A5062054752- Renal Transplantation Outcomes and Treatments
- Vasculitis and related conditions
- SARS-CoV-2 and COVID-19 Research
- Organ Transplantation Techniques and Outcomes
- COVID-19 Clinical Research Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Hematopoietic Stem Cell Transplantation
- Complement system in diseases
- Renal and Vascular Pathologies
- Otitis Media and Relapsing Polychondritis
- Transplantation: Methods and Outcomes
- Polyomavirus and related diseases
- Dialysis and Renal Disease Management
- Cytomegalovirus and herpesvirus research
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- Neurological Complications and Syndromes
- Liver Disease and Transplantation
- T-cell and B-cell Immunology
- Urticaria and Related Conditions
- Acute Myeloid Leukemia Research
- COVID-19 Impact on Reproduction
- Heparin-Induced Thrombocytopenia and Thrombosis
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
Tufts Medical Center
2024
Erasmus MC
2024
Charles University
2024
The Ohio State University
2024
Tufts University
2024
Brown University
2024
University of Calgary
2024
RWTH Aachen University
2024
The Kidney Disease: Improving Global Outcomes (KDIGO) 2021 Clinical Practice Guideline for the Management of Glomerular Diseases is an update to KDIGO 2012 guideline on topic. aim assist clinicians caring individuals with glomerular disease, both adults and children. scope includes various diseases, including IgA nephropathy (IgAN) vasculitis (IgAV), membranous nephropathy, nephrotic syndrome in children, minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS),...
Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause unknown, there debate about whether it single disease entity what role ANCA plays in its pathogenesis. We investigated genetic basis.
To analyze factors that affect the collection of peripheral-blood stem cells (PBSC) before transplant and tempo engraftment after transplant.A consecutive series 243 patients with breast cancer (n = 87), malignant lymphoma 90), multiple myeloma 32), or other malignancies 34) had PBSC collected following stimulation colony-stimulating (CSFs) chemotherapy followed by CSF. Infusion was performed myeloablative without total-body irradiation (TBI). Postinfusion CSFs were administered to 72...
The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Management of Glomerular Diseases is an update to KDIGO 2012 guideline. aim assist clinicians caring individuals with glomerulonephritis (GN), both adults and children. scope includes various glomerular diseases, including IgA nephropathy vasculitis, membranous nephropathy, nephrotic syndrome, minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), infection-related GN, antineutrophil...
In kidney patients COVID-19 is associated with severely increased morbidity and mortality. A comprehensive comparison of the immunogenicity, tolerability, safety vaccination in different cohorts a control cohort lacking.This investigator driven, prospective, controlled multicenter study included 162 participants chronic disease (CKD) stages G4/5 (eGFR < 30 mL/min/1.73m2), 159 on dialysis, 288 transplant recipients, 191 controls. Participants received 2 doses mRNA-1273 vaccine (Moderna). The...
This article is published as part of a supplement sponsored by Kidney Disease: Improving Global Outcomes (KDIGO). The opinions or views expressed in this are those the authors and do not necessarily reflect recommendations International Society Nephrology Elsevier. Dosages, indications, methods use for products that referred to may their clinical experience be derived from professional literature other sources.
PURPOSE This study was designed to determine the toxicity, radiographic response rate, and outcome following high-dose thiotepa, etoposide, autologous bone marrow rescue (ABMR) for young patients with recurrent malignant brain tumors. METHODS Eligibility criteria required adequate renal, hepatic, pulmonary function, no infiltration. Thiotepa 300 mg/m2 etoposide 500 mg/ m2 were infused on 3 consecutive days, 72 hours chemotherapy. RESULTS Forty-five high-grade tumors, aged 8 months 36 years...
Objective. We performed a retrospective evaluation of whether c-ANCA titres (indirect immunofluorescence) and anti-proteinase 3 (PR3)-ANCA levels (ELISA) at diagnosis following immunosuppressive treatment are predictive relapse ANCA-associated vasculitis.
This study evaluated predictors for patient and renal survival in patients with ANCA-associated vasculitis (AAV) without involvement.There were 273 consecutive AAV from January 1990 until December 2007 who followed death, loss to follow-up, or 2010. Based on organ involvement, divided into (n=212) nonrenal groups (n=61). The primary end point was ESRD requiring replacement therapy (RRT) transplantation death.Patient significantly better the group compared (hazard ratio, 0.55; 95% confidence...
Cyclosporine, everolimus, and tacrolimus are the cornerstone of immunosuppressive therapy in renal transplantation. These drugs characterized by narrow therapeutic windows, highly variable pharmacokinetics (PK), metabolism CYP3A enzymes. Recently, decreased activity allele, CYP3A4*22, was described as a potential predictive marker for CYP3A4 activity. This study investigated effect CYP3A5*3, combined genotypes on cyclosporine, PK transplant patients. CYP3A4*22 carriers showed significant...
A specific biomarker that can separate active renal vasculitis from other causes of dysfunction is lacking, with a kidney biopsy often being required. Soluble CD163 (sCD163), shed by monocytes and macrophages, has been reported as potential in diseases associated excessive macrophage activation. Thus, we hypothesized urinary sCD163 crescent macrophages correlates glomerular inflammation. We detected rat urine early the disease course experimental vasculitis. Moreover, microdissected...
Organ transplantation is a life-saving treatment for patients with end-stage disease, but survival rates after vary considerably. There now increasing evidence that the gut microbiome linked to of undergoing hematopoietic cell transplant, yet little known about role in solid organ transplantation. We analyzed 1370 fecal samples from 415 liver and 672 renal transplant recipients using shotgun metagenomic sequencing assess microbial taxonomy, metabolic pathways, antibiotic resistance genes,...
In 2021, the Kidney Disease: Improving Global Outcomes (KDIGO) Guideline for Management of Glomerular Diseases was published. KDIGO is committed to providing nephrology community with periodic updates, based on new developments each disease. For patients anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), avacopan received regulatory approval in late leading this guideline update. addition, evidence supporting a lower-dose glucocorticoid induction regimen or even...
PURPOSE The purpose of this report was to review the Seattle experience in bone marrow transplantation (BMT) for acute myeloid leukemia (AML) during untreated first relapse. PATIENTS AND METHODS Through 1990, 126 patients were transplanted relapse AML. Several preparative regimens used, two which involved more than 20 patients. Regimen 1 (29 patients) consisted cyclophosphamide (CY) 120 mg/kg and 15.75 Gy fractionated total-body irradiation (TBI) with methotrexate (MTX) given intermittently...
In a 24-month, multicenter, open-label, randomized trial, 715 de novo kidney transplant recipients were at 10-14 weeks to convert everolimus (n = 359) or remain on standard calcineurin inhibitor (CNI) therapy 356; 231 tacrolimus; 125 cyclosporine), all with mycophenolic acid and steroids. The primary endpoint, change in estimated glomerular filtration rate (eGFR) from randomization month 12, was similar for versus CNI: mean (standard error) 0.3(1.5) mL/min/1.732 -1.5(1.5) (p 0.116)....
Individual HLA mismatches may differentially impact graft survival after kidney transplantation. Therefore, there is a need for reliable tool to define permissible in We previously demonstrated that donor-derived Predicted Indirectly ReCognizable Epitopes presented by recipient class II (PIRCHE-II) play role de novo DSA formation In the present Dutch multi-center study we evaluated possible association between PIRCHE-II and failure 2,918 donor-recipient couples were transplanted 1995 2005....
High-density lipoprotein (HDL) particles are involved in the protection against cardiovascular disease by promoting cholesterol efflux, which accumulated is removed from macrophage foam cells. We investigated whether HDL efflux capacity associated with mortality, all-cause and graft failure a cohort of renal transplant recipients (n=495, median follow-up 7.0 years). Cholesterol at baseline was quantified using incubation human cells apolipoprotein B-depleted plasma. Baseline not different...