A5089880659- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal Diseases and Glomerulopathies
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Complement system in diseases
- Pharmacological Effects and Toxicity Studies
- Renal and Vascular Pathologies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatological and Skeletal Disorders
- Vasculitis and related conditions
- Parathyroid Disorders and Treatments
- Autoimmune Bullous Skin Diseases
- Drug Transport and Resistance Mechanisms
- Renal Transplantation Outcomes and Treatments
- Platelet Disorders and Treatments
- Dialysis and Renal Disease Management
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Pancreatitis Pathology and Treatment
- Neurological Complications and Syndromes
- Protein Kinase Regulation and GTPase Signaling
- Systemic Lupus Erythematosus Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neurological and metabolic disorders
- IgG4-Related and Inflammatory Diseases
Université de Poitiers
2016-2025
Contrôle de la Réponse Immune B et Lymphoproliférations
2010-2024
Université de Limoges
2015-2024
Centre Hospitalier Universitaire de Poitiers
2015-2024
Inserm
2014-2024
Centre National de la Recherche Scientifique
2015-2024
Centre Hospitalier Universitaire de Limoges
1999-2024
Laboratoire National de Référence
2024
Amyloidosis Foundation
2017-2022
Centre de Référence des Maladies Autoinflammatoires et des Amyloses
2018-2021
The Kidney Disease: Improving Global Outcomes (KDIGO) 2021 Clinical Practice Guideline for the Management of Glomerular Diseases is an update to KDIGO 2012 guideline on topic. aim assist clinicians caring individuals with glomerular disease, both adults and children. scope includes various diseases, including IgA nephropathy (IgAN) vasculitis (IgAV), membranous nephropathy, nephrotic syndrome in children, minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS),...
The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Management of Glomerular Diseases is an update to KDIGO 2012 guideline. aim assist clinicians caring individuals with glomerulonephritis (GN), both adults and children. scope includes various glomerular diseases, including IgA nephropathy vasculitis, membranous nephropathy, nephrotic syndrome, minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), infection-related GN, antineutrophil...
High-dose chemotherapy followed by autologous hematopoietic stem-cell transplantation has been reported to provide higher response rates and better overall survival than standard in immunoglobulin-light-chain (AL) amyloidosis, but these two strategies have not compared a randomized study.
In contrast to pregnancy-associated thrombotic thrombocytopenic purpura, the pathogenesis and presentation of atypical hemolytic uremic syndrome (P-aHUS) remain ill-defined. We conducted a retrospective study assess outcomes patients presenting with P-aHUS prevalence alternative C3 convertase dysregulation. occurred in 21 100 adult female HUS, 79% postpartum. detected complement abnormalities 18 patients. The were poor: 62% reached ESRD by 1 month 76% last follow-up. risk for was highest...
Acute graft rejection remains a major problem in renal transplant recipients, and there is no consensus on the optimal immunosuppressive strategy. Immunoprophylaxis with Thymoglobulin® or basiliximab has significantly reduced incidence of acute episodes loss following kidney transplantation. This open, randomized, multicenter study investigated efficacy tolerability (20 mg day 0– 4) plus early cyclosporine from 0 (n = 50) compared delayed adult patients. In addition, all patients received...
Gitelman's syndrome (GS) is a rare, autosomal recessive, salt-losing tubulopathy caused by mutations in the SLC12A3 gene, which encodes thiazide-sensitive NaCl cotransporter (NCC). Because 18 to 40% of suspected GS patients carry only one mutant allele, large genomic rearrangements may account for unidentified mutations. Here, we directly sequenced DNA from cohort 448 unrelated having GS. We found 172 distinct mutations, 100 were unreported previously. In 315 (70%), identified two mutations;...
We describe a kindred with slowly progressive gastrointestinal symptoms and autonomic neuropathy caused by autosomal dominant, hereditary systemic amyloidosis. The amyloid consists of Asp76Asn variant β(2)-microglobulin. Unlike patients dialysis-related amyloidosis sustained high plasma concentrations wild-type β(2)-microglobulin, the affected members this had normal renal function circulating β(2)-microglobulin values. was thermodynamically unstable remarkably fibrillogenic in vitro under...
<h3>Importance</h3> Cast nephropathy is the main cause of acute kidney injury in multiple myeloma and persistent reduction function strongly affects prognosis. Strategies to rapidly remove nephrotoxic serum-free light chains combined with novel antimyeloma agents have not been evaluated prospectively. <h3>Objective</h3> To compare hemodialysis independence rate among patients newly diagnosed cast treated using a high-cutoff dialyzer (with very large membrane pores high permeability...
Fibrillary glomerulonephritis (FGN) is a rare disease with unknown pathogenesis and poor prognosis. Until now, the diagnosis of this has required demonstration glomerular deposition randomly oriented fibrils by electron microscopy that are Congo red negative stain antisera to Igs. We recently discovered novel proteomic tissue biomarker for FGN, namely, DNAJB9.In work, we developed DNAJB9 immunohistochemistry tested its sensitivity specificity FGN. This testing was performed on renal biopsy...