). Methods Three single nucleotide (SNPs) in set 1018 patients SSc 1012 controls French Caucasian origin were genotyped. Two intergenic SNPs, rs10499194 rs6920220, one located intron 2, rs5029939, selected. The rs5029939...
<h3>Objectives</h3> The rarity of early diffuse cutaneous systemic sclerosis (dcSSc) makes randomised controlled trials very difficult. We aimed to use an observational approach compare effectiveness currently used treatment approaches. <h3>Methods</h3> This was a prospective, cohort study dcSSc (within three years onset skin thickening). Clinicians selected one four protocols for each patient: methotrexate, mycophenolate mofetil (MMF), cyclophosphamide or 'no immunosuppressant'. Patients...
Abstract Systemic sclerosis (SSc) is a generalized disease of the connective tissue, arterioles, and microvessels, characterized by appearance fibrosis vascular obliteration. There are two main phenotypical forms SSc: diffuse cutaneous form that extends towards proximal region limbs and/or torso, limited where only affects extremities (without passing beyond elbows knees). also exists in less than 10% cases never involve skin. This called SSc sine scleroderma. The prognosis depends...
Abstract Objective To determine whether the functional BANK1 variants rs3733197 and rs10516487 are associated with systemic sclerosis (SSc) in 2 European Caucasian populations to investigate putative gene–gene interactions between IRF5 as well STAT4 . Methods single‐nucleotide polymorphisms were genotyped a total population of 2,432 individuals. The French cohort consisted 874 SSc patients 955 controls (previously for both rs2004640 rs7574865). German 421 182 controls. Results found be...
Journal Article Imatinib mesylate in scleroderma‐associated diffuse skin fibrosis: a phase II multicentre randomized double‐blinded controlled trial Get access S. Prey, Prey Department of Dermatology, Hôpital Saint André, CHU de Bordeaux, 1 rue Jean Burguet, 33075 FranceUniversity 146, Léo Saignat 33000 FranceINSERM U1035, France Sorilla Prey. E‐mail: sorilla.prey@chu‐bordeaux.fr Search for other works by this author on: Oxford Academic Google Scholar K. Ezzedine, Ezzedine A. Doussau,...
Objective. Digital ulcers are the most frequent vascular manifestations of systemic sclerosis (SSc). Clinical features patients with prior or current digital have not been extensively described. This cross-sectional analysis a large multicenter cohort compared characteristics SSc those never affected. Methods. Patients prior/current affected were identified in enrolled French ItinérAIR-Sclérodermie registry. Rodnan skin scores, pulmonary function test results, and clinical immunological data...